ChemicalBook > CAS DataBase List > Acebilustat
Acebilustat
Description References- Product Name
- Acebilustat
- CAS No.
- 943764-99-6
- Chemical Name
- Acebilustat
- Synonyms
- ZK-322;ZK 322;CS-2501;EP-501);CTX-4430;Acebilustat;ZK 322;ZK-322;Acebilustat(ZK322);Acebilustat,CTX-4430;Acebilustat USP/EP/BP
- CBNumber
- CB13155056
- Molecular Formula
- C29H27N3O4
- Formula Weight
- 481.54
- MOL File
- 943764-99-6.mol
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Acebilustat Property
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform: slightly soluble; DMSO: slightly soluble; Methanol: slightly soluble
- form
- A crystalline solid
- color
- White to off-white
- CAS DataBase Reference
- 943764-99-6
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N-Bromosuccinimide Price
Ambeed
- Product number
- A639379
- Product name
- Acebilustat
- Purity
- 99%
- Packaging
- 5mg
- Price
- $373
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC9986
- Product name
- Acebilustat(ZK322)
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1200
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC9986
- Product name
- Acebilustat(ZK322)
- Purity
- >98%
- Packaging
- 1g
- Price
- $2500
- Updated
- 2021/12/16
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Acebilustat Chemical Properties,Usage,Production
Description
Acebilustat (also known as CTX-4430) is a new once-daily oral anti-inflammatory drug in development for treatment of cystic fibrosis (CF) and other diseases. It is an inhibitor of leukotriene A4 hydrolase, which is responsible for the production of leukotriene B4 (LTB4). The later is a molecule that leads to inflammation. Therefore, Acebilustat can treat inflammation through suppressing the production of leukotriene B4.
References
https://www.cff.org/Trials/Pipeline/details/108/CTX-4430
Springman, E., et al. "127 Pharmacokinetic and pharmacodynamic profile of CTX-4430 in two phase 1 studies." Journal of Cystic Fibrosis14(2015):S90-S90.
Springman, E., et al. "126 A phase 1 clinical study of CTX-4430 in cystic fibrosis patients." Journal of Cystic Fibrosis 14(2015):S90-S90.
Elborn, J. S., et al. "Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction." Clinical & Translational Science 10.1(2017):20-27.
Uses
Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory agent.
References
[1] Elborn JS, et al. Phase 1 Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis. Clin Transl Sci. 2016 Nov 2 DOI:10.1111/cts.12428
[2] Elborn JS, et al. Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction. Clin Transl Sci. 2016 Oct 28. DOI:10.1111/cts.12426
Acebilustat Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Acebilustat manufacturers
Shaanxi Xianhe Biotech Co., Ltd
- Product
- Acebilustat 943764-99-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000kg
- Release date
- 2025-04-30
Hebei Yanxi Chemical Co., Ltd.
- Product
- Acebilustat 943764-99-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-16
Dideu Industries Group Limited
- Product
- Acebilustat 943764-99-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-17