CFI-400437

Product Name: CFI-400437
CAS No.: 1247000-76-5
Chemical Name: CFI-400437
Synonyms: CS-2656;CFI-400437;CFI-400437 HCl;CFI 400437;CFI400437;(1E)-CFI-400437 2HCl;CFI-400437 dihydrochloride;(1E)-CFI-400437 dihydrochloride;5-Methoxy-3-((3-((E)-2-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)vinyl)-1H-indazol-6-yl)methylene)indolin-2-one dihydrochloride;antiproliferative,Inhibitor,Polo-like Kinase (PLK),anticancer,cells,MCF-7,(1E) CFI 400437 dihydrochloride,PLK4,inhibit,(1E)CFI400437 dihydrochloride
CBNumber: CB13167321
Molecular Formula: C29H29ClN6O2
Formula Weight: 529.04
MOL File: 1247000-76-5.mol

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CFI-400437 Property

storage temp.: 4°C, protect from light
solubility: DMSO : 12.5 mg/mL (22.10 mM; Need ultrasonic)
form: Solid
color: Brown to orange

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: SYN1207
Product name: CFI-400437
Packaging: 5mg
Price: $410
Updated: 2021/12/16

Adipogen Life Sciences

Product number: SYN-1207-M100
Product name: CFI-400437
Purity: ≥95%
Packaging: 100mg
Price: $3186
Updated: 2021/12/16

DC Chemicals

Product number: DC10069
Product name: CFI-400437
Purity: >98%
Packaging: 10mg
Price: $400
Updated: 2021/12/16

DC Chemicals

Product number: DC10069
Product name: CFI-400437
Purity: >98%
Packaging: 50mg
Price: $1100
Updated: 2021/12/16

DC Chemicals

Product number: DC10069
Product name: CFI-400437
Purity: >98%
Packaging: 100mg
Price: $1900
Updated: 2021/12/16

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CFI-400437 Chemical Properties,Usage,Production

Uses

(1E)-CFI-400437 dihydrochloride is a potent PLK4 (IC50= 0.6 nM) inhibitor and selective against other members of the PLK family (>10 μM). (1E)-CFI-400437 dihydrochloride inhibits Aurora A, Aurora B, KDR and FLT-3 with IC50s of 0.37, 0.21, 0.48, and 0.18 μM, respectively. Antiproliferative activity[1].

in vivo

(1E)-CFI-400437 (25 mg/kg; intraperitoneal injection; daily for 21 days) dihydrochloride shows effective in a mouse xenograft model of tumor growth^[1].
The plasma levels of (1E)-CFI-400437 (50 mg/kg; IP; mice) dihydrochloride shows a Cmax of 92 ng/mL and AUC of 190 ng?h/mL, respectively. The mouse plasma protein binding measurement for (1E)-CFI-400437 is 99%, i.e., unbound compound in plasma is 1%^[1].

Animal Model:	6-8 week old female CB-17 SCID mice (MDA-MB-468 mouse xenograft model)^[1]
Dosage:	25 mg/kg
Administration:	Intraperitoneal injection; daily for 21 days
Result:	Effective in a mouse xenograft model of tumor growth. In this study, (1E)-CFI-400437 is weighed and suspended in PEG400:water (30:70) and sonicated at rt for 30 min. The compound is dispensed in aliquots and stored at ?20 C° for the duration of the study, and each aliquot was thawed at room temperature before each dose.

IC 50

PLK4: 0.6 nM (IC₅₀)

References

[1] Laufer R, et al. The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents. J Med Chem. 2013;56(15):6069-6087. DOI:10.1021/jm400380m

CFI-400437 Preparation Products And Raw materials

Raw materials

Preparation Products

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CFI-400437 Suppliers

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1247000-76-5, CFI-400437Related Search:

CFI-400437

CFI 400437;CFI400437

CS-2656

CFI-400437 HCl

(1E)-CFI-400437 dihydrochloride

CFI-400437 dihydrochloride

5-Methoxy-3-((3-((E)-2-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)vinyl)-1H-indazol-6-yl)methylene)indolin-2-one dihydrochloride

antiproliferative,Inhibitor,Polo-like Kinase (PLK),anticancer,cells,MCF-7,(1E) CFI 400437 dihydrochloride,PLK4,inhibit,(1E)CFI400437 dihydrochloride

(1E)-CFI-400437 2HCl

1247000-76-5