BAY-1217389

Product Name: BAY-1217389
CAS No.: 1554458-53-5
Chemical Name: BAY-1217389
Synonyms: CS-2361;AY-1217389;BAY-1217389;BAY 1217389 ，S8215;BAY1217389 (BAY 1217389;BAY1217389, 10 mM in DMSO;BAY-1217389 BAY 1217389， BAY 1217389）;Benzamide, N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methyl-
CBNumber: CB13121923
Molecular Formula: C27H24F5N5O3
Formula Weight: 561.5
MOL File: 1554458-53-5.mol

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BAY-1217389 Property

Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 25 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 15 mg/ml
form: A crystalline solid
pka: 14.58±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21660
Product name: BAY 12-17389
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 21660
Product name: BAY 12-17389
Purity: ≥98%
Packaging: 5mg
Price: $142
Updated: 2024/03/01

Cayman Chemical

Product number: 21660
Product name: BAY 12-17389
Purity: ≥98%
Packaging: 10mg
Price: $266
Updated: 2024/03/01

Cayman Chemical

Product number: 21660
Product name: BAY 12-17389
Purity: ≥98%
Packaging: 25mg
Price: $442
Updated: 2024/03/01

TRC

Product number: C992030
Product name: N-Cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide
Packaging: 10mg
Price: $440
Updated: 2021/12/16

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BAY-1217389 Chemical Properties,Usage,Production

Uses

N-Cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide inhibits monopolar spindle 1, which is a serine/threonine/tyrosine kinase involved in cell division. It is also a potential antitumor agent.

in vivo

BAY 1217389 achieves moderate efficacy in monotherapy in tumor xenograft studies. However, in line with its unique mode of action, when combines with paclitaxel, low doses of Mps1 inhibitor reduces paclitaxel-induced mitotic arrest in line with weakening of SAC activity. As a result, combination therapy strongly improves efficacy over paclitaxel or Mps1 inhibitor monotreatment at the respective MTDs in a broad range of xenograft models including those showing acquired or intrinsic paclitaxel-resistance. BAY 1217389 shows good tolerability without adding toxicity to paclitaxel monotherapy^[1].

IC 50

Mps1: 0.63 nM (IC₅₀)

BAY-1217389 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY-1217389 Suppliers

CHINA 73 United States 7 Global 80

Shanghai Boyle Chemical Co., Ltd.

Tel
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Email: sales@boylechem.com
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BOC Sciences

Tel: 1-631-485-4226; 16314854226
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Country: United States
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Dtchem Laboratories,（Gan Su）Co.,Ltd.

Tel: 18993961550 18993966060
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
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Chengdu DingDang Pharmaceutical Co., Ltd.

Tel: 028-86040038 13980902949;
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Email: market@dingdangchem.com
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Shanghai YuanYe Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Beijing Solarbio Science & Tecnology Co., Ltd.

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Amadis Chemical Company Limited

Tel: 571-89925085
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Email: sales@amadischem.com
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Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
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Email: wj520wjxby@126.com
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View Lastest Price from BAY-1217389 manufacturers

Career Henan Chemical Co

Product: BAY1217389 1554458-53-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

1554458-53-5, BAY-1217389Related Search:

BAY-1217389 BAY 1217389， BAY 1217389）

CS-2361

BAY-1217389

Benzamide, N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methyl-

AY-1217389

BAY1217389, 10 mM in DMSO

BAY1217389 (BAY 1217389

BAY 1217389 ，S8215

1554458-53-5

C27H24F5N5O3