ChemicalBook > CAS DataBase List > CCG-203971
CCG-203971
- Product Name
- CCG-203971
- CAS No.
- 1443437-74-8
- Chemical Name
- CCG-203971
- Synonyms
- 3-Piperidinecarboxamide, N-(4-chlorophenyl)-1-[3-(2-furanyl)benzoyl]-;203971;CC 203971;CCG-203971;CCG 203971;CCG203971;CCG-203971;N-(4-Chlorophenyl)-1-[3-(2-furanyl)benzoyl]-3-piperidinecarboxamide;N-(4-chlorophenyl)-1-[3-(furan-2-yl)benzoyl]piperidine-3-carboxamide;Rho,Ras,Inhibitor,SRF,CCG 203971,CCG-203971,MKL1,inhibit,MRTF,anti-metastasis,PC-3,migration
- CBNumber
- CB13067539
- Molecular Formula
- C23H21ClN2O3
- Formula Weight
- 408.88
- MOL File
- 1443437-74-8.mol
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CCG-203971 Property
- Boiling point:
- 656.0±55.0 °C(Predicted)
- Density
- 1.305±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:81.0(Max Conc. mg/mL);198.1(Max Conc. mM)
- form
- powder
- pka
- 13.69±0.70(Predicted)
- color
- white to beige
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML1422
- Product name
- CCG-203971
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $70.8
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML1422
- Product name
- CCG-203971
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $289
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 5.30985
- Product name
- MICAL-2 Inhibitor II, CCG-203971 - CAS 1443437-74-8 - Calbiochem
- Packaging
- 10mg
- Price
- $185
- Updated
- 2023/01/07
Cayman Chemical
- Product number
- 15075
- Product name
- CCG-203971
- Purity
- ≥90%
- Packaging
- 5mg
- Price
- $48
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 15075
- Product name
- CCG-203971
- Purity
- ≥90%
- Packaging
- 10mg
- Price
- $89
- Updated
- 2024/03/01
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CCG-203971 Chemical Properties,Usage,Production
Uses
CCG 203971 acts as an antifibrotic agent, inhibiting fibrosis through targeting the MRTF/SRF gene transcription pathway. Inhibits the invasion of prostate cancer cells and acts as a potent anti-proliferative agent.
Biochem/physiol Actions
CCG-203971 is an inhibitor of the Rho/MKL1/SRF transcriptional pathway, which has been shown to play a role in metastasis of melanoma and breast cancer and clinically associated with castration-resistant prostate cancer. CCG-203971 is a second-generation analog of CCG-1423 (SML0987) with an IC50 of 4.2 μM vs 1 μM for CCG-1423, but less cytotoxicity. In mouse studies, CCG-203971 inhibited invasion of PC-3 prostate cancer cells and was well tolerated up to doses of 100 mg/kg IP over 5 days. The Rho/MRTF/SRF pathway has also been shown to be involved in multiple types of solid organ fibrosis. CCG-203971 repressed both matrix-stiffness and TGF-β-mediated fibrogenesis in human colonic myofibroblasts and showed antifibrotic activity in a murine model of skin injury and in pulmonary fibrosis lung fibroblasts.
CCG-203971 Preparation Products And Raw materials
Raw materials
Preparation Products
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