cpi-637

Product Name: cpi-637
CAS No.: 1884712-47-3
Chemical Name: cpi-637
Synonyms: CPI-637 >=98% (HPLC);CPI-637;CPI 637;CPI637;Inhibitor,inhibit,HAT,Epigenetic Reader Domain,CPI637,CPI-637,Histone Acetyltransferase,HATs;(R)-4-Methyl-6-(1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one;2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-, (4R)-
CBNumber: CB13139528
Molecular Formula: C22H22N6O
Formula Weight: 386.45
MOL File: 1884712-47-3.mol

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cpi-637 Property

Boiling point:: 689.2±55.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥19.3 mg/mL in DMSO with gentle warming
form: solid
pka: 14.62±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23500
Product name: CPI-637
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 23500
Product name: CPI-637
Purity: ≥98%
Packaging: 5mg
Price: $122
Updated: 2024/03/01

Cayman Chemical

Product number: 23500
Product name: CPI-637
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 23500
Product name: CPI-637
Purity: ≥98%
Packaging: 25mg
Price: $343
Updated: 2024/03/01

ApexBio Technology

Product number: B7801
Product name: CPI-637
Packaging: 50mg
Price: $348
Updated: 2021/12/16

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cpi-637 Chemical Properties,Usage,Production

Description

CPI-637 is an inhibitor of cyclic-AMP response element binding protein (CBP) and adenoviral E1A binding protein of 300 kDa (EP300), a homologous pair of bromodomain-containing proteins (IC₅₀s = 30 and 51 nM in a time-resolved-FRET (TR-FRET) assay). It is selective for CBP and EP300 over the BET family of bromodomains (IC₅₀s = >10 μM), however, CPI-637 is active at bromodomain BRD9 (IC₅₀ = 0.73 μM). CPI-637 also inhibits MYC expression (EC₅₀ = 0.6 μM) in AMO-1 cells.

in vitro

previous study found that cpi-637 was potent against ep300, and its opposite enantiomer showed a over 200-fold loss in potency. moreover, the biochemical potency of cpi-637 translated well into cells with cbp bret ec50 of 0.3 μm, and cpi-637 demonstrated a more than 700-fold selectivity over the bet family of bromodomains. in addition, cpi-637 was also highly selective against other bromodomains, showing substantial biochemical activity only against brd9. furthermore, it was found that cpi-637 was able to inhibit the expression of myc with an ec50 of 0.60 μm in a cellular assay,. [1].

IC 50

0.03 and 11.0 μm for cbp/ep300 and brd4, respectively.

References

[1] taylor, a. m. et al. fragment-based discovery of a selective and cell-active benzodiazepinone cbp/ep300 bromodomain inhibitor (cpi-637). acs medicinal chemistry letters 7, 531-536, doi:10.1021/acsmedchemlett.6b00075 (2016).

cpi-637 Preparation Products And Raw materials

Raw materials

Preparation Products

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cpi-637 Suppliers

China 46 India 1 United States 8 Global 55

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1884712-47-3, cpi-637Related Search:

CPI-637;CPI 637;CPI637

2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-, (4R)-

CPI-637 >=98% (HPLC)

(R)-4-Methyl-6-(1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one

Inhibitor,inhibit,HAT,Epigenetic Reader Domain,CPI637,CPI-637,Histone Acetyltransferase,HATs

1884712-47-3

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