MK 0657-CIS-(-)-ISOMER

Product Name: MK 0657-CIS-(-)-ISOMER
CAS No.: 808732-98-1
Chemical Name: MK 0657-CIS-(-)-ISOMER
Synonyms: MK-0657;CERC301;CERC-301;CERC 301;Rislenemdaz;Rislenemdaz/MK-0657;MK 0657-CIS-(-)-ISOMER;Rislenemdaz, 10 mM in DMSO;4-Methylbenzyl (3S,4R)-3-fluoro-4-((pyrimidin-2-ylamino)methyl)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 3-fluoro-4-[(2-pyrimidinylamino)methyl]-, (4-methylphenyl)methyl ester, (3S,4R)-
CBNumber: CB13110635
Molecular Formula: C19H23FN4O2
Formula Weight: 358.41
MOL File: 808732-98-1.mol

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MK 0657-CIS-(-)-ISOMER Property

Boiling point:: 527.4±60.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 150 mg/mL (418.52 mM)
form: Solid
pka: 3.75±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-7798
Product name: Rislenemdaz
Purity: 98.01%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-7798
Product name: Rislenemdaz
Purity: 98.01%
Packaging: 5mg
Price: $540
Updated: 2021/12/16

ChemScene

Product number: CS-7798
Product name: Rislenemdaz
Purity: 98.01%
Packaging: 10mg
Price: $900
Updated: 2021/12/16

ChemScene

Product number: CS-7798
Product name: Rislenemdaz
Purity: 98.01%
Packaging: 50mg
Price: $2700
Updated: 2021/12/16

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MK 0657-CIS-(-)-ISOMER Chemical Properties,Usage,Production

Uses

Rislenemdaz (CERC-301) is an orally bioavailable and selective N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM, respectively.

in vivo

Rislenemdaz (CERC-301) (1, 3, 10, and 30 mg/kg) significantly decreases immobility frequency (P<0.001) and significantly increases swimming behavior (P<0.01 for 1, 3, and 30 mg/kg; P<0.05 for 10 mg/kg) compare to the vehicle control. Rislenemdaz plasma levels are approximately 15, 120, 390, 1420, 4700, and 14,110 nM (0.015, 0.120, 0.390, 1.42, 4.7, and 14.11 uM) at the time of sampling, corresponding to approximately 5, 29, 56, 83, 94, and 98% RO, respectively, in rats. The ED₅₀ for increaing in frequency of swimming and decreasing in immobility are ~0.3 and 0.7 mg/kg, respectively, corresponding to RO of ~30 and 50%. Rislenemdaz (1, 3, 10, and 30 mg/kg) significantly increases total distance traveling (P<0.01 for 1 mg/kg; P<0.001 for 3, 10, and 30 mg/kg) compare to vehicle control over the 60 min test^[1].

References

[1] Rachel Garner, et al. Preclinical pharmacology and pharmacokinetics of CERC‐301, a GluN2B‐selective N‐methyl‐D‐aspartate receptor antagonist. Pharmacol Res Perspect. 2015 Dec; 3(6): e00198. DOI:10.1002/prp2.198

MK 0657-CIS-(-)-ISOMER Preparation Products And Raw materials

Raw materials

Preparation Products

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MK 0657-CIS-(-)-ISOMER Suppliers

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808732-98-1, MK 0657-CIS-(-)-ISOMERRelated Search:

MK 0657-CIS-(-)-ISOMER

MK-0657

Rislenemdaz

CERC 301

CERC301

CERC-301

1-Piperidinecarboxylic acid, 3-fluoro-4-[(2-pyrimidinylamino)methyl]-, (4-methylphenyl)methyl ester, (3S,4R)-

Rislenemdaz/MK-0657

4-Methylbenzyl (3S,4R)-3-fluoro-4-((pyrimidin-2-ylamino)methyl)piperidine-1-carboxylate

Rislenemdaz, 10 mM in DMSO

808732-98-1