AM2394

Uses

Product Name: AM2394
CAS No.: 1442684-77-6
Chemical Name: AM2394
Synonyms: AM2394;CS-2242;AM2394 ，S3527;AM2394;AM 2394;AM-2394, 10 mM in DMSO;AM-2394,Hexokinase D,Inhibitor,AM 2394,Glucokinase,inhibit,Hexokinase IV;N-[6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methylurea;1-(6'-(2-hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3'-bipyridin]-6-yl)-3-methylurea;1-[5-[6-(2-hydroxy-2-methylpropoxy)pyridin-3-yl]-4-(5-methylpyridin-3-yl)oxypyridin-2-yl]-3-methylurea;Urea, N-[6'-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methyl-
CBNumber: CB13145987
Molecular Formula: C22H25N5O4
Formula Weight: 423.46
MOL File: 1442684-77-6.mol

More

Less

AM2394 Property

Boiling point:: 588.8±50.0 °C(Predicted)
Density: 1.266±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml
form: A crystalline solid
pka: 12.66±0.70(Predicted)
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 20992
Product name: AM2394
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 20992
Product name: AM2394
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 20992
Product name: AM2394
Packaging: 10mg
Price: $283
Updated: 2024/03/01

Cayman Chemical

Product number: 20992
Product name: AM2394
Packaging: 25mg
Price: $618
Updated: 2024/03/01

Tocris

Product number: 6034
Product name: AM2394
Purity: ≥98%(HPLC)
Packaging: 10
Price: $210
Updated: 2021/12/16

More

Less

AM2394 Chemical Properties,Usage,Production

Uses

AM 2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates GK with an EC50 of 60 nM.

Uses

AM 2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates GK with an EC50 of 60 nM.

in vivo

AM-2394, a structurally distinct glucokinase activator that displays a robust reduction in plasma glucose during an oral glucose tolerance test (OGTT) in ob/ob mice at a dose of 3 mg/kg. AM-2394 increases the affinity of glucokinase (GK) for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. AM-2394 exhibits good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability, allowing for further evaluation in animal models^[1].

AM2394 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

AM2394 Suppliers

China 78 United Kingdom 1 United States 10 Global 89

Wuhan rheniuhui Biotechnology Co., Ltd

Tel: 18062115889
Fax: qq405368533
Email: 405368533@qq.com
Country: China
ProdList: 197
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7245
Advantage: 62

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Nanjing Dulai Biotechnology Co., Ltd.

Tel: 025-84699383-8003;025-846993838003-8003 18013301593;18013301590
Fax: 025-84699383-8003
Email: njduly@126.com
Country: China
ProdList: 3293
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 40000
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4817
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 979
Advantage: 55

Guangzhou Zhiya Chemdrugs Co.,Ltd

Tel: 18122150900
Fax: QQ:2869377561
Email: sculk28@163.com
Country: China
ProdList: 646
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

1442684-77-6, AM2394Related Search:

AM2394

1-(6'-(2-hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3'-bipyridin]-6-yl)-3-methylurea

AM2394;AM 2394

CS-2242

N-[6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methylurea

Urea, N-[6'-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methyl-

AM-2394,Hexokinase D,Inhibitor,AM 2394,Glucokinase,inhibit,Hexokinase IV

AM-2394, 10 mM in DMSO

AM2394 ，S3527

1-[5-[6-(2-hydroxy-2-methylpropoxy)pyridin-3-yl]-4-(5-methylpyridin-3-yl)oxypyridin-2-yl]-3-methylurea

1442684-77-6

API