Motolimod
- Product Name
- Motolimod
- CAS No.
- 172377-52-5
- Chemical Name
- Motolimod
- Synonyms
- J-995;E2MATE;PGL-2001;ES-J 995;ZK-190628;BLE 00084;Estradiol Sulfamate;Estradiol 3-sulfamate;E2MATE|||BLE 00084|||ES-J 995;Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-sulfamate
- CBNumber
- CB13159933
- Molecular Formula
- C18H25NO4S
- Formula Weight
- 351.46
- MOL File
- 172377-52-5.mol
Motolimod Property
- Melting point:
- 202-204 °C(Solv: methanol (67-56-1))
- Boiling point:
- 531.1±60.0 °C(Predicted)
- Density
- 1.319±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 62.5 mg/mL (177.83 mM)
- pka
- 8.88±0.70(Predicted)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H351Suspected of causing cancer
H360May damage fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
Motolimod Chemical Properties,Usage,Production
Uses
Estradiol 3-sulfamate (BLE 00084; E2MATE; ES-J 995) is a potent, long-acting, and orally active steroid sulfatase inhibitor; inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM.
in vivo
Estradiol 3-sulfamate is readily transformed and absorbed in the gut into its oxidative metabolite, EMATE, and both compounds have already been shown to be potent, long-acting, and orally active STS inhibitors[2].
References
[1] Numazawa M, et al. Inhibition of estrone sulfatase by aromatase inhibitor-based estrogen 3-sulfamates. Steroids. 2006 May;71(5):371-9. DOI:10.1016/j.steroids.2005.12.004
[2] Pohl O, et al. Synergistic effects of E2MATE and norethindrone acetate on steroid sulfatase inhibition: a randomized phase I proof-of-principle clinical study in women of reproductive age. Reprod Sci. 2014 Oct;21(10):1256-65. DOI:10.1177/1933719114522526
Motolimod Preparation Products And Raw materials
Raw materials
Preparation Products
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