Mycro3

Product Name: Mycro3
CAS No.: 944547-46-0
Chemical Name: Mycro3
Synonyms: Mycro3;Mycro-3, >98%;Mycro 3 ，S0249;Mycro 3, 10 mM in DMSO;dimerization,Mycro 3,pancreatic,inhibit,adenocarcinoma,ductal,c-Myc,Inhibitor,PDA,Autophagy,Mycro3,MAX,Myc;ethyl 5-[7-(chlorodifluoromethyl)-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-amido]-1-phenyl-1H-pyrazole-4-carboxylate;Ethyl 5-(7-(chlorodifluoromethyl)-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-carboxamido)-1-phenyl-1H-pyrazole-4-carboxylate;ethyl 5-[[7-[chloro(difluoro)methyl]-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]-1-phenylpyrazole-4-carboxylate;1H-Pyrazole-4-carboxylic acid, 5-[[[7-(chlorodifluoromethyl)-5-(2-furanyl)pyrazolo[1,5-a]pyrimidin-2-yl]carbonyl]amino]-1-phenyl-, ethyl ester
CBNumber: CB13067564
Molecular Formula: C24H17ClF2N6O4
Formula Weight: 526.88
MOL File: 944547-46-0.mol

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Mycro3 Property

Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO : ≥ 100 mg/mL (189.80 mM)
pka: 6.95±0.46(Predicted)
form: Solid
color: Light yellow to yellow
InChIKey: YPPNLSKYXDXQGD-UHFFFAOYSA-N
SMILES: N1(C2=CC=CC=C2)C(NC(C2C=C3N(N=2)C(C(Cl)(F)F)=CC(C2=CC=CO2)=N3)=O)=C(C(OCC)=O)C=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: SYN5206
Product name: Mycro3
Packaging: 10mg
Price: $340
Updated: 2021/12/16

Ambeed

Product number: A708851
Product name: Mycro-3
Purity: 98%
Packaging: 5mg
Price: $116
Updated: 2021/12/16

Ambeed

Product number: A708851
Product name: Mycro-3
Purity: 98%
Packaging: 10mg
Price: $151
Updated: 2021/12/16

Ambeed

Product number: A708851
Product name: Mycro-3
Purity: 98%
Packaging: 25mg
Price: $197
Updated: 2021/12/16

Ambeed

Product number: A708851
Product name: Mycro-3
Purity: 98%
Packaging: 50mg
Price: $257
Updated: 2021/12/16

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Mycro3 Chemical Properties,Usage,Production

Uses

Mycro 3 is an orally active, potent and selective inhibitor of Myc-associated factor X (MAX) dimerization. Mycro 3 also inhibit DNA binding of c-Myc[1]. Mycro 3 could be used for the research of pancreatic cancer[2].

Biological Activity

Mycro 3 is a potent selective Myc-Max dimerization inhibitor. It can be used in pancreatic cancer research.

in vitro

Mycro 3 is a potent and selective c-Myc inhibitor in whole cell assays, with weak inhibitory activity against Activator protein 1 (AP-1). It has a superior specificity profile to its predecessors. It inhibits the interaction between c-Myc and Max. It has high selectivity and inhibits c-Myc/Max dimerization and conjugation with DNA.

in vivo

Mycro 3 (100 mg/kg; oral administration; daily for two months) induces marked shrinkage of pancreatic ductal adenocarcinoma (PDA), increases cancer cell apoptosis, and reduces cell proliferation. Tumor growth is also drastically attenuated in Mycro 3-treated NOD/SCID mice carrying orthotopic or heterotopic xenografts of human pancreatic cancer cells^[2].

Animal Model:	Moribund Pdx1-cre/KRAS* mice bearing pancreatic ductal adenocarcinoma (PDA)^[2]
Dosage:	100 mg/kg
Administration:	Oral administration; daily for two months
Result:	Increased survival time. Mycro 3 administration was discontinued after two months, the mouse survived for an additional month.

target

Myc-MAX dimerization

References

[1] Chen BJ, et al. Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics. Int J Biol Sci. 2014 Sep 13;10(10):1084-96. DOI:10.7150/ijbs.10190
[2] Dimitris Stellas, et al. Therapeutic effects of an anti-Myc drug on mouse pancreatic cancer. J Natl Cancer Inst. 2014 Oct 11;106(12):dju320. DOI:10.1093/jnci/dju320

Mycro3 Preparation Products And Raw materials

Raw materials

Preparation Products

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Mycro3 Suppliers

China 77 United Kingdom 1 United States 7 USA 1 Global 86

Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

Tel: 024-024-024-88590548 18341751992
Email: 757984502@qq.com
Country: China
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MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4817
Advantage: 55

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
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Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
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Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
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944547-46-0, Mycro3Related Search:

Mycro3

ethyl 5-[[7-[chloro(difluoro)methyl]-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]-1-phenylpyrazole-4-carboxylate

Mycro-3, >98%

1H-Pyrazole-4-carboxylic acid, 5-[[[7-(chlorodifluoromethyl)-5-(2-furanyl)pyrazolo[1,5-a]pyrimidin-2-yl]carbonyl]amino]-1-phenyl-, ethyl ester

Ethyl 5-(7-(chlorodifluoromethyl)-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-carboxamido)-1-phenyl-1H-pyrazole-4-carboxylate

dimerization,Mycro 3,pancreatic,inhibit,adenocarcinoma,ductal,c-Myc,Inhibitor,PDA,Autophagy,Mycro3,MAX,Myc

ethyl 5-[7-(chlorodifluoromethyl)-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-amido]-1-phenyl-1H-pyrazole-4-carboxylate

Mycro 3, 10 mM in DMSO

Mycro 3 ，S0249

944547-46-0

C24H17ClF2N6O4