thiophene-2,4-dicarbaldehyde
- Product Name
- thiophene-2,4-dicarbaldehyde
- CAS No.
- 932-93-4
- Chemical Name
- thiophene-2,4-dicarbaldehyde
- Synonyms
- thiophene-2,4-dicarbaldehyde;2,4-Thiophenedicarboxaldehyde
- CBNumber
- CB13076287
- Molecular Formula
- C6H4O2S
- Formula Weight
- 140.16
- MOL File
- 932-93-4.mol
thiophene-2,4-dicarbaldehyde Property
- Melting point:
- 81 °C
- Boiling point:
- 287.8±25.0 °C(Predicted)
- Density
- 1.370±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- T430308
- Product name
- Thiophene-2,4-dicarbaldehyde
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 7920CE
- Product name
- Thiophene-2,4-dicarbaldehyde
- Packaging
- 100mg
- Price
- $136
- Updated
- 2021/12/16
- Product number
- 7920CE
- Product name
- Thiophene-2,4-dicarbaldehyde
- Packaging
- 500mg
- Price
- $148
- Updated
- 2021/12/16
- Product number
- CHM0004239
- Product name
- THIOPHENE-2,4-DICARBOXALDEHYDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505
- Updated
- 2021/12/16
- Product number
- CD00000487
- Product name
- Thiophene-2,4-dicarbaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $525
- Updated
- 2021/12/16
thiophene-2,4-dicarbaldehyde Chemical Properties,Usage,Production
Synthesis
3140-92-9
68-12-2
932-93-4
General method: 2,4-dibromothiophene (0.5 g, 2.07 mmol) was dissolved in THF (20 ml) under argon protection and cooled to -78 °C. A n-butyllithium solution (2.5 M hexane solution, 0.91 ml, 2.28 mmol, 1.1 eq.) was slowly added dropwise, keeping the temperature at -78 °C. Subsequently, the reaction mixture was slowly warmed to 0 °C over 30 min. Anhydrous N,N-dimethylformamide (182 mg, 2.48 mmol, 1.2 eq.) was added and the reaction mixture was stirred at room temperature for 2 hours. Cooled again to -78 °C, tert-butyllithium solution (1.7 M pentane solution, 1.58 ml, 2.69 mmol, 1.3 eq.) was added and stirred for 5 min. An excess of anhydrous N,N-dimethylformamide (1 ml) was then added and the reaction mixture was stirred overnight at room temperature. After completion of the reaction, the solution was poured into 1N HCl (10 ml) and stirred for 20 min. After neutralization with aqueous NaHCO3, the aqueous phase was extracted with dichloromethane (3 x 30 ml). The organic phases were combined, dried with anhydrous MgSO4 and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=6:1) to afford thiophene-2,4-dicarboxaldehyde (123 mg, 42%) as a yellow amorphous solid.
References
[1] Tetrahedron Letters, 2013, vol. 54, # 22, p. 2795 - 2798
[2] Journal of the American Chemical Society, 1995, vol. 117, # 9, p. 2467 - 2478
thiophene-2,4-dicarbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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