EPPTB
- Product Name
- EPPTB
- CAS No.
- 1110781-88-8
- Chemical Name
- EPPTB
- Synonyms
- EPPTB;RO5212773);Ro 5212773 (EPPTB);EPPTB (RO 5212773;N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide;N-(3-Ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)benzamide;Benzamide, N-(3-ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)-;Ro-5212773,Inhibitor,Ro 5212773,neuronal,inhibit,Ro5212773,mesolimbic,system,TAAR1,GPCR
- CBNumber
- CB13146292
- Molecular Formula
- C20H21F3N2O2
- Formula Weight
- 378.39
- MOL File
- 1110781-88-8.mol
EPPTB Property
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 25 mg/ml).
- form
- solid
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- SML1350
- Product name
- EPPTB
- Purity
- ≥95% (HPLC)
- Packaging
- 5MG
- Price
- $100
- Updated
- 2024/03/01
- Product number
- SML1350
- Product name
- EPPTB
- Purity
- ≥95% (HPLC)
- Packaging
- 25MG
- Price
- $393
- Updated
- 2024/03/01
- Product number
- 4518
- Product name
- EPPTB
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $168
- Updated
- 2021/12/16
- Product number
- 4518
- Product name
- EPPTB
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $699
- Updated
- 2021/12/16
- Product number
- 255257
- Product name
- EPPTB
- Packaging
- 10mg
- Price
- $409
- Updated
- 2021/12/16
EPPTB Chemical Properties,Usage,Production
Description
EPPTB (1110781-88-8) is a novel selective trace amine associated receptor 1 (TAAR1) antagonist (IC50=28 nM at mouse TAAR1).1,2 A useful tool for probing the physiologic role of TAAR1.3-6
Uses
EPPTB is a selective antagonist of the trace amine-associated 1 (TA1) receptor, increasing the firing frequency of dopamine (DA) neurons in the ventral tegmental area. This makes it a promising drug target for neurodegenerative disorders.
storage
Store at +4°C
References
1) Bradaia et al. (2009), The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system; Proc. Natl. Acad. Sci. USA, 106 20081 2) Stalder et al. (2011), Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): discovery of EPPTB (RO5212773); Bioorg. Med. Chem. Lett., 21 1227 3) Zhang et al. (2018), Striatal Tyrosine Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine; Front. Pharmacol., 9 166 4) De Greggrio et al. (2016), The hallucinogen d-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT1A, D2 and TAAR1 receptors; Pharmacol. Res., 113 81 5) Cichero et al. (2014), Further insights into the pharmacology of the human trace amine-associated receptors: discovery of the novel ligands for TAAR1 by a virtual screening approach; Chem. Biol. Drug Des., 84 712 6) Liu et al. (2014), Ractopamine, a livestock feed additive, is a full agonist at trace amine-associated receptor 1; J. Pharmacol. Exp. Ther. 350 124
EPPTB Preparation Products And Raw materials
Raw materials
Preparation Products
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