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MELOXICAM-D3

Product Name
MELOXICAM-D3
CAS No.
942047-63-4
Chemical Name
MELOXICAM-D3
Synonyms
Mobic-d3;Metacam-d3;Parocin-d3;Movatec-d3;Movalis-d3;Mobicox-d3;MELOXICAM-D3;Meloxicam D4;[2H3]-Meloxicam;Meloxicam-d3
CBNumber
CB1327322
Molecular Formula
C14H13N3O4S2
Formula Weight
351.4
MOL File
Mol file
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MELOXICAM-D3 Property

Melting point:
249-251°C
storage temp. 
-20°C Freezer
solubility 
DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form 
Solid
color 
Light yellow to yellow
CAS DataBase Reference
942047-63-4
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Safety

Hazard Codes 
Xn
Risk Statements 
22
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
34109
Product name
Meloxicam-d3
Purity
VETRANAL?, analytical standard
Packaging
50mg
Price
$856
Updated
2022/05/15
Cayman Chemical
Product number
25508
Product name
Meloxicam-d3
Purity
≥99% deuterated forms (d1-d3)
Packaging
500μg
Price
$175
Updated
2024/03/01
Cayman Chemical
Product number
25508
Product name
Meloxicam-d3
Purity
≥99% deuterated forms (d1-d3)
Packaging
1mg
Price
$330
Updated
2024/03/01
TRC
Product number
M216102
Product name
Meloxicam-d3
Packaging
1mg
Price
$175
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0006923
Product name
MELOXICAM-D3
Purity
95.00%
Packaging
10MG
Price
$1871.1
Updated
2021/12/16
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MELOXICAM-D3 Chemical Properties,Usage,Production

Description

Meloxicam-d3 is intended for use as an internal standard for the quantification of meloxicam by GC- or LC-MS. Meloxicam is a selective inhibitor of COX-2 (IC50s = 11.8 and 143 μM for COX-2 and COX-1, respectively, in an enzyme activity assay) and a non-steroidal anti-inflammatory drug (NSAID). Meloxicam (0.03%) reduces croton oil-induced increases in TNF-α and IL-1β mRNA levels and increases IL-10 mRNA levels in cornea in a rabbit model of acute ocular inflammation. It inhibits pleural plasma exudation in a carrageenan-induced rat model of pleurisy when administered at a dose of 3 mg/kg.In a canine model of unilateral osteoarthritis of the right stifle joint, meloxicam reduces prostaglandin E2 (PGE2) levels in plasma and right stifle joint synovial fluid when administered at a dose of 0.2 mg/kg. Formulations containing meloxicam have been used in the treatment of osteoarthritis and rheumatoid arthritis.

Chemical Properties

Yellow Solid

Uses

MELOXICAM-D3 is a preferential cyclooxygenase (COX-2) inhibitor,it is used as an anti-inflammatory.

References

1. Ogino, K., Hatanaka, K., Kawamura, M., et al. Evaluation of pharmacological profile of meloxicam as an anti-inflammatory agent, with particular reference to its relative selectivity for cyclooxygenase-2 over cyclooxygenase-1. Pharmacology 55, 44-53 (1997).
2. Cruz, R., Quintana-Hau, J.D., González, J.R., et al. Effects of an ophthalmic formulation of meloxicam on COX-2 expression, PGE2 release, and cytokine expression in a model of acute ocular inflammation. Br. J. Ophthalmol. 92, 120-125 (2008).
3. Jones, C.J., Streppa, H.K., Harmon, B.G., et al. In vivo effects of meloxicam and aspirin on blood, gasteric mucosal, and synovial fluid prosanoid synthesis in dogs. Am. J. Vet. Res. 63, 1527-1531 (2002).

MELOXICAM-D3 Preparation Products And Raw materials

Raw materials

Preparation Products

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MELOXICAM-D3 Suppliers

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942047-63-4, MELOXICAM-D3Related Search:


  • 4-HYDROXY-2-(METHYL-D3)-1,1-DIOXO-BENZO[E]-1,2-THIAZINE-3-CARBOXYLIC ACID (5-METHYL-2-THIAZOLYL)AMIDE
  • MELOXICAM-D3
  • 4-Hydroxy-2-(methyl-d3)-1,1-dioxo-benzo[e]-1,2-thiazine-3-carboxylic acid (5-methyl-2-thiazolyl)amide
  • Meloxicam-d<sub>3</sub>
  • 4-Hydroxy-2-(methyl-d3)-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1,-Dioxide
  • Metacam-d3
  • Mobic-d3
  • Mobicox-d3
  • Movalis-d3
  • Movatec-d3
  • Parocin-d3
  • 4-hydroxy-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-2-(trideuteriomethyl)-1λ<sup>6</sup>,2-benzothiazine-3-carboxamide
  • 4-hydroxy-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-2-(trideuteriomethyl)-1λ^{6},2-benzothiazine-3-carboxamide
  • 4-hydroxy-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-2-(trideuteriomethyl)-1$l^{6},2-benzothiazine-3-carboxamide
  • [2H3]-Meloxicam
  • Meloxicam D4
  • 4-hydroxy-2-(2H?)methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-2H-1λ?,2-benzothiazine-3-carboxamide
  • 942047-63-4
  • C14H10D3N3O4S2
  • Isotope Labelled Compounds
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Isotope Labeled Compounds
  • Pharmaceuticals
  • Sulfur & Selenium Compounds