MELOXICAM-D3

Product Name: MELOXICAM-D3
CAS No.: 942047-63-4
Chemical Name: MELOXICAM-D3
Synonyms: Mobic-d3;Metacam-d3;Parocin-d3;Movatec-d3;Movalis-d3;Mobicox-d3;MELOXICAM-D3;Meloxicam D4;[2H3]-Meloxicam;Meloxicam-d3
CBNumber: CB1327322
Molecular Formula: C14H13N3O4S2
Formula Weight: 351.4
MOL File: Mol file

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MELOXICAM-D3 Property

Melting point:: 249-251°C
storage temp.: -20°C Freezer
solubility: DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
CAS DataBase Reference: 942047-63-4

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Safety

Hazard Codes: Xn
Risk Statements: 22
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 34109
Product name: Meloxicam-d3
Purity: VETRANAL?, analytical standard
Packaging: 50mg
Price: $856
Updated: 2022/05/15

Cayman Chemical

Product number: 25508
Product name: Meloxicam-d3
Purity: ≥99% deuterated forms (d1-d3)
Packaging: 500μg
Price: $175
Updated: 2024/03/01

Cayman Chemical

Product number: 25508
Product name: Meloxicam-d3
Purity: ≥99% deuterated forms (d1-d3)
Packaging: 1mg
Price: $330
Updated: 2024/03/01

TRC

Product number: M216102
Product name: Meloxicam-d3
Packaging: 1mg
Price: $175
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0006923
Product name: MELOXICAM-D3
Purity: 95.00%
Packaging: 10MG
Price: $1871.1
Updated: 2021/12/16

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MELOXICAM-D3 Chemical Properties,Usage,Production

Description

Meloxicam-d3 is intended for use as an internal standard for the quantification of meloxicam by GC- or LC-MS. Meloxicam is a selective inhibitor of COX-2 (IC50s = 11.8 and 143 μM for COX-2 and COX-1, respectively, in an enzyme activity assay) and a non-steroidal anti-inflammatory drug (NSAID). Meloxicam (0.03%) reduces croton oil-induced increases in TNF-α and IL-1β mRNA levels and increases IL-10 mRNA levels in cornea in a rabbit model of acute ocular inflammation. It inhibits pleural plasma exudation in a carrageenan-induced rat model of pleurisy when administered at a dose of 3 mg/kg.In a canine model of unilateral osteoarthritis of the right stifle joint, meloxicam reduces prostaglandin E2 (PGE2) levels in plasma and right stifle joint synovial fluid when administered at a dose of 0.2 mg/kg. Formulations containing meloxicam have been used in the treatment of osteoarthritis and rheumatoid arthritis.

Chemical Properties

Yellow Solid

Uses

MELOXICAM-D3 is a preferential cyclooxygenase (COX-2) inhibitor,it is used as an anti-inflammatory.

References

1. Ogino, K., Hatanaka, K., Kawamura, M., et al. Evaluation of pharmacological profile of meloxicam as an anti-inflammatory agent, with particular reference to its relative selectivity for cyclooxygenase-2 over cyclooxygenase-1. Pharmacology 55, 44-53 (1997).
2. Cruz, R., Quintana-Hau, J.D., González, J.R., et al. Effects of an ophthalmic formulation of meloxicam on COX-2 expression, PGE2 release, and cytokine expression in a model of acute ocular inflammation. Br. J. Ophthalmol. 92, 120-125 (2008).
3. Jones, C.J., Streppa, H.K., Harmon, B.G., et al. In vivo effects of meloxicam and aspirin on blood, gasteric mucosal, and synovial fluid prosanoid synthesis in dogs. Am. J. Vet. Res. 63, 1527-1531 (2002).

MELOXICAM-D3 Preparation Products And Raw materials

Raw materials

Preparation Products

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MELOXICAM-D3 Suppliers

Canada 2 China 32 France 1 India 5 Switzerland 1 United States 5 Global 46

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942047-63-4, MELOXICAM-D3Related Search:

IODOMETHANE-D3 Meloxicam

4-HYDROXY-2-(METHYL-D3)-1,1-DIOXO-BENZO[E]-1,2-THIAZINE-3-CARBOXYLIC ACID (5-METHYL-2-THIAZOLYL)AMIDE

MELOXICAM-D3

4-Hydroxy-2-(methyl-d3)-1,1-dioxo-benzo[e]-1,2-thiazine-3-carboxylic acid (5-methyl-2-thiazolyl)amide

Meloxicam-d<sub>3</sub>

4-Hydroxy-2-(methyl-d3)-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1,-Dioxide

Metacam-d3

Mobic-d3

Mobicox-d3

Movalis-d3

Movatec-d3

Parocin-d3

4-hydroxy-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-2-(trideuteriomethyl)-1λ<sup>6</sup>,2-benzothiazine-3-carboxamide

4-hydroxy-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-2-(trideuteriomethyl)-1λ^{6},2-benzothiazine-3-carboxamide

4-hydroxy-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-2-(trideuteriomethyl)-1$l^{6},2-benzothiazine-3-carboxamide

[2H3]-Meloxicam

Meloxicam D4

942047-63-4

C14H10D3N3O4S2

Isotope Labelled Compounds

Heterocycles

Intermediates & Fine Chemicals

Isotope Labeled Compounds

Pharmaceuticals

Sulfur & Selenium Compounds