BLU-285

ChemicalBook > CAS DataBase List > BLU-285

Product Name: BLU-285
CAS No.: 1703793-34-3
Chemical Name: BLU-285
Synonyms: Avapritinib;BLU-N;CS-2474;CPD1212;BLU-285;abaprotinib;Avapritinib(BLU-285);13C,2H3]-Avapritinib;BLU-285 (Avapritinib);BLU-285;BLU 285;BLU285
CBNumber: CB13171751
Molecular Formula: C26H27FN10
Formula Weight: 498.56
MOL File: 1703793-34-3.mol

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BLU-285 Property

Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:83.11(Max Conc. mg/mL);166.7(Max Conc. mM)
form: A crystalline solid
pka: 6.96±0.10(Predicted)
color: White to light yellow
InChIKey: DWYRIWUZIJHQKQ-JKXWNSIXNA-N
SMILES: C1N(C2N=CC([C@@](N)(C3C=CC(F)=CC=3)C)=CN=2)CCN(C2C3=CC(C4C=NN(C)C=4)=CN3N=CN=2)C1 |&1:6,r|
CAS DataBase Reference: 1703793-34-3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H332Harmful if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H340May cause genetic defects

H350May cause cancer

H360May damage fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22985
Product name: BLU-285
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 22985
Product name: BLU-285
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 22985
Product name: BLU-285
Purity: ≥98%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

Cayman Chemical

Product number: 22985
Product name: BLU-285
Purity: ≥98%
Packaging: 25mg
Price: $618
Updated: 2024/03/01

ChemScene

Product number: CS-7577
Product name: Avapritinib
Purity: 99.94%
Packaging: 25mg
Price: $690
Updated: 2021/12/16

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BLU-285 Chemical Properties,Usage,Production

Description

BLU-285 is a dual inhibitor of KIT receptor and platelet-derived growth factor receptor α (PDGFRα) tyrosine kinases with activating loop mutations (IC₅₀s = 0.27 and 0.24 nM for KIT^D816V and PDGFRα^D842V, respectively). It is >150-fold selective for KIT^D816V and PDGFRα^D842V over a kinase panel at a concentration of 3 μM. BLU-285 also has activity against a panel of KIT and PDGFRα loop mutants identified in patients with gastrointestinal stromal tumors (GISTs; IC₅₀s = <100 nM). It inhibits growth of cancer cell lines containing wild-type and mutant KIT and PDGFRα, demonstrating increased potency in cell lines expressing KIT and PDGFRα with activating loop mutations. BLU-285 (0.3-30 mg/kg) reduces tumor volume in a P815 KIT^D814Y mastocytoma allograft mouse model and a GIST patient-derived mouse xenograft model in a dose-dependent manner. Formulations containing BLU-285 have been used to treat KIT- and PDGFRα-driven malignancies.

Uses

Avapritinib is a medication used for the treatment of tumors due to one specific rare mutation. Avapritinib is a potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor.

Indications

Avapritinib is approved for the treatment of adult patients with unresectable or metastatic gastrointestinal mesenchymal stromal tumour (GIST) carrying platelet-derived growth factor receptor A (PDGFRA) exon 18 mutations, including the D842V mutation, as well as adult patients with advanced systemic mastocytosis (ASM).

brand name

Ayvakit

General Description

Class: receptor tyrosine kinase; Treatment: GIST, SM; Other name: BLU-285; Elimination half-life = 32–57 h; Protein binding = 98.8%

target

Primary targets: PDGFRA, KIT

BLU-285 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BLU-285 manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Avapritinib 1703793-34-3
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 50kg/Month
Release date: 2024-06-28

Career Henan Chemical Co

Product: BLU-285 1703793-34-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-24

1703793-34-3, BLU-285Related Search:

BLU 9931 BLU-945 BLU-782 Pralsetinib

Avapritinib(BLU-285)

BLU-285

CPD1212

Avapritinib

(1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine

BLU-285 (Avapritinib)

BLU-285;BLU 285;BLU285

CS-2474

BLU-N

(S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine

Avapritinib/CPD1212/Blu285

(S)-alpha-(4-Fluorophenyl)-alpha-methyl-2-[4-[6-(1-methyl-4-pyrazolyl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl]pyrimidine-5-methanamine

5-Pyrimidinemethanamine, α-(4-fluorophenyl)-α-methyl-2-[4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl]-, (αS)-

abaprotinib

Avapritinib (Synonyms: BLU-285)

13C,2H3]-Avapritinib

1703793-34-3

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