ChemicalBook > CAS DataBase List > SYP-5

SYP-5

Product Name: SYP-5
CAS No.: 1384268-04-5
Chemical Name: SYP-5
Synonyms: SYP-5;SYP5; SYP 5;SYP-5 >=98% (HPLC);SYP-5, 10 mM in DMSO;(E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(thiophen-2-yl)prop-2-en-1-one;2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-, (2E)-;SYP-5,Inhibitor,HIFs,Hypoxia-inducible factors,SYP5,inhibit,HIF-PH,SYP 5,HIF/HIF Prolyl-Hydroxylase
CBNumber: CB13145907
Molecular Formula: C18H16O3S
Formula Weight: 312.38
MOL File: 1384268-04-5.mol

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SYP-5 Property

Boiling point:: 502.0±50.0 °C(Predicted)
Density: 1.263±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF:30.0(Max Conc. mg/mL);96.04(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.96(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);80.03(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);3.2(Max Conc. mM)
form: A solid
pka: 7.12±0.40(Predicted)
color: Yellow to orange

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6108
Product name: SYP-5
Purity: 99.68%
Packaging: 5mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-6108
Product name: SYP-5
Purity: 99.68%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-6108
Product name: SYP-5
Purity: 99.68%
Packaging: 50mg
Price: $490
Updated: 2021/12/16

ChemScene

Product number: CS-6108
Product name: SYP-5
Purity: 99.68%
Packaging: 100mg
Price: $900
Updated: 2021/12/16

DC Chemicals

Product number: DC10436
Product name: SYP-5
Purity: >98%
Packaging: 250mg
Price: $1250
Updated: 2021/12/16

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SYP-5 Chemical Properties,Usage,Production

Uses

SYP-5 is a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis.

Biological Activity

SYP-5, an inhibitor of Hypoxia-inducible factor-1 (HIF-1), inhibits tumor cell migration and invasion and tumor angiogenesis.

in vitro

SYP-5 inhibits hypoxia-induced upregulation of HIF-1. It inhibits HIF-1 and downstream gene expression in Hep3B and Bcap37 cells. It inhibits tumor cell migration and invasion, as well as tumor angiogenesis, which are mediated by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway. The proteins of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 that are targets of HIF-1, are down -regulated by SYP-5.

target

Target	Value
HIF-1 ()

References

[1] Wang LH, et al. SYP-5, a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis. Eur J Pharmacol. 2016 Nov 15;791:560-568. DOI:10.1016/j.ejphar.2016.09.027

SYP-5 Preparation Products And Raw materials

Raw materials

Preparation Products

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1384268-04-5, SYP-5Related Search:

SYP-5

SYP5; SYP 5

2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-, (2E)-

SYP-5 >=98% (HPLC)

SYP-5,Inhibitor,HIFs,Hypoxia-inducible factors,SYP5,inhibit,HIF-PH,SYP 5,HIF/HIF Prolyl-Hydroxylase

(E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(thiophen-2-yl)prop-2-en-1-one

SYP-5, 10 mM in DMSO

1384268-04-5