4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline
Appearance- Product Name
- 4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline
- CAS No.
- 612501-52-7
- Chemical Name
- 4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline
- Synonyms
- 4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol;4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline;6-Quinazolinol, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-
- CBNumber
- CB13119911
- Molecular Formula
- C15H11ClFN3O2
- Formula Weight
- 319.72
- MOL File
- 612501-52-7.mol
4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline Property
- Boiling point:
- 458.9±45.0 °C(Predicted)
- Density
- 1.489±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 8.17±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C989233
- Product name
- 4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C989233
- Product name
- 4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- BD632683
- Product name
- 4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol
- Purity
- 97%
- Packaging
- 250mg
- Price
- $11
- Updated
- 2021/12/16
- Product number
- A140948
- Product name
- 4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol
- Purity
- 97%
- Packaging
- 250mg
- Price
- $11
- Updated
- 2021/12/16
- Product number
- BD632683
- Product name
- 4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol
- Purity
- 97%
- Packaging
- 1g
- Price
- $21
- Updated
- 2021/12/16
4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline Chemical Properties,Usage,Production
Appearance
4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline is a light yellow to yellow powder or crystals.
Uses
Applications 4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol is a useful research chemical,it can be used as pharmaceutical intermediates.
Synthesis
740081-22-5
612501-52-7
4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate (200 mg) was used as starting material and dissolved in methanol (2 ml). Subsequently, aqueous ammonia solution (7N, 1 ml) was added to the reaction system. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure to afford the target product 4-((3-chloro-2-fluorophenyl)amino)-7-methoxy-6-ol (white solid, 176 mg, quantitative yield).
References
[1] Patent: CN108329276, 2018, A. Location in patent: Paragraph 0075; 0076
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 18, p. 4455 - 4459
[3] Patent: WO2005/28469, 2005, A1. Location in patent: Page/Page column 59
[4] Patent: WO2005/28470, 2005, A1. Location in patent: Page/Page column 54
[5] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 18, p. 4908 - 4912
4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline manufacturers
- Product
- 4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol 612501-52-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-09-29
- Product
- 4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline 612501-52-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 50kgs/month
- Release date
- 2021-11-19
- Product
- 4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline 612501-52-7
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-10