Naveglitazar (racemate)
- Product Name
- Naveglitazar (racemate)
- CAS No.
- 916085-47-7
- Chemical Name
- Naveglitazar (racemate)
- Synonyms
- Naveglitazar (racemate);Benzenepropanoic acid, α-methoxy-4-[3-(4-phenoxyphenoxy)propoxy]-
- CBNumber
- CB13175557
- Molecular Formula
- C25H26O6
- Formula Weight
- 422.48
- MOL File
- 916085-47-7.mol
Naveglitazar (racemate) Property
- Boiling point:
- 587.3±50.0 °C(Predicted)
- Density
- 1.198±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 3.54±0.10(Predicted)
Naveglitazar (racemate) Chemical Properties,Usage,Production
Uses
Naveglitazar racemate (LY519818 racemate) is the racemate of Naveglitazar. Naveglitazar is a nonthiozolidinedione peroxisome proliferator-activated receptor (PPAR) α-γ dual, γ-dominant agonist that has shown glucose-lowering potential in animal models[1].
in vivo
[14C]Naveglitazar is quickly absorbed and moderately metabolized before elimination. After oral administration, 47, 31, and 62% of the radioactivity, as assessed by AUC values, are circulating as metabolites in mice, rats, and monkeys, respectively. Half-lives for Naveglitazar and radioactivity are similar within each species; however, monkeys have substantially longer half-lives in comparison to mice and rats. Naveglitazar and radioactivity are slowly cleared from the system circulation in all species evaluated[1].
References
[1] Yi P, et al. The disposition and metabolism of naveglitazar, a peroxisome proliferator-activated receptor alpha-gamma dual, gamma-dominant agonist in mice, rats, and monkeys. Drug Metab Dispos. 2007 Jan;35(1):51-61. DOI:10.1124/dmd.106.012328
Naveglitazar (racemate) Preparation Products And Raw materials
Raw materials
Preparation Products
Naveglitazar (racemate) Suppliers
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4861
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- 17625585511
- Fax
- qq：1580084073
- 1580084073@qq.com
- Country
- China
- ProdList
- 959
- Advantage
- 58
- Tel
- 18024082417
- market@ubiochem.com
- Country
- China
- ProdList
- 9835
- Advantage
- 58
- Tel
- 15002134094
- marketing@targetmol.cn
- Country
- China
- ProdList
- 29573
- Advantage
- 58