HOE 140

Product Name: HOE 140
CAS No.: 130308-48-4
Chemical Name: HOE 140
Synonyms: S-0765;H0E-140;HOE I40;HOE 140;JE-049);Etibant;Icatibant;HOE 140 TFA;Icatibant [inn];HOE 140 USP/EP/BP
CBNumber: CB1318492
Molecular Formula: C59H89N19O13S
Formula Weight: 1304.52
MOL File: 130308-48-4.mol

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HOE 140 Property

Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Water:100.0(Max Conc. mg/mL);76.66(Max Conc. mM)
pka: 3.60±0.21(Predicted)
form: powder
color: white
Water Solubility: Soluble to 1 mg/ml in water
Sequence: H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH
InChIKey: QASONHYHOCRAHL-DOMVFXHKSA-N
CAS DataBase Reference: 130308-48-4

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 3014
Product name: HOE 140
Packaging: 500U
Price: $227
Updated: 2021/12/16

Usbiological

Product number: 255460
Product name: HOE 140
Packaging: 500ug
Price: $480
Updated: 2021/12/16

ChemScene

Product number: CS-3381
Product name: Icatibant
Purity: 99.51%
Packaging: 5mg
Price: $540
Updated: 2021/12/16

AK Scientific

Product number: 3729AH
Product name: Icatibant
Packaging: 5mg
Price: $610
Updated: 2021/12/16

Apolloscientific

Product number: BISN0006
Product name: Icatibant
Purity: 98%
Packaging: 5mg
Price: $660
Updated: 2021/12/16

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HOE 140 Chemical Properties,Usage,Production

Description

Hoe 140 (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin), on bradykinin- and platelet-activating factor (PAF)-induced bronchoconstriction and airway microvascular leakage in anesthetized guinea pigs. Hoe 140 is highly potent and long-acting in inhibiting BK-induced hypotensive responses in the rat. Four hours after s.c. administration of 20nmol kg-1, inhibition still amounted to 60% whereas the effect of 200nmol kg-1 of d-Arg-[Hyp2, Thi5,8, d-Phe7]BK was not significant[1-2].

Uses

Antagonist (bradykinin).

Definition

ChEBI: A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acut attacks of hereditary angioedema in adult patients.

brand name

Metastat (CollaGenex).

storage

Store at -20°C

References

[1] K. Wirth. “Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies.” British Journal of Pharmacology 102 3 (1991): 774–777.
[2] T Sakamoto. “Effect of Hoe 140, a new bradykinin receptor antagonist, on bradykinin- and platelet-activating factor-induced bronchoconstriction and airway microvascular leakage in guinea pig.” European journal of pharmacology 213 3 (1992): 367–73.

HOE 140 Preparation Products And Raw materials

Raw materials

Preparation Products

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HOE 140 Suppliers

China 110 India 5 Japan 1 Switzerland 1 United Kingdom 2 United States 13 Global 132

Tocris Bioscience

Tel: --
Fax: --
Email: customerservice@tocris.co.uk
Country: United Kingdom
ProdList: 5726
Advantage: 77

CMS Chemicals Limited

Tel: --
Fax: --
Email: cms.marketing@cms-chemicals.com
Country: United Kingdom
ProdList: 3708
Advantage: 60

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View Lastest Price from HOE 140 manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: HOE 140 130308-48-4
Price: US $50.00-500.00/g
Min. Order: 10g
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-06-05

Shandong Huizhihan Supply Chain Co., Ltd

Product: Icatibant 130308-48-4
Price: US $0.00-0.00/box
Min. Order: 1box
Purity: 99.99%
Supply Ability: 1000
Release date: 2024-10-30

Shandong Huizhihan Supply Chain Co., Ltd

Product: Icatibant (HOE 140) 130308-48-4
Price: US $0.00-0.00/BOX
Min. Order: 1BOX
Purity: 99%
Supply Ability: 20T
Release date: 2024-11-12

130308-48-4, HOE 140Related Search:

Efegatran N,N-DI-N-BUTYLETHYLENEDIAMINE 2-Amino-N-cyclohexylacetamide 1,2,3,4-Tetrahydroisoquinoline-3-carboxamide HOE 140 2-Aminoethyldiisopropylamine 1-ETHYL-3-PYRROLIDINOL HOE 140 SYNTHETIC >99% SELECTIVE B2 BRAD YKIN 1-METHYL-2-THIOPHEN-2-YL-ETHYLAMINE H-LEU-ARG-OH 3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YL)PROPAN-1-OL CHEMBRDG-BB 9070704 METHYL-(2-THIOPHEN-2-YL-ETHYL)-AMINE 1-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-amine (3R)-1-(2-AMINOETHYL)-3-PYRROLIDINOL N-(2-(BENZYLAMINO)ETHYL) CYCLOHEXANAMINE (R)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID AMIDE N-formylmethamphetamine

RRP-(HYP)-G-(THI)-S-(D-TIC)-(OIC)-R

H-D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG-OH

H2N-D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG-OH

Icatibatide Acetate

Icatibant

D-Arg-[Hyp3,Thi5,D-Tic7,Oic8]bradykinin

D-Arg-L-Arg-L-Pro-L-t4Hyp-Gly-L-Thi-L-Ser-D-Tic-L-Oic-L-Arg-OH

H0E-140

D-Arg-L-Arg-L-Pro-L-t4Hyp-Gly-3-(2-Thienyl)-L-Ala-L-Ser-D-Tic-[(3aS,7aS)-L-Oic-]-OH

Des-Arg9-D-Arg[Hyp3,Thi5,D-Tic7,Oic8]bradykinin

S-0765

138614-30-9 (Acetate)

Icatibant [inn]

L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-

HOE I40

HOE 140

HOE 140 2ACOH 4H2O

D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG

D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG 2ACOH 4H2O

D-ARGINYL-[HYP3,THI5,D-TIC7,OIC8]-BRADYKININ

D-ARGINYL-[HYP3,THI5,D-TIC7,OIC8]-BRADYKININ 2ACOH 4H2O

D-ARGINYL-L-ARGINLYL-L-PROLYL-TRANS-4-HYDROXY-L-PROLYLGLYCYL-3-(2-THIENYL)-L-ALANYL-L-SERYL-D-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBONYL-L-(2ALPHA, 3BETA, 7ABETA)-OCTAHYDRO-1H-INDOLE-2-CARBONYL

D-ARGINYL-L-ARGINLYL-L-PROLYL-TRANS-4-HYDROXY-L-PROLYLGLYCYL-3-(2-THIENYL)-L-ALANYL-L-SERYL-D-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBONYL-L-(2ALPHA,3BETA,7A-BETA)-OCTAHYDRO-1H-INDOLE-2-CARBONYL-L-ARGININE

[DES-ARG10] HOE 140

D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic

D-Arg-L-Arg-L-prolyl-L-Hyp-Gly-L-(2-thienyl)Ala-L-Ser-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3β,7aβ)-octahydro-1H-indole-2-carboxylic acid

Icatibant (HOE-140

JE-049)

Nw-(((S)-2-(2-((2S,4R)-1-(D-arginyl-L-arginyl-L-prolyl)-4-hydroxypyrrolidine-2-carboxamido)acetamido)-3-(thiophen-2-yl)propanoyl)-L-seryl)-N2-((3aS,7aS)-octahydro-1H-indole-2-carbonyl)-N2-((R)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-arginine

L-Arginine, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-

HOE 140 USP/EP/BP

Etibant

HOE 140 TFA

((2S,3aS,7aS)-1-((R)-2-(((S)-2-(2-((2S,4R)-1-(D-Arginyl-L-arginyl-L-prolyl)-4-hydroxypyrrolidine-2-carboxamido)acetamido)-3-(thiophen-2-yl)propanoyl)-L-seryl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)octahydro-1H-indole-2-carbonyl)-L-arginine

Phytol Impurity 3

130308-48-4

C53H77N15O12S

C59H90N20O12S

peptide