ChemicalBook > CAS DataBase List > FIIN-3

FIIN-3

Product Name
FIIN-3
CAS No.
1637735-84-2
Chemical Name
FIIN-3
Synonyms
FIN-3;FIIN-3;CS-2331;FIIN3; FIIN 3;FIIN3; FIIN 3; FIIN-3;Inhibitor,FIIN 3,FIIN-3,HER1,FIIN3,ErbB-1,Epidermal growth factor receptor,inhibit,Fibroblast growth factor receptor,EGFR,FGFR;2-Propenamide, N-[4-[[[[(2,6-dichloro-3,5-dimethoxyphenyl)amino]carbonyl][6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]-
CBNumber
CB13133445
Molecular Formula
C34H36Cl2N8O4
Formula Weight
691.61
MOL File
1637735-84-2.mol
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FIIN-3 Property

Boiling point:
909.4±65.0 °C(Predicted)
Density 
1.379±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Acetonitrile: sparingly soluble; Methanol: sparingly soluble
form 
A crystalline solid
pka
10.78±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20709
Product name
FIIN-3
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
20709
Product name
FIIN-3
Purity
≥98%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
20709
Product name
FIIN-3
Purity
≥98%
Packaging
10mg
Price
$283
Updated
2024/03/01
Cayman Chemical
Product number
20709
Product name
FIIN-3
Purity
≥98%
Packaging
25mg
Price
$618
Updated
2024/03/01
TRC
Product number
F336510
Product name
FIIN-​3
Packaging
1mg
Price
$145
Updated
2021/12/16
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FIIN-3 Chemical Properties,Usage,Production

Description

FIIN-3 is an inhibitor of FGF receptors (FGFRs; IC50s = 13, 21, 31, and 35 nM for recombinant FGFR1-4, respectively). It is selective for FGFRs over a panel of 456 kinases at a concentration of 1 μM, however, it does inhibit EGFR (IC50 = 204 nM). FIIN-3 inhibits growth of Ba/F3 cells that are dependent on the kinase activity of wild-type FGFR1-4 as well as gatekeeper mutant FGFR2 and FGFR3 (EC50s = <1-69 nM) and inhibits FGFR-dependent signaling in a concentration-dependent manner in FGFR2TEL/V564M-dependent Ba/F3 cells. FIIN-3 also inhibits growth in a panel of cancer cell lines (EC50s = 1.4-499 nM).

Uses

FIIN-?3 is FGFR inhibitor. It can be used in synthetic preparation and complex with EGFR kinase of crystal structure; development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.

Definition

ChEBI: N-[4-[[[(2,6-dichloro-3,5-dimethoxyanilino)-oxomethyl]-[6-[4-(4-methyl-1-piperazinyl)anilino]-4-pyrimidinyl]amino]methyl]phenyl]-2-propenamide is a member of piperazines.

FIIN-3 Preparation Products And Raw materials

Raw materials

Preparation Products

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FIIN-3 Suppliers

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1637735-84-2, FIIN-3Related Search:


  • FIIN3; FIIN 3
  • FIIN3; FIIN 3; FIIN-3
  • CS-2331
  • FIIN-3
  • FIN-3
  • 2-Propenamide, N-[4-[[[[(2,6-dichloro-3,5-dimethoxyphenyl)amino]carbonyl][6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]-
  • Inhibitor,FIIN 3,FIIN-3,HER1,FIIN3,ErbB-1,Epidermal growth factor receptor,inhibit,Fibroblast growth factor receptor,EGFR,FGFR
  • 1637735-84-2