Gepotidacin

Product Name: Gepotidacin
CAS No.: 1075236-89-3
Chemical Name: Gepotidacin
Synonyms: Buagafuran;Gepotidacin;GSK-2140944;Gepotidacin (GSK2140944);(R)-2-((4-(((3,4-dihydro-2H-pyrano[2,3-c]pyridin-6-yl)methyl)amino)piperidin-1-yl)methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione;3H,8H-2a,5,8a-Triazaacenaphthylene-3,8-dione, 2-[[4-[[(3,4-dihydro-2H-pyrano[2,3-c]pyridin-6-yl)methyl]amino]-1-piperidinyl]methyl]-1,2-dihydro-, (2R)-;(R)-2-((4-(((3,4-Dihydro-2H-pyrano[2,3-c]pyridin-6-yl)methyl)amino)piperidin-1-yl)methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione , Gepotidacin
CBNumber: CB13133117
Molecular Formula: C24H28N6O3
Formula Weight: 448.52
MOL File: 1075236-89-3.mol

More

Less

Gepotidacin Property

Boiling point:: 661.9±65.0 °C(Predicted)
Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 7.14 mg/mL (15.92 mM)
form: Solid
pka: 7.88±0.10(Predicted)
color: White to yellow
InChIKey: PZFAZQUREQIODZ-LJQANCHMSA-N
SMILES: C1N2C3=C(C=CC2=O)N=CC(=O)N3[C@@H]1CN1CCC(NCC2N=CC3OCCCC=3C=2)CC1

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-6531
Product name: Gepotidacin
Purity: 99.75%
Packaging: 1mg
Price: $132
Updated: 2021/12/16

ChemScene

Product number: CS-6531
Product name: Gepotidacin
Purity: 99.75%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-6531
Product name: Gepotidacin
Purity: 99.75%
Packaging: 10mg
Price: $720
Updated: 2021/12/16

ChemScene

Product number: CS-6531
Product name: Gepotidacin
Purity: 99.75%
Packaging: 50mg
Price: $2340
Updated: 2021/12/16

ChemScene

Product number: CS-6531
Product name: Gepotidacin
Purity: 99.75%
Packaging: 100mg
Price: $3360
Updated: 2021/12/16

More

Less

Gepotidacin Chemical Properties,Usage,Production

Description

Gepotidacin (GSK2140944) is a triazaacenaphtylene developed by GSK and belongs to the class of Novel Bacterial Topoisomerase Inhibitors (NBTI). This new antibiotic is currently being investigated in three phase 3 clinical trials.

Uses

Gepotidacin (GSK2140944) is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor.

Mechanism of action

Gepotidacin's primary mechanism of action involves inhibiting bacterial DNA replication, specifically targeting DNA gyrase (topoisomerase II) and topoisomerase IV. These enzymes are vital for bacterial processes such as replication, transcription, and cell division, as they regulate the topological state of DNA during these activities.

in vivo

GSK2140944 MICs are 0.125 to 0.5 mg/L against the six MRSA isolates. ELF penetration ratios range from 1.1 to 1.4. Observed maximal decreases are 1.1 to 3.1 log10 CFU in neutropenic mice. The mean fAUC/MIC ratios required for stasis and 1-log-unit decreases are 59.3 ± 34.6 and 148.4 ± 83.3, respectively.

References

[1] Farrell DJ, et al. In Vitro Activity of Gepotidacin (GSK2140944) against Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2017 Feb 23;61(3). DOI:10.1128/AAC.02047-16
[2] Biedenbach DJ, et al. In Vitro Activity of Gepotidacin, a Novel Triazaacenaphthylene Bacterial Topoisomerase Inhibitor, against a Broad Spectrum of Bacterial Pathogens. Antimicrob Agents Chemother. 2016 Jan 4;60(3):1918-23. DOI:10.1128/AAC.02820-15
[3] O'Riordan W, et al. Efficacy, Safety, and Tolerability of Gepotidacin (GSK2140944) in the Treatment of Patients with Suspected or Confirmed Gram-Positive Acute Bacterial Skin and Skin Structure Infections. Antimicrob Agents Chemother. 2017 May 24;61(6). DOI:10.1128/AAC.02095-16
[4] So W, et al. Pharmacodynamic Profile of GSK2140944 against Methicillin-Resistant Staphylococcus aureus in a Murine Lung Infection Model. Antimicrob Agents Chemother. 2015 Aug;59(8):4956-61. DOI:10.1128/AAC.00625-15

Gepotidacin Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Gepotidacin Suppliers

China 55 India 2 United States 5 Global 62

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengdrug@163.com; 18616377689
Email: nanfengdrug@163.com
Country: China
ProdList: 20009
Advantage: 58

Shanghai Yunpun industrial Co.,Ltd

Tel: 21-61726900 15202122459
Fax: +86-21-60277507
Email: sales@yunpun.com
Country: China
ProdList: 494
Advantage: 58

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Email: wtx@bayeebio.com
Country: China
ProdList: 239
Advantage: 61

Shanghai Hongboshangyi Pharmaceutical Technology Co. , Ltd.

Tel: 15927323052
Email: shenqianyan@prssh.com
Country: China
ProdList: 999
Advantage: 58

Shanghai Boc Chemical Co.,Ltd

Tel: 021-34975603-808 18721111801
Fax: +86-21-34975602-805
Email: sales@bocpharma.com
Country: China
ProdList: 1009
Advantage: 64

ChemCell Biomedicine Co.,Ltd.

Tel: 020-13556033878 2965585218 13556033878
Fax: 0086-0757-85406358
Email: chemcell@hotmail.com
Country: China
ProdList: 369
Advantage: 52

Shenzhen HwaGen Pharmaceutical Co.,Ltd

Tel: 17722620669
Fax: 0752-5319394
Email: liangcong.yi@rafflespt.com
Country: China
ProdList: 279
Advantage: 58

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Xiamen Halosyntech Co., Ltd

Tel: 0592-6688068 18106901346
Fax: 0592-6686768
Email: qbl2015@halolife.cn
Country: China
ProdList: 127
Advantage: 55

More

Less

View Lastest Price from Gepotidacin manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: Gepotidacin 1075236-89-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-11-12

RongNa Biotechnology Co.,Ltd

Product: Gepotidacin 1075236-89-3
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 1 ton
Release date: 2025-08-20

1075236-89-3, GepotidacinRelated Search:

Gepotidacin

Buagafuran

GSK-2140944

Gepotidacin (GSK2140944)

3H,8H-2a,5,8a-Triazaacenaphthylene-3,8-dione, 2-[[4-[[(3,4-dihydro-2H-pyrano[2,3-c]pyridin-6-yl)methyl]amino]-1-piperidinyl]methyl]-1,2-dihydro-, (2R)-

(R)-2-((4-(((3,4-dihydro-2H-pyrano[2,3-c]pyridin-6-yl)methyl)amino)piperidin-1-yl)methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

(R)-2-((4-(((3,4-Dihydro-2H-pyrano[2,3-c]pyridin-6-yl)methyl)amino)piperidin-1-yl)methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione , Gepotidacin

1075236-89-3