(1R,2S)-VU0155041
- Product Name
- (1R,2S)-VU0155041
- CAS No.
- 1263273-14-8
- Chemical Name
- (1R,2S)-VU0155041
- Synonyms
- 2S)-VU0155041;(1R,2S)-VU0155041;(1R,2S)-VU0155041, 10 mM in DMSO;(1R,2S)VU0155041,(1R,2S) VU0155041,(1R,2S)-VU-0155041;Cyclohexanecarboxylic acid, 2-[[(3,5-dichlorophenyl)amino]carbonyl]-, (1R,2S)-
- CBNumber
- CB13175517
- Molecular Formula
- C14H15Cl2NO3
- Formula Weight
- 316.18
- MOL File
- 1263273-14-8.mol
(1R,2S)-VU0155041 Property
- Boiling point:
- 540.2±50.0 °C(Predicted)
- Density
- 1.429±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 59 mg/mL (186.60 mM)
- form
- Solid
- pka
- 4.48±0.44(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-6849
- Product name
- (1R,2S)-VU0155041
- Purity
- >98.0%
- Packaging
- 5mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- CS-6849
- Product name
- (1R,2S)-VU0155041
- Purity
- >98.0%
- Packaging
- 10mg
- Price
- $132
- Updated
- 2021/12/16
- Product number
- CS-6849
- Product name
- (1R,2S)-VU0155041
- Purity
- >98.0%
- Packaging
- 25mg
- Price
- $264
- Updated
- 2021/12/16
- Product number
- DC10160
- Product name
- (1R,2S)-VU0155041
- Purity
- >98%
- Packaging
- 100mg
- Price
- $600
- Updated
- 2021/12/16
(1R,2S)-VU0155041 Chemical Properties,Usage,Production
Uses
(1R,2S)-VU0155041, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC50 of 2.35 μM.
in vivo
VU0155041 is soluble in an aqueous vehicle and intracerebroventricular administration of 31 to 316 nM of VU0155041 dose-dependently decreases haloperidol-induced catalepsy and reserpine-induced akinesia in rats. VU0155041, at doses of 31 and 92 nmol, is also able to significantly decrease the cataleptic effects of haloperidol, and the effects of the compound are still present 30 min after infusion. Icv infusion of a 316 nmol dose of VU0155041 also results in a significant reversal of akinesia[1].
IC 50
mGluR4
References
[1] Niswender CM, et al. Discovery, characterization, and antiparkinsonian effect of novel positiveallosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol. 2008 Nov;74(5):1345-58. DOI:10.1124/mol.108.049551