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(2S)-Octyl-α-hydroxyglutarate

Product Name
(2S)-Octyl-α-hydroxyglutarate
CAS No.
1391194-64-1
Chemical Name
(2S)-Octyl-α-hydroxyglutarate
Synonyms
Octyl-(S)-2HG;(2S)-Octyl-2-HG;(2S)-Octyl-a-hydroxyglutarate;(2S)-Octyl-α-hydroxyglutarate;(2S)-Octyl-.alpha.-hydroxyglutarate;(S)-2-Hydroxy-pentanedioic acid 1-octyl ester;(2S)-2-Hydroxy-pentanedioic acid 1-octyl ester;(S)-4-Hydroxy-5-(octyloxy)-5-oxopentanoic acid;Pentanedioic acid, 2-hydroxy-, 1-octyl ester, (2S)-
CBNumber
CB13152419
Molecular Formula
C13H24O5
Formula Weight
260.32666
MOL File
1391194-64-1.mol
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(2S)-Octyl-α-hydroxyglutarate Property

Melting point:
137 - 139o C
Boiling point:
420.5±35.0 °C(Predicted)
Density 
1.088±0.06 g/cm3(Predicted)
storage temp. 
Hygroscopic, Refrigerator, Under inert atmosphere
solubility 
Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly)
pka
4.45±0.10(Predicted)
form 
Solid
color 
White to Pale Yellow
Stability:
Hygroscopic
InChI
1S/C13H24O5/c1-2-3-4-5-6-7-10-18-13(17)11(14)8-9-12(15)16/h11,14H,2-10H2,1H3,(H,15,16)/t11-/m0/s1
InChIKey
UJZOKTKSGUOCCM-NSHDSACASA-N
SMILES
O[C@@H](CCC(=O)O)C(=O)OCCCCCCCC
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16367
Product name
(2S)-Octyl-α-hydroxyglutarate
Purity
≥95%
Packaging
1mg
Price
$54
Updated
2024/03/01
Cayman Chemical
Product number
16367
Product name
(2S)-Octyl-α-hydroxyglutarate
Purity
≥95%
Packaging
5mg
Price
$231
Updated
2024/03/01
Cayman Chemical
Product number
16367
Product name
(2S)-Octyl-α-hydroxyglutarate
Purity
≥95%
Packaging
10mg
Price
$410
Updated
2024/03/01
TRC
Product number
O287610
Product name
(2S)-Octyl-α-hydroxyglutarate
Packaging
10mg
Price
$360
Updated
2021/12/16
TRC
Product number
O287610
Product name
(2S)-Octyl-α-hydroxyglutarate
Packaging
25mg
Price
$860
Updated
2021/12/16
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(2S)-Octyl-α-hydroxyglutarate Chemical Properties,Usage,Production

Uses

(2S)-Octyl-α-hydroxyglutarate is a cell permeable derivative of the L-isomer of 2-Hydroxyglutaric Acid (H942575), a potential inhibitor of glutamate carboxypeptidase. Also, being structurally similar to α-ketoglutarate, it competitively inhibits α-ketoglutarate dependent dioxygenases.

Biological Activity

Octyl-(S)-2HG (Octyl-L-2HG) is a membrane-permeant precursor form of the oncometabolite L-2-hydroxyglutarate (L2HG) produced from α‐KG by malate dehydrogenases (MDH1/2) and lactate dehydrogenase (LDHA). L2HG can be converted back to α-KG by L-2-hydroxyglutarate dehydrogenase (LHGDH), deletion or mutations of which lead to L2HG accumulation, metabolic disorders and reduced 5hmC levels. Both D- and L-2HG inhibit Jumonji histone demethylases and Tet oxygenases by competing against α-KG binding. However, L2HG is an antagonist, while R2HG (D2HG) is an agonist of α-KG-dependent prolylhydroxylase (EglN).

(2S)-Octyl-α-hydroxyglutarate Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S)-Octyl-α-hydroxyglutarate Suppliers

CHINA 28 India 1 United States 2 Global 31
JW & Y Pharmlab Co., Ltd.
Tel
021-64340559 13651849907;
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021- 64345308
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xinyu_shi@jwypharmlab.com.cn
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China
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11999
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Shanghai Carlow Chemicals Co., Ltd.
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21-33526724 18930996265
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+86 21 37023730
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info@carlowchem.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
Email
info@efebio.com
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China
ProdList
9803
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Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
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19103
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
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United States
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32467
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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11218
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Shanghai hongqu biomedical technology co. LTD
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88888888888
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hongquchem@qq.com
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China
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Energy Chemical
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021-58432009 400-005-6266
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021-58436166
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marketing1@energy-chemical.com
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China
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Kaifeng Mingren Pharmaceutical Co.,LTD
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0371-65741762
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China
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TargetMol Chemicals Inc.
Tel
4008200310
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marketing@tsbiochem.com
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China
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1391194-64-1, (2S)-Octyl-α-hydroxyglutarateRelated Search:


  • (2S)-Octyl-α-hydroxyglutarate
  • (S)-2-Hydroxy-pentanedioic acid 1-octyl ester
  • (2S)-2-Hydroxy-pentanedioic acid 1-octyl ester
  • (2S)-Octyl-.alpha.-hydroxyglutarate
  • (2S)-Octyl-2-HG
  • (2S)-Octyl-a-hydroxyglutarate
  • Pentanedioic acid, 2-hydroxy-, 1-octyl ester, (2S)-
  • Octyl-(S)-2HG
  • (S)-4-Hydroxy-5-(octyloxy)-5-oxopentanoic acid
  • 1391194-64-1