Methyl 8-(tert-butyl)-6-chloroimidazo[1,2-b]pyridazine-2-carboxylate

Product Name: Methyl 8-(tert-butyl)-6-chloroimidazo[1,2-b]pyridazine-2-carboxylate
CAS No.: 1690176-75-0
Chemical Name: Methyl 8-(tert-butyl)-6-chloroimidazo[1,2-b]pyridazine-2-carboxylate
Synonyms: IUN76750;PAR-2-IN-1;PAR-2 inhibitor;PAR-2-IN-1, 10 mM in DMSO;Methyl 8-(tert-butyl)-6-chloroimidazo[1,2-b]pyridazine-2-car;Methyl 8-(tert-butyl)-6-chloroimidazo[1,2-b]pyridazine-2-carboxylate;Imidazo[1,2-b]pyridazine-2-carboxylic acid, 6-chloro-8-(1,1-dimethylethyl)-, methyl ester;Inhibitor,PAR2IN1,anti-inflammatory,anticancer,PAR 2 IN 1,inhibit,PAR2,Thrombin receptors,Protease Activated Receptor (PAR)
CBNumber: CB13162104
Molecular Formula: C12H14ClN3O2
Formula Weight: 267.71
MOL File: 1690176-75-0.mol

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Methyl 8-(tert-butyl)-6-chloroimidazo[1,2-b]pyridazine-2-carboxylate Property

Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO : 83.33 mg/mL (311.27 mM; Need ultrasonic)
pka: 0.85±0.30(Predicted)
form: Solid
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0149418
Product name: PAR-2-IN-1
Purity: 99.16%
Packaging: 10mg
Price: $170
Updated: 2021/12/16

AK Scientific

Product number: 2164EF
Product name: Methyl8-(tert-butyl)-6-chloroimidazo[1,2-b]pyridazine-2-carboxylate
Packaging: 250mg
Price: $282
Updated: 2021/12/16

ChemScene

Product number: CS-0149418
Product name: PAR-2-IN-1
Purity: 99.16%
Packaging: 25mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0149418
Product name: PAR-2-IN-1
Purity: 99.16%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0149418
Product name: PAR-2-IN-1
Purity: 99.16%
Packaging: 50mg
Price: $550
Updated: 2021/12/16

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Methyl 8-(tert-butyl)-6-chloroimidazo[1,2-b]pyridazine-2-carboxylate Chemical Properties,Usage,Production

Uses

PAR-2-IN-1 is a protease-activated receptor-2 (PAR2) signaling pathway inhibitor with anti-inflammatory and anticancer effects[1].

IC 50

PAR2

References

[1] Luc J. Farmer, et al. Imidazopyridazines useful as inhibitors of the par-2 signaling pathway. WO2015048245A1.

Methyl 8-(tert-butyl)-6-chloroimidazo[1,2-b]pyridazine-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 8-(tert-butyl)-6-chloroimidazo[1,2-b]pyridazine-2-carboxylate Suppliers

China 35 India 1 United States 5 Global 41

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1690176-75-0, Methyl 8-(tert-butyl)-6-chloroimidazo[1,2-b]pyridazine-2-carboxylateRelated Search:

Methyl 8-(tert-butyl)-6-chloroimidazo[1,2-b]pyridazine-2-carboxylate

Imidazo[1,2-b]pyridazine-2-carboxylic acid, 6-chloro-8-(1,1-dimethylethyl)-, methyl ester

IUN76750

PAR-2-IN-1

PAR-2 inhibitor

Methyl 8-(tert-butyl)-6-chloroimidazo[1,2-b]pyridazine-2-car

Inhibitor,PAR2IN1,anti-inflammatory,anticancer,PAR 2 IN 1,inhibit,PAR2,Thrombin receptors,Protease Activated Receptor (PAR)

PAR-2-IN-1, 10 mM in DMSO

1690176-75-0