2,5-Pyrrolidinedione, 1-[(6-azido-1-oxohexyl)oxy]-

Product Name: 2,5-Pyrrolidinedione, 1-[(6-azido-1-oxohexyl)oxy]-
CAS No.: 866363-70-4
Chemical Name: 2,5-Pyrrolidinedione, 1-[(6-azido-1-oxohexyl)oxy]-
Synonyms: N3-C5-NHS;N3-C5-NHSeste;N3-C5-NHS ester;6-Azidohexanoic acid NHS ester;N3-C5-NHS ester, 10 mM in DMSO;6-Azidohexanoic Acid NHS Ester (CCT-1402);2,5-dioxopyrrolidin-1-yl 6-azidohexanoate;1-[(6-Azidohexanoyl)oxy]pyrrolidine-2,5-dione;6-Azidocaproic acid N-hydroxysuccinimidyl ester;2,5-Pyrrolidinedione, 1-[(6-azido-1-oxohexyl)oxy]-
CBNumber: CB13269177
Molecular Formula: C10H14N4O4
Formula Weight: 254.25
MOL File: 866363-70-4.mol

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2,5-Pyrrolidinedione, 1-[(6-azido-1-oxohexyl)oxy]- Property

storage temp.: Storage temp. -20°C
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

Signal word: Warning

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N-Bromosuccinimide Price

Iris Biotech GmbH

Product number: RL-2980
Product name: N3-Aca-OSu
Packaging: 500mg
Price: $432
Updated: 2021/12/16

ChemScene

Product number: CS-0105081
Product name: N3-C5-NHSester
Packaging: 100mg
Price: $460
Updated: 2021/12/16

Iris Biotech GmbH

Product number: RL-2980
Product name: N3-Aca-OSu
Packaging: 1g
Price: $648
Updated: 2021/12/16

BroadPharm

Product number: BP-25454
Product name: Azido-Aca-NHS
Purity: 97%
Packaging: 1g
Price: $650
Updated: 2021/12/16

Matrix Scientific

Product number: 180022
Product name: Hexanoic acid
Purity: 6-azido-2,5-dioxo-1-pyrrolidinyl ester95%
Packaging: 1g
Price: $990
Updated: 2021/12/16

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2,5-Pyrrolidinedione, 1-[(6-azido-1-oxohexyl)oxy]- Chemical Properties,Usage,Production

Description

Azido-Aca-NHS has an azide and NHS ester end group. The azide can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. The NHS ester can react with amine groups to form stable amide bonds.

Uses

N3-C5-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-C5-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Non-cleavable Linker

References

[1] Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507. DOI:10.1021/acs.jmedchem.7b00736

2,5-Pyrrolidinedione, 1-[(6-azido-1-oxohexyl)oxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

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2,5-Pyrrolidinedione, 1-[(6-azido-1-oxohexyl)oxy]- Suppliers

China 38 United States 6 Global 44

Okeanos Tech Co,. Ltd.

Tel: 010-62651721 18610486005
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Country: China
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Advantage: 58

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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Country: China
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Beijing Jin Ming Biotechnology Co., Ltd.

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Amatek Scientific Co. Ltd.

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Xi'an Confluore Biological Technology Co., Ltd.

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Fan De(Beijing) Biotechnology Co., Ltd.

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Henan Alpha Chemical Co., Ltd.

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Alfa Chemistry

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View Lastest Price from 2,5-Pyrrolidinedione, 1-[(6-azido-1-oxohexyl)oxy]- manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: N3-C5-NHS ester 866363-70-4
Price: US $0.00/mg
Min. Order: 250mg
Purity: >95.00%
Supply Ability: 250mg
Release date: 2024-03-22

866363-70-4, 2,5-Pyrrolidinedione, 1-[(6-azido-1-oxohexyl)oxy]-Related Search:

2,5-Pyrrolidinedione, 1-[(6-azido-1-oxohexyl)oxy]-

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1-[(6-Azidohexanoyl)oxy]pyrrolidine-2,5-dione - [A1963]

866363-70-4