FAUC-365

Product Name: FAUC-365
CAS No.: 474432-66-1
Chemical Name: FAUC-365
Synonyms: FAUC-365;3-dichloro-;FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2;Benzo[b]thiophene-2-carboxamide, N-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyl]-;FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide;inhibit,Parkinson's disease,Dopamine Receptor,D3 receptor,FAUC365,Dopamine,Inhibitor,FAUC-365,schizophrenia,SPET,Radioligand,FAUC 365
CBNumber: CB13067544
Molecular Formula: C23H25Cl2N3OS
Formula Weight: 462.4351
MOL File: 474432-66-1.mol

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FAUC-365 Property

Boiling point:: 680.3±55.0 °C(Predicted)
Density: 1.300±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥5.79 mg/mL in DMSO
form: A crystalline solid
pka: 14.55±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20457
Product name: FAUC-365
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 20457
Product name: FAUC-365
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 20457
Product name: FAUC-365
Packaging: 10mg
Price: $274
Updated: 2024/03/01

ApexBio Technology

Product number: C4494
Product name: FAUC-365
Packaging: 10mg
Price: $243
Updated: 2021/12/16

AK Scientific

Product number: 6525CR
Product name: N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]-1-benzothiophene-2-carboxamide
Packaging: 1mg
Price: $147
Updated: 2021/12/16

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FAUC-365 Chemical Properties,Usage,Production

Description

FAUC-365 is a dopamine D₃ receptor antagonist (K_i = 0.5 nM). It is selective for dopamine D₃ receptors over dopamine D₁, D_2L, D_2S, and D₄ receptors (K_is = 8.8, 3.6, 2.6, and 0.34 μM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT_1A and 5-HT₂ (K_is = 0.36 and 2 μM, respectively). FAUC-365 (1-10 mg/kg) prevents memory impairment in the novel object recognition test in dopamine transporter knockdown (DAT-KD) mice when administered prior to object learning.

in vitro

fauc-365 was discovered by a rational and interactive sar sequence. as a dichloro derivative, fauc-365 revealed d3 affinities that were comparable to its methoxy-substituted analogues, however, the selectivities of fauc-365 against 5ht-1a, 5-ht2, and r1 were substantially higher, which was demonstrated by that extraordinary selectivity ratios of 17600, 7200, 5200, and 680 over d1, d2long, d2short, and d4, respectively, were determined for fauc-365 with ki of 0.50 nm. in addition, the benzothiophene analog fauc 346 and its oxa analogue showed partial agonist character with ec50 values at 0.36 and 1.5 nm, respectively [1].

References

[1] bettinetti l, schlotter k, hübner h, gmeiner p. interactive sar studies: rational discovery of super-potent and highly selective dopamine d3 receptor antagonists and partial agonists. j med chem. 2002 oct 10;45(21):4594-7.

FAUC-365 Preparation Products And Raw materials

Raw materials

Preparation Products

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FAUC-365 Suppliers

China 23 United Kingdom 1 United States 5 Global 29

BOC Sciences

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Pharmacodia (Beijing) Co.,Ltd

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ShangHai Biochempartner Co.,Ltd

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Lynnchem

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Novachemistry

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TargetMol Chemicals Inc.

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474432-66-1, FAUC-365Related Search:

FAUC-365

FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide

3-dichloro-

FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2

inhibit,Parkinson's disease,Dopamine Receptor,D3 receptor,FAUC365,Dopamine,Inhibitor,FAUC-365,schizophrenia,SPET,Radioligand,FAUC 365

Benzo[b]thiophene-2-carboxamide, N-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyl]-

474432-66-1

C23H25CI2N3OS