C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE

Product Name: C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE
CAS No.: 120740-10-5
Chemical Name: C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE
Synonyms: 5-Aminomethyl-2-Bromopyridine;6-Bromo-3-pyridinemethanamine;(6-bromo-3-pyridyl)methanamine;3-Pyridinemethanamine, 6-bromo-;(6-broMopyridin-3-yl)MethanaMine;(2-Bromo-5-pyridinyl)methylamine;C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE;5-(Aminomethyl)-2-bromopyridine 95+%;C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE ISO 9001：2015 REACH
CBNumber: CB1317536
Molecular Formula: C6H7BrN2
Formula Weight: 187.04
MOL File: 120740-10-5.mol

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C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE Property

Boiling point:: 290.1±25.0 °C(Predicted)
Density: 1.574±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 7.74±0.29(Predicted)
form: solid
color: Yellow

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: A613685
Product name: 5-Aminomethyl-2-bromopyridine
Packaging: 250mg
Price: $95
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-9-0A
Product name: 5-(Aminomethyl)-2-bromopyridine
Purity: 98%
Packaging: 250mg
Price: $74
Updated: 2021/12/16

Apolloscientific

Product number: OR345226
Product name: 5-(Aminomethyl)-2-bromopyridine
Packaging: 250mg
Price: $88
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: A10387
Product name: 5-(Aminomethyl)-2-bromopyridine
Purity: 98%
Packaging: 1g
Price: $90
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-9-0A
Product name: 5-(Aminomethyl)-2-bromopyridine
Purity: 98%
Packaging: 1g
Price: $320
Updated: 2021/12/16

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C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE Chemical Properties,Usage,Production

Synthesis

101990-45-8

120740-10-5

General procedure for the synthesis of 5-aminomethyl-2-bromopyridine from 2-bromo-5-(bromomethyl)pyridine: 2-bromo-5-methylpyridine (70.0 mmol) and N-bromosuccinimide (80.0 mmol) were dissolved in 1,2-dichloroethane (150 mL), followed by addition of 2,2'-azino-bis(2-methylpropionitrile) (1.50 mmol). The reaction mixture was heated at reflux for 15 minutes at 85 °C, another portion of 2,2'-azobis(2-methylpropionitrile) (1.50 mmol) was added and heating was continued at 85 °C for 15 minutes. After completion of the reaction, it was cooled to room temperature and the reaction mixture was allowed to stand at 5 °C for 2 h. The precipitate was collected by filtration and washed with a small amount of 1,2-dichloroethane. The filtrate was concentrated under reduced pressure and the resulting crude product was used directly in the next step of the reaction. The crude 2-bromo-5-(bromomethyl)pyridine was dissolved in chloroform (100 mL) and urotropine (70.0 mmol) was added. The reaction mixture was stirred at room temperature for 16 h. The precipitate was collected by filtration, washed with a little chloroform and dried in air. The resulting urotropin salt was mixed with concentrated hydrochloric acid and refluxed for 90 minutes, cooled to room temperature and then a mixture of 40% aqueous formaldehyde (5.0 mL) and ammonium hydroxide (12 mL) and water (80 mL) was added under stirring. The precipitate was collected by filtration, washed with ice water and dried in a vacuum desiccator. The crude product was purified by recrystallization from ethanol. Yield: 40%, melting point: 105-106 °C. Elemental analysis: calculated value of C5H7BrN2 (187.04): C, 38.53; H, 3.77; N, 14.98. measured value: C, 38.22; H, 3.72; N, 14.71. hplc-MS (ESI+): m/z 188.02 (97.2%). 1H NMR (DMSO-d6): δ 4.04 (t. J=5.67 Hz, 2H, CH2), 7.71 (d, J=8.19 Hz, 1H, ArH), 7.95 (dd, J=8.19, J'=1.95 Hz, 1H, ArH), 8.51 (d, J=1.95 Hz, 1H, ArH), 8.74 (s, br, 2H, NH2).

References

[1] Patent: US2015/368248, 2015, A1. Location in patent: Paragraph 0089
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 15, p. 6234 - 6247

C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE Preparation Products And Raw materials

Raw materials

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C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE Suppliers

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View Lastest Price from C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE manufacturers

Dideu Industries Group Limited

Product: C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE 120740-10-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-23

Shaanxi Dideu Medichem Co. Ltd

Product: 5-AminoMethyl-2-Bromopyridine 120740-10-5
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-12

Career Henan Chemical Co

Product: C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE 120740-10-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

120740-10-5, C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINERelated Search:

Quinolin-5-ylMethanaMine hydrochloride 1,3-THIAZOL-5-YLMETHYLAMINE (4-Bromopyridin-2-yl)methanamine (3-BROMO-PYRIDIN-4-YL)METHYLAMINE C-(5-BROMO-PYRIDIN-3-YL)-METHYLAMINE C-(2-BROMO-PYRIDIN-3-YL)-METHYLAMINE C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE HYDROCHLORIDE C-(2-BROMO-PYRIDIN-4-YL)-METHYLAMINE C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE 6-BROMONICOTINAMIDE 98 2-AMINO-2-(6-BROMOPYRIDIN-3-YL)ACETIC ACID HYDROCHLORIDE 6-BROMO-N-METHOXY-N-METHYLNICOTINAMIDE 4-(6-BROMOPYRIDIN-3-YL)-6-METHYL-2-OXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER DIBROMOCOTININE, HYDROBROMIDE PERBROMIDE 1-(6-BROMO-PYRIDIN-3-YL)-2,2,2-TRIFLUORO-ETHYLAMINE

C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE

5-Aminomethyl-2-Bromopyridine

(2-Bromo-5-pyridinyl)methylamine

(6-broMopyridin-3-yl)MethanaMine

3-Pyridinemethanamine, 6-bromo-

5-(Aminomethyl)-2-bromopyridine 95+%

(6-bromo-3-pyridyl)methanamine

C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE ISO 9001：2015 REACH

6-Bromo-3-pyridinemethanamine

120740-10-5

12074-10-5

Building Blocks

Pyridine