NCB-0846

Product Name: NCB-0846
CAS No.: 1792999-26-8
Chemical Name: NCB-0846
Synonyms: CS-2514;NCB-0846;NCB-0846 ，S8392;NCB0846;NCB 0846;NCB-0846, 10 mM in DMSO;Epoxiconazolet Impurity 5;cis-4-[[2-(1H-Benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-cyclohexanol;Wnt,MAPK Kinase Kinase Kinase,NCB0846,Inhibitor,inhibit,MAP4K,NCB-0846;Cyclohexanol, 4-[[2-(1H-benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-, cis-;cis-4-((2-((1H-Benzo[d]imidazol-6-yl)amino)quinazolin-8-yl)oxy)cyclohexanol
CBNumber: CB13169592
Molecular Formula: C21H21N5O2
Formula Weight: 375.42
MOL File: 1792999-26-8.mol

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NCB-0846 Property

Boiling point:: 726.2±70.0 °C(Predicted)
Density: 1.415±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 12.87±0.30(Predicted)
color: Off-White to Light Yellow
CAS DataBase Reference: 1792999-26-8

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B197005
Product name: cis-4-[[2-(1H-Benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-cyclohexanol
Packaging: 5mg
Price: $240
Updated: 2021/12/16

ChemScene

Product number: CS-6441
Product name: NCB-0846
Purity: 99.36%
Packaging: 5mg
Price: $132
Updated: 2021/12/16

ChemScene

Product number: CS-6441
Product name: NCB-0846
Purity: 99.36%
Packaging: 25mg
Price: $474
Updated: 2021/12/16

ChemScene

Product number: CS-6441
Product name: NCB-0846
Purity: 99.36%
Packaging: 50mg
Price: $816
Updated: 2021/12/16

ChemScene

Product number: CS-6441
Product name: NCB-0846
Purity: 99.36%
Packaging: 100mg
Price: $1440
Updated: 2021/12/16

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NCB-0846 Chemical Properties,Usage,Production

Uses

cis-4-?[[2-?(1H-?Benzimidazol-?6-?ylamino)?-?8-?quinazolinyl]?oxy]?-?cyclohexanol inhibits Traf2 and Nck-interacting protein kinase (TNIK). TNIK is involved with Canonical Wnt/b-catenin signalling, which has regulatory roles in maintaining intestinal stem cells and aberration in this pathway has been implicated in colorectal carcinogenesis. TNIK is a therapeutic target.

in vivo

NCB-0846 suppresses the growth of tumors established by inoculating HCT116 cells into immunodeficient mice. The expression of Wnt-target genes (AXIN2, MYC and CCND1) in xenografts is reduced following the administration of NCB-0846. NCB-0846 induces an increase in the sub-G1 cell population. Cleavage of poly (ADP-ribose) polymerase 1 indicates the induction of apoptosis^[1].

IC 50

Wnt; TNIK: 21 nM (IC₅₀)

NCB-0846 Preparation Products And Raw materials

Raw materials

Preparation Products

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NCB-0846 Suppliers

China 79 United States 10 Global 89

Shanghai Boyle Chemical Co., Ltd.

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Shanghai Biopharmaleader Co., Ltd.

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View Lastest Price from NCB-0846 manufacturers

Career Henan Chemical Co

Product: NCB-0846 1792999-26-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-26

1792999-26-8, NCB-0846Related Search:

CS-2514

NCB0846;NCB 0846

NCB-0846

cis-4-[[2-(1H-Benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-cyclohexanol

Cyclohexanol, 4-[[2-(1H-benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-, cis-

cis-4-((2-((1H-Benzo[d]imidazol-6-yl)amino)quinazolin-8-yl)oxy)cyclohexanol

Wnt,MAPK Kinase Kinase Kinase,NCB0846,Inhibitor,inhibit,MAP4K,NCB-0846

Epoxiconazolet Impurity 5

NCB-0846, 10 mM in DMSO

NCB-0846 ，S8392

1792999-26-8