ChemicalBook > CAS DataBase List > HOE 140

HOE 140

Product Name
HOE 140
CAS No.
130308-48-4
Chemical Name
HOE 140
Synonyms
S-0765;H0E-140;HOE I40;HOE 140;JE-049);Etibant;Icatibant;HOE 140 TFA;Icatibant [inn];HOE 140 USP/EP/BP
CBNumber
CB1318492
Molecular Formula
C59H89N19O13S
Formula Weight
1304.52
MOL File
130308-48-4.mol
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HOE 140 Property

Density 
1.60±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
Water:100.0(Max Conc. mg/mL);76.66(Max Conc. mM)
pka
3.60±0.21(Predicted)
form 
powder
color 
white
Water Solubility 
Soluble to 1 mg/ml in water
Sequence
H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH
InChIKey
QASONHYHOCRAHL-DOMVFXHKSA-N
CAS DataBase Reference
130308-48-4
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
3014
Product name
HOE 140
Packaging
500U
Price
$227
Updated
2021/12/16
Usbiological
Product number
255460
Product name
HOE 140
Packaging
500ug
Price
$480
Updated
2021/12/16
ChemScene
Product number
CS-3381
Product name
Icatibant
Purity
99.51%
Packaging
5mg
Price
$540
Updated
2021/12/16
AK Scientific
Product number
3729AH
Product name
Icatibant
Packaging
5mg
Price
$610
Updated
2021/12/16
Apolloscientific
Product number
BISN0006
Product name
Icatibant
Purity
98%
Packaging
5mg
Price
$660
Updated
2021/12/16
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HOE 140 Chemical Properties,Usage,Production

Description

Hoe 140 (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin), on bradykinin- and platelet-activating factor (PAF)-induced bronchoconstriction and airway microvascular leakage in anesthetized guinea pigs. Hoe 140 is highly potent and long-acting in inhibiting BK-induced hypotensive responses in the rat. Four hours after s.c. administration of 20nmol kg-1, inhibition still amounted to 60% whereas the effect of 200nmol kg-1 of d-Arg-[Hyp2, Thi5,8, d-Phe7]BK was not significant[1-2].

Uses

Antagonist (bradykinin).

Definition

ChEBI: A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acut attacks of hereditary angioedema in adult patients.

brand name

Metastat (CollaGenex).

Biological Activity

Hoe 140 is highly potent and long-acting in inhibiting BK-induced hypotensive responses in the rat. Four hours after s.c. administration of 20 nmol kg?1, inhibition still amounted to 60%, whereas the effect of 200 nmol kg?1 of d-Arg—[Hyp2, Thi5,8, d-Phe7]BK was not significant. In receptor binding studies in guinea-pig ileum preparations, Hoe 140 showed an IC50 of 1.07 × 10?9mol l?1 and a KI value of 7.98 × 10?10 mol l?1.

storage

Store at -20°C

References

[1] K. Wirth. “Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies.” British Journal of Pharmacology 102 3 (1991): 774–777.
[2] T Sakamoto. “Effect of Hoe 140, a new bradykinin receptor antagonist, on bradykinin- and platelet-activating factor-induced bronchoconstriction and airway microvascular leakage in guinea pig.” European journal of pharmacology 213 3 (1992): 367–73.

HOE 140 Preparation Products And Raw materials

Raw materials

Preparation Products

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HOE 140 Suppliers

China 113 India 5 Japan 1 Switzerland 1 United Kingdom 2 United States 13 Global 135
MedChemexpress LLC
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BIOMOL INTERNATIONAL, LP
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View Lastest Price from HOE 140 manufacturers

Shandong Huizhihan Supply Chain Co., Ltd
Product
Icatibant (HOE 140) 130308-48-4
Price
US $0.00-0.00/BOX
Min. Order
1BOX
Purity
99%
Supply Ability
20T
Release date
2024-11-12
Shandong Huizhihan Supply Chain Co., Ltd
Product
Icatibant 130308-48-4
Price
US $0.00-0.00/box
Min. Order
1box
Purity
99.99%
Supply Ability
1000
Release date
2024-10-30
hebei hongtan Biotechnology Co., Ltd
Product
HOE 140 130308-48-4
Price
US $50.00-500.00/g
Min. Order
10g
Purity
98%
Supply Ability
2000kg
Release date
2024-06-05

130308-48-4, HOE 140Related Search:

Efegatran N,N-DI-N-BUTYLETHYLENEDIAMINE 2-Amino-N-cyclohexylacetamide 1,2,3,4-Tetrahydroisoquinoline-3-carboxamide HOE 140 2-Aminoethyldiisopropylamine 1-ETHYL-3-PYRROLIDINOL HOE 140 SYNTHETIC >99% SELECTIVE B2 BRAD YKIN 1-METHYL-2-THIOPHEN-2-YL-ETHYLAMINE H-LEU-ARG-OH 3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YL)PROPAN-1-OL CHEMBRDG-BB 9070704 METHYL-(2-THIOPHEN-2-YL-ETHYL)-AMINE 1-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-amine (3R)-1-(2-AMINOETHYL)-3-PYRROLIDINOL N-(2-(BENZYLAMINO)ETHYL) CYCLOHEXANAMINE (R)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID AMIDE N-formylmethamphetamine

  • RRP-(HYP)-G-(THI)-S-(D-TIC)-(OIC)-R
  • H-D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG-OH
  • H2N-D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG-OH
  • Icatibatide Acetate
  • Icatibant
  • D-Arg-[Hyp3,Thi5,D-Tic7,Oic8]bradykinin
  • D-Arg-L-Arg-L-Pro-L-t4Hyp-Gly-L-Thi-L-Ser-D-Tic-L-Oic-L-Arg-OH
  • H0E-140
  • D-Arg-L-Arg-L-Pro-L-t4Hyp-Gly-3-(2-Thienyl)-L-Ala-L-Ser-D-Tic-[(3aS,7aS)-L-Oic-]-OH
  • Des-Arg9-D-Arg[Hyp3,Thi5,D-Tic7,Oic8]bradykinin
  • S-0765
  • 138614-30-9 (Acetate)
  • Icatibant [inn]
  • L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-
  • HOE I40
  • HOE 140
  • HOE 140 2ACOH 4H2O
  • D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG
  • D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG 2ACOH 4H2O
  • D-ARGINYL-[HYP3,THI5,D-TIC7,OIC8]-BRADYKININ
  • D-ARGINYL-[HYP3,THI5,D-TIC7,OIC8]-BRADYKININ 2ACOH 4H2O
  • D-ARGINYL-L-ARGINLYL-L-PROLYL-TRANS-4-HYDROXY-L-PROLYLGLYCYL-3-(2-THIENYL)-L-ALANYL-L-SERYL-D-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBONYL-L-(2ALPHA, 3BETA, 7ABETA)-OCTAHYDRO-1H-INDOLE-2-CARBONYL
  • D-ARGINYL-L-ARGINLYL-L-PROLYL-TRANS-4-HYDROXY-L-PROLYLGLYCYL-3-(2-THIENYL)-L-ALANYL-L-SERYL-D-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBONYL-L-(2ALPHA,3BETA,7A-BETA)-OCTAHYDRO-1H-INDOLE-2-CARBONYL-L-ARGININE
  • [DES-ARG10] HOE 140
  • D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic
  • D-Arg-L-Arg-L-prolyl-L-Hyp-Gly-L-(2-thienyl)Ala-L-Ser-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3β,7aβ)-octahydro-1H-indole-2-carboxylic acid
  • Icatibant (HOE-140
  • JE-049)
  • Nw-(((S)-2-(2-((2S,4R)-1-(D-arginyl-L-arginyl-L-prolyl)-4-hydroxypyrrolidine-2-carboxamido)acetamido)-3-(thiophen-2-yl)propanoyl)-L-seryl)-N2-((3aS,7aS)-octahydro-1H-indole-2-carbonyl)-N2-((R)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-arginine
  • L-Arginine, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-
  • HOE 140 USP/EP/BP
  • Etibant
  • HOE 140 TFA
  • ((2S,3aS,7aS)-1-((R)-2-(((S)-2-(2-((2S,4R)-1-(D-Arginyl-L-arginyl-L-prolyl)-4-hydroxypyrrolidine-2-carboxamido)acetamido)-3-(thiophen-2-yl)propanoyl)-L-seryl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)octahydro-1H-indole-2-carbonyl)-L-arginine
  • Phytol Impurity 3
  • 130308-48-4
  • C53H77N15O12S
  • C59H90N20O12S
  • peptide