3-FORMYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
- Product Name
- 3-FORMYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 833474-06-9
- Chemical Name
- 3-FORMYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- 4-Boc-3-formyl-morpholine;N-Boc-3-morpholinecarbaldehyde;4-Boc-3-morpholinecarbaldehyde;3-FORMYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER;(S)-3-Formyl-morpholine-4-carboxylicacidtert-butylester;4-Morpholinecarboxylic acid, 3-formyl-, 1,1-dimethylethyl ester
- CBNumber
- CB1315471
- Molecular Formula
- C10H17NO4
- Formula Weight
- 215.25
- MOL File
- 833474-06-9.mol
3-FORMYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER Property
- Boiling point:
- 309.0±42.0 °C(Predicted)
- Density
- 1.180±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- -3.28±0.40(Predicted)
- Appearance
- White to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B814835
- Product name
- tert-butyl3-formylmorpholine-4-carboxylate
- Packaging
- 100mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- CHM0238014
- Product name
- TERT-BUTYL-3-FORMYLMORPHOLINE-4-CARBOXYLATE
- Purity
- 98.00%
- Packaging
- 0.25G
- Price
- $1243
- Updated
- 2021/12/16
- Product number
- CHM0238014
- Product name
- TERT-BUTYL-3-FORMYLMORPHOLINE-4-CARBOXYLATE
- Purity
- 98.00%
- Packaging
- 100G
- Price
- $3249.02
- Updated
- 2021/12/16
- Product number
- 53R0080
- Product name
- 3-Formyl-morpholine-4-carboxylicacidtert-butylester
- Purity
- 97%
- Packaging
- 100mg
- Price
- $137
- Updated
- 2021/12/16
- Product number
- MP-0287
- Product name
- 4-Boc-3-formyl-morpholine
- Purity
- 97%
- Packaging
- 0.25g
- Price
- $225.87
- Updated
- 2021/12/16
3-FORMYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Uses
(S)-3-Formyl-morpholine-4-carboxylic Acid tert-Butyl Ester is used in preparation of dihydrobenzodioxine derivatives and analogs as RAS-effector protein interaction inhibitors.
Synthesis
473923-56-7
833474-06-9
General procedure for the synthesis of 4-BOC-3-morpholinecarboxaldehyde from tert-butyl 3-(hydroxymethyl)morpholine-4-carboxylate: to a stirred solution of oxalyl chloride (3.73 g, 2.56 mL, 29.00 mmol) in dichloromethane (DCM, 80 mL) was slowly added at -78 °C dimethyl sulfoxide (DMSO, 4.93 g, 4.47 mL, and 63.00 mmol). after 15 min, a solution of intermediate 90 (5.70 g, 26.26 mmol) in DCM (50 mL) was added. The reaction mixture was continued to be stirred at -78 °C for 2 hours. Subsequently, triethylamine (NEt3, 13.12 g, 18.71 mL, 129.70 mmol) was added and the reaction mixture was stirred at -78 °C for 30 min, then slowly warmed to room temperature and stirring was continued for 1 hour. After completion of the reaction, the mixture was concentrated in vacuum and the residue was partitioned between water (200 mL) and ethyl acetate (EtOAc, 200 mL). The aqueous phase was extracted with EtOAc (2 x 200 mL), and the combined organic phases were washed with brine (300 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered, and the solvent removed in vacuum to afford 4-BOC-3-morpholinecarboxaldehyde (4.80 g, 84% yield) as a pale yellow crude solid. Nuclear magnetic resonance hydrogen spectroscopy (1H NMR, CDCl3) data: δ 9.58 (1H, s), 4.31 (2H, m), 3.62 (2H, br.m), 3.41 (1H, br.m), 3.11 (1H, br.s), 2.93 (1H, br.m), 1.40 (9H, s).
References
[1] Patent: WO2006/114606, 2006, A1. Location in patent: Page/Page column 70
[2] Patent: US2006/46984, 2006, A1. Location in patent: Page/Page column 26
[3] Patent: US2010/261701, 2010, A1. Location in patent: Page/Page column 144
[4] Patent: WO2006/99352, 2006, A1. Location in patent: Page/Page column 36
3-FORMYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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