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RK-33

Product Name
RK-33
CAS No.
1070773-09-9
Chemical Name
RK-33
Synonyms
RX33;RX 33;RK-33;RX33; RX 33;3,7-Bis(4-methoxybenzyl)-3,7-dihydro-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one;3,7-Bis(4-methoxybenzyl)-3,7-dihydro-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one;3,7-Bis(4-methoxybenzyl)-3,7-dihydro-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one[RK33;2H-Diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one, 3,7-dihydro-3,7-bis[(4-methoxyphenyl)methyl]-
CBNumber
CB13146621
Molecular Formula
C23H20N6O3
Formula Weight
428.44
MOL File
1070773-09-9.mol
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RK-33 Property

Melting point:
175-177 °C
Boiling point:
677.0±65.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (up to 20 mg/ml).
form 
solid
pka
3.40±0.20(Predicted)
color 
Yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
R545500
Product name
RK33
Packaging
5mg
Price
$140
Updated
2021/12/16
ApexBio Technology
Product number
B7810
Product name
RK-33
Packaging
5mg
Price
$124
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0004772
Product name
[1,3]DIAZEPIN-2-ONE, 3,7-DIHYDRO-3,7-BIS[(4-METHOXYPHENYL)METHYL]-2H-DIIMIDAZO
Purity
95.00%
Packaging
5MG
Price
$505.62
Updated
2021/12/16
Ambeed
Product number
A179326
Product name
RK-33
Purity
98+%
Packaging
50mg
Price
$940
Updated
2021/12/16
Ambeed
Product number
A179326
Product name
RK-33
Purity
98+%
Packaging
5mg
Price
$139
Updated
2021/12/16
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RK-33 Chemical Properties,Usage,Production

Description

RK-33 (1070773-09-9) is an inhibitor of the RNA helicase DDX3 – IC50’s = 4.4-8.4 μM in high DDX3 expressing lung cancer cell lines A549, H1299, H23, and H460.1,2?Inhibition of DDX3 led to activation of cell death pathways, inhibition of Wnt pathway signaling, and abrogation of non-homologous end-joining (NHEJ) DNA repair. RK-33 was also active in colorectal cancer?3, prostate cancer4, and medulloblastoma cancer5?cell lines. RK-33 caused radiosensitization in breast cancer through inhibition of mitochondrial translation.6?RK-33 facilitates differentiation in human embryonic stem cells (hESC) and decreases pluripotency markers as well as reducing teratoma formation.7

Uses

RK 33 is an inhibitor of DDX3, an ATP-dependent RNA helicase (1). Aberrant regulation of DDX3 is related to various diseases such as prostate and breast cancer (2). RK 33 was shown to decrease proliferation of prostate cancer cells and induced a G1 phase cell-cycle arrest (2).

References

1) Kondaskar?et al.?(2011),?Novel, Broad Spectrum Anticancer Agents Containing the Tricyclic 5:7:5-Fused Diimidazodiazepine Ring System; ACS Med. Chem. Lett.,?2?252 2) Bol?et al.?(2015),?Targeting DDX3 with a small molecule inhibitor for lung cancer therapy; EMBO Mol. Med.,?7?648 3) Heerma van Voss?et al.?(2015),?Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer; Oncotarget,?6?28312 4) Xie?et al.?(2016),?RK-33 Radiosensitizes Prostate Cancer Cells by Blocking the RNA Helicase DDX3; Cancer Res.,?76?6340 5) Tantravedi?et al.?(2019),?Targeting DDX3 in Medulloblastoma Using the Small Molecule Inhibitor RK-33; Transl. Oncol.,?12?96 6) Heerma van Voss?et al.?(2018),?Targeting mitochondrial translation by inhibiting DDX3: a novel radiosensitization strategy for cancer treatment;?Oncogene,?37?63 7) Kerr?et al.?(2019),?Targeting RNA helicase DDX3 in stem cell maintenance and teratoma formation; Genes Cancer,?10?11

RK-33 Preparation Products And Raw materials

Raw materials

Preparation Products

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RK-33 Suppliers

China 73 United States 9 USA 1 Global 83
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
United States Biological
Tel
--
Fax
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Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
ApexBio Technology
Tel
--
Fax
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Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Focus Biomolecules
Tel
--
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Email
sales@focusbiomolecules.com
Country
United States
ProdList
1284
Advantage
58
United States Biological
Tel
--
Fax
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Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81
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View Lastest Price from RK-33 manufacturers

Career Henan Chemical Co
Product
RK-33 1070773-09-9
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-23

1070773-09-9, RK-33Related Search:

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  • 3,7-Bis(4-methoxybenzyl)-3,7-dihydro-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one
  • 3,7-Bis(4-methoxybenzyl)-3,7-dihydro-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one[RK33
  • 3,7-Bis(4-methoxybenzyl)-3,7-dihydro-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one
  • 1070773-09-9