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IOX4

Product Name
IOX4
CAS No.
1154097-71-8
Chemical Name
IOX4
Synonyms
IOX4;IOX4 NEW;IOX4; IOX-4; IOX 4;PHD2 inhibitor IOX4;t-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate;tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate;IOX 4,HIF-PH,HIFs,Hypoxia-inducible factors,IOX4,IOX-4,inhibit,HIF/HIF Prolyl-Hydroxylase,Inhibitor;3-Pyridinecarboxylic acid, 6-[2,5-dihydro-5-oxo-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl]-, 1,1-dimethylethyl ester
CBNumber
CB13152631
Molecular Formula
C15H16N6O3
Formula Weight
328.33
MOL File
1154097-71-8.mol
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IOX4 Property

Melting point:
>190° (dec.)
Boiling point:
502.2±60.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator, Under inert atmosphere
solubility 
DMSO (Sparingly, Sonicated), Methanol (Slightly, Sonicated)
form 
Solid
pka
1.36±0.29(Predicted)
color 
Light Beige to Beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18181
Product name
IOX4
Purity
≥98%
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
18181
Product name
IOX4
Purity
≥98%
Packaging
10mg
Price
$138
Updated
2024/03/01
Cayman Chemical
Product number
18181
Product name
IOX4
Purity
≥98%
Packaging
25mg
Price
$324
Updated
2024/03/01
Cayman Chemical
Product number
18181
Product name
IOX4
Purity
≥98%
Packaging
50mg
Price
$575
Updated
2024/03/01
TRC
Product number
I737010
Product name
IOX4
Packaging
250mg
Price
$1440
Updated
2021/12/16
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IOX4 Chemical Properties,Usage,Production

Description

IOX4 is a potent inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; IC50 = 1.6 nM). It displays >1,000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases, including JMJD isoforms, FBXL11, JARID1C, BBOX1, FIH, and FTO. IOX4 is active in vivo, inhibiting prolyl hydroxylation and increasing HIF-1α levels in cells (IC50 values range from 5.6 to 11.7 μM) and inducing HIF-1α and HIF-2α expression in mice. The induction of HIF expression in mice occurs in the brain as well as in the liver, kidney, and heart, indicating that IOX4 penetrates the blood-brain barrier.

Uses

IOX4 is a triazole based potent and selective inhibitor of hypoxia-inducible factor (HIF) prolyl-hydroxylase. It induces HIFα in cells of mouse brain. It is useful for studies that aim to validate the upregulation of HIF for treatment of cerebral diseases such as stroke.

IOX4 Preparation Products And Raw materials

Raw materials

Preparation Products

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IOX4 Suppliers

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1154097-71-8, IOX4Related Search:


  • IOX4
  • tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate
  • 3-Pyridinecarboxylic acid, 6-[2,5-dihydro-5-oxo-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl]-, 1,1-dimethylethyl ester
  • t-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate
  • IOX4; IOX-4; IOX 4
  • PHD2 inhibitor IOX4
  • IOX4 NEW
  • IOX 4,HIF-PH,HIFs,Hypoxia-inducible factors,IOX4,IOX-4,inhibit,HIF/HIF Prolyl-Hydroxylase,Inhibitor
  • 1154097-71-8