OTX 008

Product Name: OTX 008
CAS No.: 286936-40-1
Chemical Name: OTX 008
Synonyms: PTX 008;Calixarene 0118;OTX008, 10 mM in DMSO;OTX008 (Calixarene 0118;Calix[4]arene compound 0118;OTX008 (Synonyms: Calixarene 0118;PTX 008,OTX 008,Galectin,Calixarene0118,PTX-008,inhibit,OTX008,Calixarene-0118,OTX-008,Inhibitor;2,2',2'',2'''-(1,3,5,7(1,3)-Tetrabenzenacyclooctaphane-12,32,52,72-tetrayltetrakis(oxy))tetrakis(N-(2-(dimethylamino)ethyl)acetamide);2,2',2'',2'''-(1,3,5,7(1,3)-Tetrabenzenacyclooctaphane-12,32,52,72-tetrayltetrakis(oxy))tetrakis(N-(2-(dimethylamino)ethyl)acetamide);Acetamide, 2,2',2'',2'''-[pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaene-25,26,27,28-tetrayltetrakis(oxy)]tetrakis[N-[2-(dimethylamino)ethyl]-
CBNumber: CB13146348
Molecular Formula: C52H72N8O8
Formula Weight: 937.18
MOL File: 286936-40-1.mol

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OTX 008 Property

Boiling point:: 1143.4±65.0 °C(Predicted)
Density: 1.155±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 1 mg/ml; DMSO: 2 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 0.5 mg/ml
form: A crystalline solid
pka: 13.84±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23130
Product name: OTX008
Purity: ≥98%
Packaging: 500μg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 23130
Product name: OTX008
Purity: ≥98%
Packaging: 1mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 23130
Product name: OTX008
Purity: ≥98%
Packaging: 5mg
Price: $535
Updated: 2024/03/01

Cayman Chemical

Product number: 23130
Product name: OTX008
Purity: ≥98%
Packaging: 10mg
Price: $936
Updated: 2024/03/01

ChemScene

Product number: CS-0016572
Product name: OTX008
Purity: 99.36%
Packaging: 25mg
Price: $590
Updated: 2021/12/16

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OTX 008 Chemical Properties,Usage,Production

Biological Activity

OTX008 (Calixarene 0118, PTX008), a calixarene derivative, is a selective inhibitor of galectin-1 (Gal1) with antitumor activity.

in vivo

OTX008 inhibits growth of A2780-1A9 xenografts. OTX008 treatment is associated with down-regulation of Gal1 and Ki67 in treated tumours, as well as decreased microvessel density and VEGFR2 expression. Finally, combination studies show OTX008 synergy with several cytotoxic and targeted therapies, principally when OTX008 is administered first.

target

Target	Value
galectin-1 ()

OTX 008 Preparation Products And Raw materials

Raw materials

Preparation Products

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OTX 008 Suppliers

China 36 United States 4 Global 40

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
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ChemStrong Scientific Co.,Ltd

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Shanghai EFE Biological Technology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Angel Pharmatech, Ltd.

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Guangdong wengjiang Chemical Reagent Co., Ltd.

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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Fan De(Beijing) Biotechnology Co., Ltd.

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Shanghai Meiquan Chemical Technology Co., Ltd.

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286936-40-1, OTX 008Related Search:

OTX008 (Calixarene 0118

OTX008 (Synonyms: Calixarene 0118

Calix[4]arene compound 0118

Calixarene 0118

PTX 008

Acetamide, 2,2',2'',2'''-[pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaene-25,26,27,28-tetrayltetrakis(oxy)]tetrakis[N-[2-(dimethylamino)ethyl]-

2,2',2'',2'''-(1,3,5,7(1,3)-Tetrabenzenacyclooctaphane-12,32,52,72-tetrayltetrakis(oxy))tetrakis(N-(2-(dimethylamino)ethyl)acetamide)

PTX 008,OTX 008,Galectin,Calixarene0118,PTX-008,inhibit,OTX008,Calixarene-0118,OTX-008,Inhibitor

2,2',2'',2'''-(1,3,5,7(1,3)-Tetrabenzenacyclooctaphane-12,32,52,72-tetrayltetrakis(oxy))tetrakis(N-(2-(dimethylamino)ethyl)acetamide)

OTX008, 10 mM in DMSO

286936-40-1

C52H72N8O8