Ibrutinib-biotin

Product Name: Ibrutinib-biotin
CAS No.: 1599432-18-4
Chemical Name: Ibrutinib-biotin
Synonyms: Ibrutinib-biotin;Ibrutinib-biotin-1;Reaxys ID: 26833452;N1-(4-(((E)-4-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-4-oxobut-2-en-1-yl)(methyl)amino)butyl)-N5-(15-oxo-19-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-14-azanonadecyl)glutaramide;Pentanediamide, N1-[4-[[4-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-4-oxo-2-buten-1-yl]methylamino]butyl]-N5-[19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-4,7,10-trioxa-14-azanonadec-1-yl]-
CBNumber: CB13155061
Molecular Formula: C56H80N12O9S
Formula Weight: 1097.3744
MOL File: 1599432-18-4.mol

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Ibrutinib-biotin Property

Boiling point:: 1288.9±65.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 50 mg/mL (45.56 mM)
form: Solid
pka: 13.90±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6019
Product name: Ibrutinib-biotin
Purity: 99.09%
Packaging: 5mg
Price: $900
Updated: 2021/12/16

AK Scientific

Product number: 2051AQ
Product name: Ibrutinib-biotin-1
Packaging: 5mg
Price: $1264.4
Updated: 2021/12/16

ChemScene

Product number: CS-6019
Product name: Ibrutinib-biotin
Purity: 99.09%
Packaging: 10mg
Price: $1320
Updated: 2021/12/16

ChemScene

Product number: CS-6019
Product name: Ibrutinib-biotin
Purity: 99.09%
Packaging: 50mg
Price: $4800
Updated: 2021/12/16

CSNpharm

Product number: CSN19154
Product name: Ibrutinib-biotin
Packaging: 25mg
Price: $2021
Updated: 2021/12/16

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Ibrutinib-biotin Chemical Properties,Usage,Production

Biological Activity

Ibrutinib-biotin is a probe composed of Ibrutinib linked to biotin through a long chain linker. For details, please refer to Compound 1-5 in WO2014059368A1. It inhibits BTK with an IC50 value of 0.755-1.02 nM.

in vitro

Ibrutinib-biotin (Compound 1-5) is a probe that consists of Ibrutinib linked to biotin via a long chain linker. Ibrutinib is a TEC family kinase inhibitor. The TEC kinase family is composed of five members, TEC , BTK (Bruton's Tyrosine Kinase), ITK (interleukin-2-inducible T-cell kinase)/EMT/TSK, BMX and TXK/RLK. The TEC family kinases participate in phosphotyrosine-mediated and phospholipid-mediated signaling systems. Many TEC family proteins are abundantly expressed in hematopoietic tissues, and play important roles in the growth and differentiation processes of blood cells.

target

IC50: 0.755-1.02 nM (BTK), 1.71-2.29 nM (TEC), 3.66-4.27 nM (BLK), 4.42-5.57 nM (BMX), 5.99-6.92 nM (LCK), 33.8- 36.3 nM (Src), 0.187-0.198 μM (ITK), 5.34-4.87 μM (JAK3)

Ibrutinib-biotin Preparation Products And Raw materials

Raw materials

Preparation Products

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Ibrutinib-biotin Suppliers

China 14 India 2 United States 4 Global 20

Musechem

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1599432-18-4, Ibrutinib-biotinRelated Search:

D18 Ibrutinib

Ibrutinib-biotin

Ibrutinib-biotin-1

Reaxys ID: 26833452

Pentanediamide, N1-[4-[[4-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-4-oxo-2-buten-1-yl]methylamino]butyl]-N5-[19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-4,7,10-trioxa-14-azanonadec-1-yl]-

N1-(4-(((E)-4-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-4-oxobut-2-en-1-yl)(methyl)amino)butyl)-N5-(15-oxo-19-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-14-azanonadecyl)glutaramide

1599432-18-4

C56H80N12O9S