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LT175

Product Name
LT175
CAS No.
862901-87-9
Chemical Name
LT175
Synonyms
LT175;TZTPJJNNACUQQR-FQEVSTJZSA-N;Benzenepropanoic acid, a-([1,1'-biphenyl]-4-yloxy)-, (aS)-;Benzenepropanoic acid, α-([1,1'-biphenyl]-4-yloxy)-, (αS)-
CBNumber
CB13067559
Molecular Formula
C21H18O3
Formula Weight
318.37
MOL File
862901-87-9.mol
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LT175 Property

storage temp. 
Store at -20°C
solubility 
≤25mg/ml in ethanol;50mg/ml in DMSO;30mg/ml in dimethyl formamide
form 
crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
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N-Bromosuccinimide Price

Cayman Chemical
Product number
17636
Product name
LT175
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17636
Product name
LT175
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
17636
Product name
LT175
Purity
≥98%
Packaging
10mg
Price
$169
Updated
2024/03/01
Cayman Chemical
Product number
17636
Product name
LT175
Purity
≥98%
Packaging
25mg
Price
$381
Updated
2024/03/01
Usbiological
Product number
453935
Product name
LT 175
Packaging
1mg
Price
$319
Updated
2021/12/16
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LT175 Chemical Properties,Usage,Production

Uses

LT 175 is used as an dual PPARα/γ ligand which shows partial agonism to PPARγ. It exhibits low adipogenic activity in vitro and improves glucose homeostasis in diet-induced insulin resistant mice.

Biological Activity

lt175 is a dual pparα/γ ligand.peroxisome proliferator-activated receptors (ppars) are ligand-dependent transcription factors regulating lipid and glucose metabolism.

in vitro

lt175 was identified as a partial agonist against pparγ and interacted with a newly identified region of the pparγ-ligand binding domain. lt175 could differentially activate pparγ target genes involved in fatty acid esterification and storage, resulting in a less severe lipid accumulation compared with that triggered by rosiglitazone. moreover, the peculiar interaction of lt175 with pparγ could affect the recruitment of the coregulators cyclic-amp response element-binding protein-binding protein and nuclear corepressor 1 [1].

in vivo

animal in vivo study showed that the administration of lt175 to mice fed a high-fat diet could decrease the adipocyte size, body weight, as well as white adipose tissue mass, as measured by magnetic resonance imaging. in addition, lt175 was able to significantly reduce the insulin, plasma glucose, triglycerides, non-esterified fatty acids, and cholesterol and also could increase the levels of circulating adiponectin and fibroblast growth factor 21. moreover, the oral glucose and insulin tolerance tests showed that lt175 could improve glucose homeostasis and insulin sensitivity [1].

IC 50

hPPARα: 0.22 μM (EC50); mPPARα: 0.26 μM (EC50); hPPARγ: 0.48 μM (EC50)

References

[1] gilardi f et al. lt175 is a novel pparα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. j biol chem. 2014 mar 7;289(10):6908-20.

LT175 Preparation Products And Raw materials

Raw materials

Preparation Products

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LT175 Suppliers

CHINA 26 United Kingdom 1 United States 5 Global 32
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Tanmo Quality Inspection Technology Co., Ltd.
Tel
4008-099-669
Email
23419001name@qq.com
Country
CHINA
ProdList
6043
Advantage
58

862901-87-9, LT175Related Search:


  • LT175
  • TZTPJJNNACUQQR-FQEVSTJZSA-N
  • Benzenepropanoic acid, α-([1,1'-biphenyl]-4-yloxy)-, (αS)-
  • Benzenepropanoic acid, a-([1,1'-biphenyl]-4-yloxy)-, (aS)-
  • 862901-87-9