1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate

Product Name: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate
CAS No.: 477781-69-4
Chemical Name: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate
Synonyms: Benzyl-PEG4-MS;CAS_477781-69-4;MsO-(CH2CH2O)4-Bn;1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate;3,6,9,12-Tetraoxatridecan-1-ol, 13-phenyl-, 1-methanesulfonate;2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethyl methanesulfonate
CBNumber: CB13161682
Molecular Formula: C16H26O7S
Formula Weight: 362.44
MOL File: 477781-69-4.mol

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1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate Property

storage temp.: Sealed in dry,Room Temperature
form: Viscous Liquid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Activate Scientific

Product number: AS45699
Product name: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate
Purity: 97%
Packaging: 250mg
Price: $257
Updated: 2021/12/16

Activate Scientific

Product number: AS45699
Product name: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate
Purity: 97%
Packaging: 1g
Price: $524
Updated: 2021/12/16

AK Scientific

Product number: 1510DB
Product name: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-ylmethanesulfonate
Packaging: 100mg
Price: $72
Updated: 2021/12/16

Activate Scientific

Product number: AS45699
Product name: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate
Purity: 97%
Packaging: 100mg
Price: $144
Updated: 2021/12/16

Alichem

Product number: 477781694
Product name: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-ylmethanesulfonate
Packaging: 250mg
Price: $166.32
Updated: 2021/12/16

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1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate Chemical Properties,Usage,Production

Uses

Benzyl-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Synthesis

86259-87-2

124-63-0

477781-69-4

1. To a stirred mixture of 1-phenyl-2,5,8,11-tetraoxatridecan-13-ol (45.1 g, 159 mmol) and triethylamine (62.2 g, 636 mmol) in dichloromethane (800 mL) at 0 °C was slowly added methanesulfonyl chloride (36.4 g, 318 mmol). 2. After addition, the reaction mixture was stirred at room temperature overnight. 3. Upon completion of the reaction, the reaction was quenched with 1N HCl (300 mL) and then extracted with ethyl acetate. 4. The organic phases were combined, dried over magnesium sulfate, concentrated to dryness, and purified by fast chromatography to afford 1-benzyloxytrioxaundecanemethanesulfonate (56.2 g, 98%) as a clear oil. 1H NMR (400MHz, CDCl3) δ 7.25-7.32 (m, 5H), 4.54 (s, 2H), 4.32-4.34 (m, 2H), 3.71-3.73 (m, 2H), 3.59-3.66 (m, 12H), 3.03 (s, 3H).

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Benzyl-PEG4-MS 477781-69-4
Price: US $0.00/g
Min. Order: 5g
Purity: >98.00%
Supply Ability: 5g
Release date: 2024-03-25

Career Henan Chemical Co

Product: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate 477781-69-4
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2019-12-25

477781-69-4, 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonateRelated Search:

2-(2-(2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethyl methanesulfonate 2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL Tosylate of Pentaethylene glycol monobenzyl ether

1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate

Benzyl-PEG4-MS

CAS_477781-69-4

3,6,9,12-Tetraoxatridecan-1-ol, 13-phenyl-, 1-methanesulfonate

MsO-(CH2CH2O)4-Bn

2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethyl methanesulfonate

477781-69-4

C16H26O7S