AM-0902

Product Name: AM-0902
CAS No.: 1883711-97-4
Chemical Name: AM-0902
Synonyms: AM0902;AM-0902;CS-2717;AM-0902 (AM 0902;AM-0902, 10 mM in DMSO;1-[[3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-7-methylpurin-6-one;1-((3-(4-Chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1H-purin-6(7H)-one;Transient receptor potential channels,TRP Channel,AM 0902,AM-0902,Inhibitor,inhibit,AM0902;1-((3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1,7-dihydro-6H-purin-6-one;1-((3-(4-Chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1H-purin-6(7H)-one , AM-0902
CBNumber: CB13130297
Molecular Formula: C17H15ClN6O2
Formula Weight: 370.79
MOL File: 1883711-97-4.mol

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AM-0902 Property

Melting point:: 190 - 197°C
Boiling point:: 657.3±65.0 °C(Predicted)
Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Very Slightly)
pka: 2.36±0.50(Predicted)
form: Solid
color: White to Off-White

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2985
Product name: AM-0902
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $82.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2985
Product name: AM-0902
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $333
Updated: 2025/07/31

Tocris

Product number: 5914
Product name: AM0902
Purity: ≥98%(HPLC)
Packaging: 10
Price: $130
Updated: 2021/12/16

Tocris

Product number: 5914
Product name: AM0902
Purity: ≥98%(HPLC)
Packaging: 50
Price: $542
Updated: 2021/12/16

TRC

Product number: A634660
Product name: AM0902
Packaging: 1mg
Price: $80
Updated: 2021/12/16

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AM-0902 Chemical Properties,Usage,Production

Uses

AM 0902 is a potent, selective antagonist of TRPA1 (transient receptor potential A1), which has been shown to play a large role in biological pathways associated with pain.

Biological Activity

AM-0902 (AMG0902) is a potent and selective transient receptor potential A1 (TRPA1) antagonist (rat/human TRPA1 IC50 = 71/131 nM against AITC-induced 45Ca2+ influx in respective CHO transfectants with [AITC] = EC90 = 3 μM/hTRPA1 or 35 μM/rTRPA1; human/r at IC50 = 24/20 nM by FLIPR) with little potency against human TRPV1/4, human CYP3A4/2D6, r at TRPV1/3, r at TRPM8, or mouse NaV1.7. AM-0902 effectively reduces AITC-induced flinching in a r at pain model (by 65% and 85%, respectively, with 10 or 30 mg/kg AM-0902 p.o. 1 hr prior to AITC injection) with good pharmacokinetic properties, oral availability and brain exposure (F = 60%, B/P = 0.2; 30 mg/kg p.o. in rats) in vivo.

in vivo

AM-0902 is a potent, selective antagonist of TRPA1 in vivo. AM-0902 has moderate terminal elimination half-life (t_1/2=0.6 h and 2.8 h for rat (0.5 mg/kg, iv), rat (30 mg/kg, oral)). A dose-dependent reduction of allyl isothiocyanate (AITC)-induced flinching is observed for AM-0902, with a significant reduction in flinching observed postdosing of 10 and 30 mg/kg. The unbound plasma concentrations (C_u) at 1 h for the 1, 3, 10, and 30 mg/kg doses are 0.051±0.024 (n=8), 0.19±0.11 (n=8), 0.58±0.35 (n=8), and 2.2±0.40 (n=8) μM, covering the in vitro rat TRPA1 ⁴⁵Ca²⁺ IC₅₀ at 0.72, 2.7, 8.2, and 30.3 fold, respectively. A good exposure-response relationship is observed in this target coverage model. An unbound in vivo IC₅₀ of 0.35 μM, which is in good agreement with the in vitro rat TRPA1 ⁴⁵Ca²⁺ IC₅₀, and unbound in vivo IC₉₀ of 1.7 μM are determined. It is noteworthy that at a dose of 30 mg/kg, AM-0902 engages TRPA1 at concentrations that exceed the in vivo IC₉₀, making it a useful tool for exploration of in vivo models of acute pain^[1].

storage

Store at +4°C

AM-0902 Preparation Products And Raw materials

Raw materials

Preparation Products

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AM-0902 Suppliers

China 56 India 1 United Kingdom 1 United States 9 USA 1 Global 68

Shanghai XingMo Biotechnology Co., Ltd.

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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
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Shanghaizehan biopharma technology co., Ltd.

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Email: sales@zehanbiopharma.com
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
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Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Henan Alfachem Co.,Ltd.

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Chengdu Saint - Kay Biotechnology Co., Ltd.

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Taizhou Crene Biotechnology Co. Ltd.

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1883711-97-4, AM-0902Related Search:

AM0902

AM-0902

1-[[3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-7-methylpurin-6-one

1-[[3-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-6H-purin-6-one

CS-2717

AM-0902 (AM 0902

6H-Purin-6-one, 1-[[3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-

1-({3-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl}methyl)-7-methyl-1,7-dihydro-6H-purin-6-one

1-((3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1,7-dihydro-6H-purin-6-one

Transient receptor potential channels,TRP Channel,AM 0902,AM-0902,Inhibitor,inhibit,AM0902

1-((3-(4-Chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1H-purin-6(7H)-one

1-({3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl}methyl)-7-methyl-6,7-dihydro-1H-purin-6-one

1-((3-(4-Chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1H-purin-6(7H)-one , AM-0902

AM-0902, 10 mM in DMSO

1883711-97-4

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