ChemicalBook > CAS DataBase List > KDM5-IN-1

KDM5-IN-1

Product Name
KDM5-IN-1
CAS No.
1628210-26-3
Chemical Name
KDM5-IN-1
Synonyms
KDM5-IN-1;KDM5-IN-48;KDM5 inhibitor 1;KDM5-IN-1, 10 mM in DMSO;KDM5 inhibitor compound 48;KDM5 IN 1,inhibit,Histone Demethylase,Inhibitor,KDM-5-IN-1,KDM5IN1;5-(1-tert-butyl-1H-pyrazol-4-yl)-7-oxo-6-(propan-2-yl)-4H,7H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile;Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 5-[1-(1,1-dimethylethyl)-1H-pyrazol-4-yl]-4,7-dihydro-6-(1-methylethyl)-7-oxo-
CBNumber
CB13169587
Molecular Formula
C17H20N6O
Formula Weight
324.38
MOL File
1628210-26-3.mol
More
Less

KDM5-IN-1 Property

Boiling point:
527.0±60.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 30 mg/mL (92.48 mM)
form 
Solid
pka
3.10±0.10(Predicted)
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-6443
Product name
KDM5-IN-1
Purity
99.75%
Packaging
1mg
Price
$132
Updated
2021/12/16
Axon Medchem
Product number
Axon2809
Product name
KDM5inhibitorcompound48
Purity
99%
Packaging
2x5mg
Price
$253
Updated
2021/12/16
ChemScene
Product number
CS-6443
Product name
KDM5-IN-1
Purity
99.75%
Packaging
5mg
Price
$396
Updated
2021/12/16
ChemScene
Product number
CS-6443
Product name
KDM5-IN-1
Purity
99.75%
Packaging
10mg
Price
$600
Updated
2021/12/16
ChemScene
Product number
CS-6443
Product name
KDM5-IN-1
Purity
99.75%
Packaging
50mg
Price
$1800
Updated
2021/12/16
More
Less

KDM5-IN-1 Chemical Properties,Usage,Production

Uses

KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor with an IC50 of 15.1 nM.

in vivo

When dosed orally in mice at 50 mg/kg twice a day, KDM5-IN-1 shows an unbound maximal plasma concentration Cmax>15-fold over its cell EC50, thereby providing a robust chemical probe for studying KDM5 biological functions in vivo[1].

IC 50

KDM5

References

[1] Liang J, et al. Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies. Bioorg Med Chem Lett. 2016 Aug 15;26(16):4036-41. DOI:10.1016/j.bmcl.2016.06.078

KDM5-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

KDM5-IN-1 Suppliers

China 42 United States 3 USA 1 Global 46
Wuhan TCASChem Technology Co., Ltd.
Tel
027-86697669 13986148687
Fax
86-027-86697669
Email
sales@tcaschem.com
Country
China
ProdList
4100
Advantage
55
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
Hangzhou Milestone Pharmtech Co., Ltd.
Tel
0571-82896630 18969958410
Email
sales_hz@milestonepharmtech.com
Country
China
ProdList
4895
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
7999
Advantage
62
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29759
Advantage
68
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3278
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32436
Advantage
58

1628210-26-3, KDM5-IN-1Related Search:


  • KDM5-IN-1
  • KDM5 inhibitor compound 48
  • 5-(1-tert-butyl-1H-pyrazol-4-yl)-7-oxo-6-(propan-2-yl)-4H,7H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
  • KDM5-IN-48
  • KDM5 inhibitor 1
  • Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 5-[1-(1,1-dimethylethyl)-1H-pyrazol-4-yl]-4,7-dihydro-6-(1-methylethyl)-7-oxo-
  • KDM5 IN 1,inhibit,Histone Demethylase,Inhibitor,KDM-5-IN-1,KDM5IN1
  • KDM5-IN-1, 10 mM in DMSO
  • 1628210-26-3