Vibegron

Product Name: Vibegron
CAS No.: 1190389-15-1
Chemical Name: Vibegron
Synonyms: Vibegron;RVT-901;KRP-114V;Vibegron (MK-4618);(6S)-4,6,7,8-Tetrahydro-N-[4-[[(2S,5R)-5-[(R)-hydroxyphenylmethyl]-2-pyrrolidinyl]methyl]phenyl]-4-oxopyrrolo[1,2-a]pyrimidine-6-carboxamide;Pyrrolo[1,2-a]pyrimidine-6-carboxamide, 4,6,7,8-tetrahydro-N-[4-[[(2S,5R)-5-[(R)-hydroxyphenylmethyl]-2-pyrrolidinyl]methyl]phenyl]-4-oxo-, (6S)-;13C5]-Vibegron;Vibegron-13C-D4;Vibegron，MK-4618，KRP-114V;Nadolol Impurity 6 Hydrochloride
CBNumber: CB13159928
Molecular Formula: C26H28N4O3
Formula Weight: 444.53
MOL File: 1190389-15-1.mol

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Vibegron Property

Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: 4°C, away from moisture and light
pka: 13.55±0.70(Predicted)
form: Solid
color: White to off-white
InChIKey: DJXRIQMCROIRCZ-XOEOCAAJSA-N
SMILES: C12CC[C@@H](C(NC3=CC=C(C[C@@H]4CC[C@H]([C@H](O)C5=CC=CC=C5)N4)C=C3)=O)N1C(=O)C=CN=2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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Vibegron Chemical Properties,Usage,Production

Uses

Vibegron is a potent and selective β3 Adrenergic receptor agonist for the treatment of overactive bladder.

Definition

ChEBI: Vibegron is a pyrrolopyrimidine obtained by formal condensation of the carboxy group of (6S)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylic acid with the amino group of (R)-[(2R,5S)-5-(4-aminobenzyl)pyrrolidin-2-yl](phenyl)methanol. It is a beta3-adrenergic receptor agonist currently in clinical development for the treatment of patients with overactive bladder. It has a role as a beta-adrenergic agonist. It is a secondary alcohol, a member of pyrrolidines, a member of benzenes, a secondary carboxamide, a pyrrolopyrimidine and a secondary amine.

in vivo

Vibegron (1~12 μΜ; i.v.) exhibits dose dependent decreases in micturition pressure and increases in functional bladder capacity^[3].
Vibegron (30 mg/kg; p.o.; 4 weeks) upregulates mRNA levels of type 1, type 3 collagen, TGF‐β1, and HIF‐1α^[4].
Vibegron (1 and 10 mg/kg; i.v.; interval 30 minutes) (10 mg/kg) in oxo-M-treated rats makes bladder capacity significantly decreased compared with oxo-M-not treated rats (intravesical instillation of vehicle)^[5].

Animal Model:	Rat
Dosage:	1~12 μΜ
Administration:	I.v.
Result:	Exhibited dose dependent decreases in micturition pressure and increases in functional bladder capacity.

Animal Model:	Female C57BL/6N mice (9 weeks old)
Dosage:	30 mg/kg
Administration:	P.o.; 4 weeks
Result:	Upregulated mRNA levels of type 1, type 3 collagen, TGF‐β1, and HIF‐1α at 4 weeks.

Animal Model:	Female F344 rats (120–160 g)
Dosage:	1 and 10 mg/kg
Administration:	I.v.; Interval 30 minutes
Result:	Vibegron (10 mg/kg) in oxo-M-treated rats made bladder capacity significantly decreased compared with oxo-M-not treated rats (intravesical instillation of vehicle).

IC 50

β adrenergic receptor; β3 adrenoceptor: 1.1 nM (EC₅₀)

Vibegron Preparation Products And Raw materials

Raw materials

Preparation Products

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Vibegron Suppliers

China 108 India 2 United States 4 Global 114

Nanjing Vcare PharmaTech Co., Ltd

Tel: 025-58741518 13327700685
Email: sales@vcarepharmatech.com
Country: China
ProdList: 487
Advantage: 58

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 8555
Advantage: 58

Cangzhou Kangrui Medical Technology Co., LTD

Tel: 18632776803
Email: cangzhoukangrui@126.com;355803330@qq.com
Country: China
ProdList: 640
Advantage: 58

Cangzhou Enke Pharma Tech Co.,ltd.

Tel: 0317-5106596 15533709196
Email: 1154424302@qq.com
Country: China
ProdList: 2315
Advantage: 58

CHANGZHOU PHARMACEUTICAL FACTORY

Tel: 519-88821493 18915891730
Email: shm@czpharma.com
Country: China
ProdList: 170
Advantage: 58

Valiant Co., Ltd.

Tel: 0535-6101880
Fax: 0535-6386989
Email: liutao@valiant-cn.com
Country: China
ProdList: 286
Advantage: 60

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

Cangzhou Enke Pharma-tech Co., Ltd.

Tel: 0317-5296180 15533709196
Email: enkepharma@126.com;sale@enkepharma.com
Country: China
ProdList: 2335
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 17771478861
Email: 1936564059@qq.com
Country: China
ProdList: 1924
Advantage: 55

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View Lastest Price from Vibegron manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: MB-07133 1190389-15-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-07

Hebei Yanxi Chemical Co., Ltd.

Product: vibegron 1190389-15-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-10

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Vibegron 1190389-15-1
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-07-24

1190389-15-1, VibegronRelated Search:

(6S)-4,6,7,8-Tetrahydro-N-[4-[[(2S,5R)-5-[(R)-hydroxyphenylmethyl]-2-pyrrolidinyl]methyl]phenyl]-4-oxopyrrolo[1,2-a]pyrimidine-6-carboxamide

KRP-114V

RVT-901

Pyrrolo[1,2-a]pyrimidine-6-carboxamide, 4,6,7,8-tetrahydro-N-[4-[[(2S,5R)-5-[(R)-hydroxyphenylmethyl]-2-pyrrolidinyl]methyl]phenyl]-4-oxo-, (6S)-

Vibegron (MK-4618)

Vibegron-13C-D4

Vibegron，MK-4618，KRP-114V

(S)-N-(4-(((2S,5R)-5-((R)-hydroxy(phenyl)methyl)pyrrolidin-2-yl)methyl)phenyl)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxamide

13C5]-Vibegron

Nadolol Impurity 6 Hydrochloride

Vibegron

1190389-15-1

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