1-Aminoadamantane-2,2,2′,2′,2″,2″-d6
- Product Name
- 1-Aminoadamantane-2,2,2′,2′,2″,2″-d6
- CAS No.
- 1219805-53-4
- Chemical Name
- 1-Aminoadamantane-2,2,2′,2′,2″,2″-d6
- Synonyms
- D6-Amantadine;[2H6]-Amantadine;Adamantanamine-d6;(2,2,8,8,9,9-2H?)adamantan-1-amine;1-Aminoadamantane-2,2,2′,2′,2″,2″-d6;Adamantanamine-d6 Solution, 100μg/mL;Amantadine-d6 (1-Amino Adamantane-d6);Amantadine-d6 DISCONTINUED, offer A575822 / A575823;1-Aminoadamantane-2,2,2',2',2'',2''-d6 Solution in Methanol, 100μg/mL;Amantadine D6Q: What is Amantadine D6 Q: What is the CAS Number of Amantadine D6 Q: What is the storage condition of Amantadine D6 Q: What are the applications of Amantadine D6
- CBNumber
- CB13163237
- Molecular Formula
- C10H17N
- Formula Weight
- 151.25
- MOL File
- 1219805-53-4.mol
1-Aminoadamantane-2,2,2′,2′,2″,2″-d6 Property
- form
- Solid
- color
- White to off-white
1-Aminoadamantane-2,2,2′,2′,2″,2″-d6 Chemical Properties,Usage,Production
Uses
Amantadine-d6 is the deuterium labeled Amantadine[1]. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[2][3][4][5][6][7].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200. DOI:10.1007/s10156-003-0262-6
[3] Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 201278(14):1096-1099. DOI:10.1212/WNL.0b013e31824e8f0d
[4] Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan57(1-2):41-52. DOI:10.1016/s0166-3542(02)00199-7
[5] Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 2413(4):539. DOI:10.3390/v13040539
[6] Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct121(4):773-85. DOI:10.1097/ALN.0000000000000352
[7] Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 201536(3):904-910. DOI:10.3892/ijmm.2015.2289
1-Aminoadamantane-2,2,2′,2′,2″,2″-d6 Preparation Products And Raw materials
Raw materials
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