FAUC-365

Product Name: FAUC-365
CAS No.: 474432-66-1
Chemical Name: FAUC-365
Synonyms: FAUC-365;3-dichloro-;FAUC-365, 10 mM in DMSO;FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2;N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)benzo[b]thiophene-2-carboxamide;Benzo[b]thiophene-2-carboxamide, N-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyl]-;Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide;FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide;inhibit,Parkinson's disease,Dopamine Receptor,D3 receptor,FAUC365,Dopamine,Inhibitor,FAUC-365,schizophrenia,SPET,Radioligand,FAUC 365
CBNumber: CB13067544
Molecular Formula: C23H25Cl2N3OS
Formula Weight: 462.4351
MOL File: 474432-66-1.mol

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FAUC-365 Property

Boiling point:: 680.3±55.0 °C(Predicted)
Density: 1.300±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥5.79 mg/mL in DMSO
form: A crystalline solid
pka: 14.55±0.46(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20457
Product name: FAUC-365
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 20457
Product name: FAUC-365
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 20457
Product name: FAUC-365
Packaging: 10mg
Price: $274
Updated: 2024/03/01

ApexBio Technology

Product number: C4494
Product name: FAUC-365
Packaging: 10mg
Price: $243
Updated: 2021/12/16

AK Scientific

Product number: 6525CR
Product name: N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]-1-benzothiophene-2-carboxamide
Packaging: 1mg
Price: $147
Updated: 2021/12/16

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FAUC-365 Chemical Properties,Usage,Production

Description

FAUC-365 is a dopamine D₃ receptor antagonist (K_i = 0.5 nM). It is selective for dopamine D₃ receptors over dopamine D₁, D_2L, D_2S, and D₄ receptors (K_is = 8.8, 3.6, 2.6, and 0.34 μM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT_1A and 5-HT₂ (K_is = 0.36 and 2 μM, respectively). FAUC-365 (1-10 mg/kg) prevents memory impairment in the novel object recognition test in dopamine transporter knockdown (DAT-KD) mice when administered prior to object learning.

Uses

FAUC 365 is a highly dopamine D3 receptor-selective antagonist with Ki values of 0.5 nM, 340, 2600, and 3600 nM at D3, D4.4, D2short, and D2Long receptors, respectively. FAUC 365 can be used for the research of schizophrenia, and Parkinson's disease[1][2].

in vitro

fauc-365 was discovered by a rational and interactive sar sequence. as a dichloro derivative, fauc-365 revealed d3 affinities that were comparable to its methoxy-substituted analogues, however, the selectivities of fauc-365 against 5ht-1a, 5-ht2, and r1 were substantially higher, which was demonstrated by that extraordinary selectivity ratios of 17600, 7200, 5200, and 680 over d1, d2long, d2short, and d4, respectively, were determined for fauc-365 with ki of 0.50 nm. in addition, the benzothiophene analog fauc 346 and its oxa analogue showed partial agonist character with ec50 values at 0.36 and 1.5 nm, respectively [1].

References

[1] bettinetti l, schlotter k, hübner h, gmeiner p. interactive sar studies: rational discovery of super-potent and highly selective dopamine d3 receptor antagonists and partial agonists. j med chem. 2002 oct 10;45(21):4594-7.

FAUC-365 Preparation Products And Raw materials

Raw materials

Preparation Products

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FAUC-365 Suppliers

China 32 United Kingdom 1 United States 5 Global 38

BOC Sciences

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Pharmacodia (Beijing) Co.,Ltd

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474432-66-1, FAUC-365Related Search:

FAUC-365

FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide

3-dichloro-

FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2

inhibit,Parkinson's disease,Dopamine Receptor,D3 receptor,FAUC365,Dopamine,Inhibitor,FAUC-365,schizophrenia,SPET,Radioligand,FAUC 365

Benzo[b]thiophene-2-carboxamide, N-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyl]-

FAUC-365, 10 mM in DMSO

Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide

N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)benzo[b]thiophene-2-carboxamide

474432-66-1

C23H25CI2N3OS