ChemicalBook > CAS DataBase List > 4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid

4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid

Product Name: 4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid
CAS No.: 1370448-25-1
Chemical Name: 4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid
Synonyms: Clesacostat;PF-05221304;EOS-62091;PF-07055341;CAS:1370448-25-1;PF-05221304 ，S6145;STAT5 Inhibitor III;PF 05221304,PF05221304;PF-05221304(Clesacostat);PF-05221304 + PF-06865571
CBNumber: CB13142744
Molecular Formula: C28H30N4O5
Formula Weight: 502.56
MOL File: 1370448-25-1.mol

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4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid Property

Boiling point:: 745.3±60.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 100 mg/mL (198.98 mM);Ethanol: 5 mg/mL (9.95 mM)
pka: 3.93±0.10(Predicted)
Water Solubility: Water: Insoluble
InChIKey: LXZMHBHEXAELHH-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C(C2=NC(OC)=CC(C(N3CCC4(CC3)CC(=O)C3=C(C4)C=NN3C(C)C)=O)=C2)C=C1

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Hazard and Precautionary Statements (GHS)

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4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid Chemical Properties,Usage,Production

Description

PF-05221304 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 12.4 and 8.7 nM, respectively).1 It inhibits de novo lipid synthesis (IC50 = 61 nM) and increases fatty acid oxidation in primary human hepatocytes. PF-05221304 reduces the accumulation of triglycerides composed of de novo-derived fatty acids but not dietary essential fatty acids in primary human hepatocytes. In vivo, PF-05221304 (10 and 100 mg/kg) reduces hepatic malonyl-CoA production and de novo lipogenesis in rats. It reduces hepatic fibrosis, alanine transaminase (ALT) and aspartate aminotransferase (AST) levels, and triglyceride accumulation in a rat model of non-alcoholic steatohepatitis (NASH) induced by a choline-deficient and high-fat diet (CDAHFD).WARNING This product is not for human or veterinary use.

4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid Preparation Products And Raw materials

Raw materials

Preparation Products

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1370448-25-1, 4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacidRelated Search:

4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid

EOS-62091

PF-05221304

Benzoic acid, 4-[6-methoxy-4-[[1,4,6,7-tetrahydro-1-(1-methylethyl)-7-oxospiro[5H-indazole-5,4'-piperidin]-1'-yl]carbonyl]-2-pyridinyl]-

Clesacostat

PF-05221304(Clesacostat)

STAT5 Inhibitor III

PF 05221304,PF05221304

4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidin]-1'-ylcarbonyl)-6-methoxypyridin-2-yl)benzoic acid

PF-05221304, 10 mM in DMSO

PF-05221304 + PF-06865571

PF-07055341

PF-05221304 ，S6145

CAS:1370448-25-1

1370448-25-1