ChemicalBook > CAS DataBase List > (4aS,9bR)-6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole

(4aS,9bR)-6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole

Uses

Product Name: (4aS,9bR)-6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole
CAS No.: 1059630-07-7
Chemical Name: (4aS,9bR)-6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole
Synonyms: EOS-60906;Lumateperone Intermediate;6-bromo-2,3,4,4a(S),5,9b(R)-hexahydropyrido[4,3-b]indole;(4aS,9bR)-6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]in...;(4aS,9bR)-6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole;1H-Pyrido[4,3-b]indole, 6-bromo-2,3,4,4a,5,9b-hexahydro-, (4aS,9bR)-;N-[2-[benzyl(thiophen-2-ylmethyl)amino]-2-oxoethyl]-2,4-dimethoxy-N-(2-morpholin-4-ylethyl)benzamide
CBNumber: CB13142274
Molecular Formula: C11H13BrN2
Formula Weight: 253.14
MOL File: 1059630-07-7.mol

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(4aS,9bR)-6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole Property

Boiling point:: 338.4±42.0 °C(Predicted)
Density: 1.416±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 10.02±0.20(Predicted)
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C11H13BrN2/c12-9-3-1-2-7-8-6-13-5-4-10(8)14-11(7)9/h1-3,8,10,13-14H,4-6H2/t8-,10-/m0/s1
InChIKey: LPBJHSPFSUDRSY-WPRPVWTQSA-N
SMILES: N1C2=C(C=CC=C2Br)[C@]2([H])CNCC[C@]12[H]

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 3889DP
Product name: (4As,9bR)-6-Bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole
Packaging: 1g
Price: $1288
Updated: 2021/12/16

Alichem

Product number: 1059630077
Product name: (4aS,9bR)-6-Bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole
Packaging: 5g
Price: $2059.2
Updated: 2021/12/16

Alichem

Product number: 1059630077
Product name: (4aS,9bR)-6-Bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole
Packaging: 10g
Price: $3640
Updated: 2021/12/16

Ambeed

Product number: A122747
Product name: (4aS,9bR)-6-Bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole
Purity: 97%
Packaging: 100mg
Price: $66
Updated: 2021/12/16

Ambeed

Product number: A122747
Product name: (4aS,9bR)-6-Bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole
Purity: 97%
Packaging: 250mg
Price: $100
Updated: 2021/12/16

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(4aS,9bR)-6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole Chemical Properties,Usage,Production

Uses

(4aS,9bR)-6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-B]indole is a heterocyclic organic compound that can be used as a pharmaceutical intermediate.

Synthesis

1059630-12-4

1059630-07-7

Example 2: Preparation of [4aS,9bR]-6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole: 6-bromo-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride (8.48 mmol) was mixed with trifluoroacetic acid (630 mL) and triethylsilane (172 mL). The reaction mixture was stirred at room temperature for 19 h under nitrogen protection. Excess trifluoroacetic acid and triethylsilane were removed under vacuum. Hexane (550 mL) was added to the residue, stirred at room temperature for 1 hour and decanted. Hexane (250 mL) was added repeatedly and stirred for 1 hour and decanted. The residual oily mass was adjusted to pH=10 by addition of 2N sodium hydroxide solution and subsequently extracted with dichloromethane. The organic layers were combined, washed with brine and dried over anhydrous sodium sulfate. Enantioseparation of [4aS,9bR]-6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole can be accomplished by dissolving the racemate 6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole (8 g, 31.6 mmol) in methanol (160 mL) in a 50 °C oil bath in batches (R)-mandelic acid (4.8 g, 31.6 mmol) was added. After stirring for a few minutes, ether (80 mL) was added dropwise, cooled to room temperature, and filtered to obtain a white precipitate (R-mandelate, 3.7 g). HPLC analysis showed >99% ee. The filtrate was concentrated, treated with 1N sodium hydroxide (100 mL), and extracted with dichloromethane (2 x 50 mL). The organic layers were combined, washed with brine, dried over sodium sulfate and concentrated to give an oil (5.59 g). It was dissolved in methanol (90 mL), (S)-(+)-mandelic acid (3.53 g, 23.2 mmol) was added in batches, stirred for a few minutes and then ether (45 mL) was added dropwise, cooled to room temperature, and filtered to give a white precipitate (S-mandelate, 4.19 g).HPLC analysis showed >99% ee. R-mandelate: [α]D25 = -98.1; S-mandelate acid salt: [α]D25 = +102 (solvent: DMSO). Alternative methods allow splitting in a mixture of methanol and tert-butyl methyl ether (MTBE). Alternatively, the racemate 6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole (9.61 g, 38.0 mmol) was dissolved in methanol (190 mL), and (S)-(+)-mandelic acid (5.78 g, 38.0 mmol) was added in batches with stirring for a few minutes and then added dropwise with ether (95 mL) and cooled to room temperature. Filtration yielded a white precipitate (S-mandelate, 4 g). HPLC analysis showed >99% ee. Large-scale enantiomeric separation can be achieved by dissolving racemic 6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole (1710 g, 6.21 mol) in methanol (24 L), heating to 40 °C, and adding a one-time dose of (R)-(-)- mandelic acid (944 g, 6.2 mol), cooled and added MTBE (13 L), aged with stirring at room temperature for 30-40 h. A white to off-white precipitate was obtained by filtration (Int-2 R-mandelate, 580 g, 23%). Chiral HPLC showed >99% ee. The filtrate was concentrated, alkalized and extracted with dichloromethane, dried and concentrated to give the free base (~1150 g). It was dissolved in methanol (17 L), (S)-(+)-mandelic acid (692 g, 4.55 mol) was added, MTBE (8.5 L) was added, and aged at room temperature for 30-40 h. S-mandelate (828 g, 33%) was obtained by filtration. Chiral HPLC showed >99% ee. R-mandelate: [α]D25 = -98.1; S-mandelate: [α]D25 = +102 (solvent: DMSO). Chiral HPLC conditions: ChiralPak AD-H column, 250 × 4.6 mm, 30% isopropanol/hexane (containing 0.1% diethylamine), flow rate 0.8 mL/min, UV detection 254 nm.

References

[1] Patent: WO2008/112280, 2008, A1. Location in patent: Page/Page column 82-85
[2] Drugs of the Future, 2015, vol. 40, # 10, p. 643 - 650

(4aS,9bR)-6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole Preparation Products And Raw materials

Raw materials

Preparation Products

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1059630-07-7, (4aS,9bR)-6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoleRelated Search:

LUMAT-005 1H-Pyrido[4,3-b]indole, 6-bromo-2,3,4,5-tetrahydro-, hydrochloride (1:1)

(4aS,9bR)-6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole

N-[2-[benzyl(thiophen-2-ylmethyl)amino]-2-oxoethyl]-2,4-dimethoxy-N-(2-morpholin-4-ylethyl)benzamide

EOS-60906

Lumateperone Intermediate

6-bromo-2,3,4,4a(S),5,9b(R)-hexahydropyrido[4,3-b]indole

1H-Pyrido[4,3-b]indole, 6-bromo-2,3,4,4a,5,9b-hexahydro-, (4aS,9bR)-

(4aS,9bR)-6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]in...

1059630-07-7