5-chloro-3-nitro-1H-pyrazole
- Product Name
- 5-chloro-3-nitro-1H-pyrazole
- CAS No.
- 1369959-12-5
- Chemical Name
- 5-chloro-3-nitro-1H-pyrazole
- Synonyms
- EOS-61386;3-chloro-5-nitro-1H-pyrazole;5-chloro-3-nitro-1H-pyrazole;1H-Pyrazole, 3-chloro-5-nitro-
- CBNumber
- CB13142830
- Molecular Formula
- C3H2ClN3O2
- Formula Weight
- 147.52
- MOL File
- 1369959-12-5.mol
5-chloro-3-nitro-1H-pyrazole Property
- Boiling point:
- 359.0±22.0 °C(Predicted)
- Density
- 1.740±0.06 g/cm3(Predicted)
- storage temp.
- Store at room temperature
- pka
- 5.36±0.10(Predicted)
- Appearance
- Yellow to brown Solid
N-Bromosuccinimide Price
- Product number
- CS-W000620
- Product name
- 3-chloro-5-nitro-1H-pyrazole
- Packaging
- 100mg
- Price
- $328
- Updated
- 2021/12/16
- Product number
- 2536AQ
- Product name
- 5-chloro-3-nitro-1H-pyrazole;
- Packaging
- 1g
- Price
- $1749.2
- Updated
- 2021/12/16
- Product number
- CM249088
- Product name
- 3-Chloro-5-nitro-1H-pyrazole
- Purity
- 95+%
- Packaging
- 5g
- Price
- $2115
- Updated
- 2021/12/16
- Product number
- CM249088
- Product name
- 3-Chloro-5-nitro-1H-pyrazole
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $149
- Updated
- 2021/12/16
- Product number
- CM249088
- Product name
- 3-Chloro-5-nitro-1H-pyrazole
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $219
- Updated
- 2021/12/16
5-chloro-3-nitro-1H-pyrazole Chemical Properties,Usage,Production
Synthesis
1369959-11-4
1369959-12-5
General procedure for the synthesis of 3-chloro-5-nitro-1H-pyrazole using 3-chloro-1-nitro-1H-pyrazole as starting material: 3-chloro-1-nitro-1H-pyrazole (4.0 g, 27 mmol) was dissolved in anisole (20 mL), and the resulting solution was transferred to an autoclave. The reaction system was heated to 140 °C and the reaction was continuously stirred at this temperature overnight. Upon completion of the reaction, the reaction mixture was cooled to 0 °C and subsequently diluted with hexane (200 mL) and stirring was continued at 0 °C for 30 min. The solid product was isolated by filtration and the solid was washed with cold hexane (10 mL) and dried to give the target compound 3-chloro-5-nitro-1H-pyrazole (2.1 g, 51% yield) as a yellow solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 14.96 (broad single peak, 1H), 7.30 (single peak, 1H).
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3036 - 3048
[2] Patent: WO2018/85247, 2018, A1. Location in patent: Paragraph 00296; 00299
5-chloro-3-nitro-1H-pyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
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