L-Leucyl-L-Leucine methyl ester (hydrochloride)

Product Name: L-Leucyl-L-Leucine methyl ester (hydrochloride)
CAS No.: 6491-83-4
Chemical Name: L-Leucyl-L-Leucine methyl ester (hydrochloride)
Synonyms: Leu-Leu-ome hydrochloride;H-Leu-leu-OMe hydrochloride;L-Leucyl-L-Leucine methyl ester;L-Leucyl-L-Leucine methyl ester (hydrochloride);L-Leucine, L-leucyl-, methyl ester, monohydrochloride;L-Leucyl-L-Leucine methyl ester hydrochloride, 10 mM in DMSO;methyl (2S)-2-[(2S)-2-amino-4-methylpentanamido]-4-methylpentanoate hydrochloride;lymphocytes,leukocytes,monocytes,pathway,LLeucylLLeucine methyl ester hydrochloride,LLOMe,inhibit,polymorphonuclear,stress,Leu-Leu methyl ester,cytotoxic,Inhibitor,L Leucyl L Leucine methyl ester hydrochloride,Endogenous Metabolite,endolysosomal
CBNumber: CB13152666
Molecular Formula: C13H27ClN2O3
Formula Weight: 294.81808
MOL File: 6491-83-4.mol

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L-Leucyl-L-Leucine methyl ester (hydrochloride) Property

Melting point:: 177-181°C
storage temp.: Hygroscopic, Refrigerator, under inert atmosphere
solubility: DMSO (Slightly), Water (Slightly)
form: Solid
color: White to Off-White
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16008
Product name: L-Leucyl-L-Leucine methyl ester (hydrochloride)
Purity: ≥95%
Packaging: 100mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16008
Product name: L-Leucyl-L-Leucine methyl ester (hydrochloride)
Purity: ≥95%
Packaging: 1g
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 16008
Product name: L-Leucyl-L-Leucine methyl ester (hydrochloride)
Purity: ≥95%
Packaging: 250mg
Price: $53
Updated: 2024/03/01

TRC

Product number: L330805
Product name: H-Leu-leu-OMehydrochloride
Packaging: 1g
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: 0116CW
Product name: Methylleucylleucinatehydrochloride
Packaging: 100mg
Price: $133
Updated: 2021/12/16

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L-Leucyl-L-Leucine methyl ester (hydrochloride) Chemical Properties,Usage,Production

Description

L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4⁺ and CD8⁺ T lymphocytes without affecting helper T cells and B cells. It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells. Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells.

Uses

H-Leu-leu-OMe HCl

References

[1] M OHLIN. The effect of leucyl-leucine methyl ester on proliferation and Ig secretion of EBV-transformed human B lymphocytes.[J]. Immunology, 1989, 66 4: 485-490.
[2] D L THIELE P E L. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1990, 87 1: 83-87. DOI: 10.1073/pnas.87.1.83

L-Leucyl-L-Leucine methyl ester (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Leucyl-L-Leucine methyl ester (hydrochloride) Suppliers

China 56 India 1 United States 7 Global 64

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6491-83-4, L-Leucyl-L-Leucine methyl ester (hydrochloride)Related Search:

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L-Leucyl-L-Leucine methyl ester (hydrochloride)

methyl (2S)-2-[(2S)-2-amino-4-methylpentanamido]-4-methylpentanoate hydrochloride

Leu-Leu-ome hydrochloride

H-Leu-leu-OMe hydrochloride

L-Leucine, L-leucyl-, methyl ester, monohydrochloride

L-Leucyl-L-Leucine methyl ester

lymphocytes,leukocytes,monocytes,pathway,LLeucylLLeucine methyl ester hydrochloride,LLOMe,inhibit,polymorphonuclear,stress,Leu-Leu methyl ester,cytotoxic,Inhibitor,L Leucyl L Leucine methyl ester hydrochloride,Endogenous Metabolite,endolysosomal

L-Leucyl-L-Leucine methyl ester hydrochloride, 10 mM in DMSO

6491-83-4

C13H26N2O3ClH