2,4-DICHLORO-6-METHOXYQUINOLINE
- Product Name
- 2,4-DICHLORO-6-METHOXYQUINOLINE
- CAS No.
- 70049-46-6
- Chemical Name
- 2,4-DICHLORO-6-METHOXYQUINOLINE
- Synonyms
- 2,4-DICHLORO-6-METHOXYQUINOLINE;Quinoline, 2,4-dichloro-6-methoxy-
- CBNumber
- CB1329407
- Molecular Formula
- C10H7Cl2NO
- Formula Weight
- 228.07
- MOL File
- 70049-46-6.mol
2,4-DICHLORO-6-METHOXYQUINOLINE Property
- Boiling point:
- 327.9±37.0 °C(Predicted)
- Density
- 1.384±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.09±0.50(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D483403
- Product name
- 2,4-Dichloro-6-methoxyquinoline
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FD42337
- Product name
- 2,4-Dichloro-6-methoxyquinoline
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FD42337
- Product name
- 2,4-Dichloro-6-methoxyquinoline
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FD42337
- Product name
- 2,4-Dichloro-6-methoxyquinoline
- Packaging
- 250mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FD42337
- Product name
- 2,4-Dichloro-6-methoxyquinoline
- Packaging
- 500mg
- Price
- $300
- Updated
- 2021/12/16
2,4-DICHLORO-6-METHOXYQUINOLINE Chemical Properties,Usage,Production
Synthesis Reference(s)
Synthesis, p. 623, 1993 DOI: 10.1055/s-1993-25914
Synthesis
141-82-2
104-94-9
70049-46-6
1. In a 3-necked round-bottomed flask fitted with a condenser and a room temperature stirring bar, phosphorus (V) chloride oxide (40 mL, 1.5 M) and malonic acid (6.244 g, 60.00 mmol) were added. 2. p-Aminoanisole (9.236 g, 75.00 mmol) was added in small portions over 15 minutes under stirring conditions through an open neck portion of the round bottom flask. 3. The reaction mixture was heated to reflux and stirred continuously for 5 hours. 4. Upon completion of the reaction, the mixture was cooled to room temperature and then slowly poured into crushed ice (700 mL). 5. The pH of the resulting aqueous solution was adjusted to 10 with concentrated ammonium hydroxide (85 mL). 6. The aqueous phase was extracted using dichloromethane and the organic layers were combined. 7. The organic layer was dried over anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. 8. The crude product was purified by column chromatography (eluent: 0-5% hexane solution of ethyl acetate) to afford 2,4-dichloro-6-methoxyquinoline as a pale yellow solid (4.7812 g, 35% yield). 9. Characterization of the product: melting point 170.5-171.5 °C; thin-layer chromatography (TLC) Rf = 0.27 (2% ethyl acetate/hexane); infrared spectroscopy (thin-film) νmax 3084, 3013, 2982, 1623, 1562, 1499 cm-1; 1H NMR (500 MHz, CDCl3) δ 7.90 (d, J = 9.0 Hz, 1H), 7.45 (s, 1H), 7.5 (s, 1H). , 7.45 (s, 1H), 7.40 (dd, J = 9.0, 3.0 Hz, 1H), 7.36 (d, J = 3.0 Hz, 1H), 3.96 (s, 3H); 13C NMR (125 MHz, CDCl3) δ 158.9, 147.0, 144.0, 142.6, 130.4, 126.3, 124.1, 122.0, 101.9, 55.7; high-resolution mass spectrometry data have been submitted.
References
[1] Heterocyclic Communications, 2001, vol. 7, # 4, p. 353 - 358
[2] Research on Chemical Intermediates, 2014, vol. 40, # 5, p. 1851 - 1866
[3] Medicinal Chemistry, 2015, vol. 11, # 8, p. 789 - 797
[4] Patent: US2012/88915, 2012, A1. Location in patent: Page/Page column 14
[5] Chemistry of Heterocyclic Compounds, 2015, vol. 51, # 3, p. 250 - 258
2,4-DICHLORO-6-METHOXYQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-DICHLORO-6-METHOXYQUINOLINE manufacturers
- Product
- 2,4-DICHLORO-6-METHOXYQUINOLINE 70049-46-6
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-08-05