AM-0902

Product Name: AM-0902
CAS No.: 1883711-97-4
Chemical Name: AM-0902
Synonyms: AM0902;AM-0902;CS-2717;AM-0902 (AM 0902;AM-0902, 10 mM in DMSO;1-[[3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-7-methylpurin-6-one;1-((3-(4-Chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1H-purin-6(7H)-one;Transient receptor potential channels,TRP Channel,AM 0902,AM-0902,Inhibitor,inhibit,AM0902;1-((3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1,7-dihydro-6H-purin-6-one;1-((3-(4-Chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1H-purin-6(7H)-one , AM-0902
CBNumber: CB13130297
Molecular Formula: C17H15ClN6O2
Formula Weight: 370.79
MOL File: 1883711-97-4.mol

More

Less

AM-0902 Property

Melting point:: 190 - 197°C
Boiling point:: 657.3±65.0 °C(Predicted)
Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Very Slightly)
pka: 2.36±0.50(Predicted)
form: Solid
color: White to Off-White
InChI: 1S/C17H15ClN6O2/c1-23-9-19-16-15(23)17(25)24(10-20-16)8-14-21-13(22-26-14)7-4-11-2-5-12(18)6-3-11/h2-3,5-6,9-10H,4,7-8H2,1H3
InChIKey: AWJBWNUUODWOKQ-UHFFFAOYSA-N
SMILES: Clc1ccc(cc1)CCc2n[o]c(n2)C[n]3[c](c4[n](cnc4nc3)C)=O

More

Less

Safety

WGK Germany: WGK 3
HS Code: 2934999090
Storage Class: 11 - Combustible Solids

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2985
Product name: AM-0902
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $88.2
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML2985
Product name: AM-0902
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $357
Updated: 2026/03/19

Tocris

Product number: 5914
Product name: AM0902
Purity: ≥98%(HPLC)
Packaging: 10
Price: $130
Updated: 2021/12/16

Tocris

Product number: 5914
Product name: AM0902
Purity: ≥98%(HPLC)
Packaging: 50
Price: $542
Updated: 2021/12/16

TRC

Product number: A634660
Product name: AM0902
Packaging: 1mg
Price: $80
Updated: 2021/12/16

More

Less

AM-0902 Chemical Properties,Usage,Production

Uses

AM 0902 is a potent, selective antagonist of TRPA1 (transient receptor potential A1), which has been shown to play a large role in biological pathways associated with pain.

Biological Activity

AM-0902 (AMG0902) is a potent and selective transient receptor potential A1 (TRPA1) antagonist (rat/human TRPA1 IC50 = 71/131 nM against AITC-induced 45Ca2+ influx in respective CHO transfectants with [AITC] = EC90 = 3 μM/hTRPA1 or 35 μM/rTRPA1; human/r at IC50 = 24/20 nM by FLIPR) with little potency against human TRPV1/4, human CYP3A4/2D6, r at TRPV1/3, r at TRPM8, or mouse NaV1.7. AM-0902 effectively reduces AITC-induced flinching in a r at pain model (by 65% and 85%, respectively, with 10 or 30 mg/kg AM-0902 p.o. 1 hr prior to AITC injection) with good pharmacokinetic properties, oral availability and brain exposure (F = 60%, B/P = 0.2; 30 mg/kg p.o. in rats) in vivo.

in vivo

AM-0902 is a potent, selective antagonist of TRPA1 in vivo. AM-0902 has moderate terminal elimination half-life (t_1/2=0.6 h and 2.8 h for rat (0.5 mg/kg, iv), rat (30 mg/kg, oral)). A dose-dependent reduction of allyl isothiocyanate (AITC)-induced flinching is observed for AM-0902, with a significant reduction in flinching observed postdosing of 10 and 30 mg/kg. The unbound plasma concentrations (C_u) at 1 h for the 1, 3, 10, and 30 mg/kg doses are 0.051±0.024 (n=8), 0.19±0.11 (n=8), 0.58±0.35 (n=8), and 2.2±0.40 (n=8) μM, covering the in vitro rat TRPA1 ⁴⁵Ca²⁺ IC₅₀ at 0.72, 2.7, 8.2, and 30.3 fold, respectively. A good exposure-response relationship is observed in this target coverage model. An unbound in vivo IC₅₀ of 0.35 μM, which is in good agreement with the in vitro rat TRPA1 ⁴⁵Ca²⁺ IC₅₀, and unbound in vivo IC₉₀ of 1.7 μM are determined. It is noteworthy that at a dose of 30 mg/kg, AM-0902 engages TRPA1 at concentrations that exceed the in vivo IC₉₀, making it a useful tool for exploration of in vivo models of acute pain^[1].

storage

Store at +4°C

AM-0902 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

AM-0902 Suppliers

China 58 India 1 United Kingdom 1 United States 9 USA 1 Global 70

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39999
Advantage: 60

Shanghai XingMo Biotechnology Co., Ltd.

Tel: +86 13524779951; 13524779951
Fax: QQ: 2075692521
Email: 2075692521@qq.com
Country: China
ProdList: 294
Advantage: 55

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 977
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7999
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9550
Advantage: 58

Henan Alfachem Co.,Ltd.

Tel: 0371-55051623 18137891487
Fax: QQ：2853979817
Email: 3983243027@qq.com
Country: China
ProdList: 9803
Advantage: 58

Chengdu Saint - Kay Biotechnology Co., Ltd.

Tel: 028-85157043 15882256948
Email: 676046971@qq.com
Country: China
ProdList: 4188
Advantage: 58

1883711-97-4, AM-0902Related Search:

AM0902

AM-0902

1-[[3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-7-methylpurin-6-one

1-[[3-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-6H-purin-6-one

CS-2717

AM-0902 (AM 0902

6H-Purin-6-one, 1-[[3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-

1-({3-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl}methyl)-7-methyl-1,7-dihydro-6H-purin-6-one

1-((3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1,7-dihydro-6H-purin-6-one

Transient receptor potential channels,TRP Channel,AM 0902,AM-0902,Inhibitor,inhibit,AM0902

1-((3-(4-Chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1H-purin-6(7H)-one

1-({3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl}methyl)-7-methyl-6,7-dihydro-1H-purin-6-one

1-((3-(4-Chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1H-purin-6(7H)-one , AM-0902

AM-0902, 10 mM in DMSO

1883711-97-4

API