Description References
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Acebilustat

Description References
Product Name
Acebilustat
CAS No.
943764-99-6
Chemical Name
Acebilustat
Synonyms
ZK-322;ZK 322;CS-2501;CTX-4430;Acebilustat;ZK 322;ZK-322;Acebilustat(ZK322);Acebilustat,CTX-4430;Acebilustat USP/EP/BP;Acebilustat, 10 mM in DMSO
CBNumber
CB13155056
Molecular Formula
C29H27N3O4
Formula Weight
481.54
MOL File
943764-99-6.mol
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Acebilustat Property

storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Chloroform: slightly soluble; DMSO: slightly soluble; Methanol: slightly soluble
form 
A crystalline solid
color 
White to off-white
CAS DataBase Reference
943764-99-6
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Ambeed
Product number
A639379
Product name
Acebilustat
Purity
99%
Packaging
5mg
Price
$373
Updated
2021/12/16
DC Chemicals
Product number
DC9986
Product name
Acebilustat(ZK322)
Purity
>98%
Packaging
250mg
Price
$1200
Updated
2021/12/16
DC Chemicals
Product number
DC9986
Product name
Acebilustat(ZK322)
Purity
>98%
Packaging
1g
Price
$2500
Updated
2021/12/16
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Acebilustat Chemical Properties,Usage,Production

Description

Acebilustat (also known as CTX-4430) is a new once-daily oral anti-inflammatory drug in development for treatment of cystic fibrosis (CF) and other diseases. It is an inhibitor of leukotriene A4 hydrolase, which is responsible for the production of leukotriene B4 (LTB4). The later is a molecule that leads to inflammation. Therefore, Acebilustat can treat inflammation through suppressing the production of leukotriene B4. 

References

https://www.cff.org/Trials/Pipeline/details/108/CTX-4430
Springman, E., et al. "127 Pharmacokinetic and pharmacodynamic profile of CTX-4430 in two phase 1 studies." Journal of Cystic Fibrosis14(2015):S90-S90.
Springman, E., et al. "126 A phase 1 clinical study of CTX-4430 in cystic fibrosis patients." Journal of Cystic Fibrosis 14(2015):S90-S90.
Elborn, J. S., et al. "Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction." Clinical & Translational Science 10.1(2017):20-27.

Acebilustat Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Acebilustat manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Acebilustat 943764-99-6
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-16
Dideu Industries Group Limited
Product
Acebilustat 943764-99-6
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-17

943764-99-6, AcebilustatRelated Search:

Montelukast sodium Roflumilast XMD16-5 GNE-3511 BAY-876 RAF709

  • ZK 322
  • ZK 322;ZK-322
  • ZK-322
  • CS-2501
  • Acebilustat(ZK322)
  • Acebilustat
  • CTX-4430
  • Benzoic acid, 4-[[(1S,4S)-5-[[4-[4-(2-oxazolyl)phenoxy]phenyl]methyl]-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]-
  • Acebilustat USP/EP/BP
  • Acebilustat,Aminopeptidase,Inhibitor,inhibit,CTX 4430,CTX4430
  • 4-(((1S,4S)-5-(4-(4-(Oxazol-2-yl)phenoxy)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)benzoic acid
  • Acebilustat,CTX-4430
  • Acebilustat, 10 mM in DMSO
  • 943764-99-6