ChemicalBook > CAS DataBase List > METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE

METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE

Product Name: METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE
CAS No.: 95201-93-7
Chemical Name: METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE
Synonyms: Methyl-4-bromo-3-hydroxythophene2-carboxylate;4-Bromo-3-hydroxy-2-(methoxycarbonyl)thiophene;Methyl 4-bromo-3-hydroxythiophene-3-carboxylate;methyl 3-hydroxy-4-bromo-2-thiophenecarboxylate;METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE;methyl-3-hydroxy-4-bromo thiophen-2-carboxylate;(4-bromo-3-oxo-2-thiophenylidene)-methoxymethanolate;4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER;2-Thiophenecarboxylic acid, 4-bromo-3-hydroxy-, methyl ester;METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE ISO 9001：2015 REACH
CBNumber: CB1329942
Molecular Formula: C6H5BrO3S
Formula Weight: 237.07
MOL File: 95201-93-7.mol

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METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE Property

Melting point:: 79-80°C
Boiling point:: 247.9±35.0℃ (760 Torr)
Density: 1.803±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:: 103.7±25.9℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 7.93±0.15(Predicted)
Appearance: White to off-white Solid
Water Solubility: Sparingly Soluble in water 0.95 g/L @ 25°C.
InChI: InChI=1S/C6H5BrO3S/c1-10-6(9)5-4(8)3(7)2-11-5/h2,8H,1H3
InChIKey: UFTXASQYKJFRKI-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)SC=C(Br)C=1O
CAS DataBase Reference: 95201-93-7

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-37/39
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M296530
Product name: Methyl4-Bromo-3-hydroxythiophene-2-carboxylate
Packaging: 500mg
Price: $110
Updated: 2021/12/16

Matrix Scientific

Product number: 083434
Product name: Methyl 4-bromo-3-hydroxythiophene-2-carboxylate
Purity: 97%
Packaging: 1g
Price: $120
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6H29-9-01
Product name: Methyl 4-bromo-3-hydroxythiophene-2-carboxylate
Packaging: 1g
Price: $144
Updated: 2021/12/16

AK Scientific

Product number: 4216AF
Product name: Methyl4-bromo-3-hydroxythiophene-2-carboxylate
Packaging: 250mg
Price: $107
Updated: 2021/12/16

Matrix Scientific

Product number: 083434
Product name: Methyl 4-bromo-3-hydroxythiophene-2-carboxylate
Purity: 97%
Packaging: 10g
Price: $756
Updated: 2021/12/16

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METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE Chemical Properties,Usage,Production

Uses

The synthesis of the thienopyranone scaffold began with the alkylation of methyl 4-bromo-3-hydroxythiophene-2-carboxylate with N-acetylmorpholine.

Synthesis

5118-06-9

95201-93-7

General procedure for the synthesis of methyl 4-bromo-3-hydroxythiophene-2-carboxylate from methyl 3-hydroxy-2-thiophenecarboxylate: 3.24 mL (63.2 mmol) of bromine was slowly added to a solution of 10 g (63.2 mmol) of methyl 3-hydroxy-2-thiophenecarboxylate in 22 mL of acetic acid and the reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the reaction solution was poured into 50 mL of water and extracted with 50 mL of dichloromethane. The organic phases were combined, washed twice with 50 mL of water and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by rapid chromatography on silica gel (eluent: dichloromethane/petroleum ether, 1:2) to give 11.3 g methyl 4-bromo-3-hydroxythiophene-2-carboxylate in 76% yield. The melting point of the product was 86 °C. 1H NMR (CDCl3): δ 3.92 (s, 3H), 7.38 (s, 1H), 9.74 (s, 1H). 13C NMR (CDCl3): δ 52.2, 102.6, 103.8, 128.1, 160.4, 165.8. MS (EI): m/z = 236 (M+.). .

References

[1] Tetrahedron Letters, 2009, vol. 50, # 35, p. 5005 - 5008
[2] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1288 - 1291
[3] Synthesis, 1984, vol. NO. 10, p. 847 - 850
[4] Tetrahedron Letters, 2017, vol. 58, # 26, p. 2537 - 2541
[5] Patent: US4748183, 1988, A

METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE Suppliers

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View Lastest Price from METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE 95201-93-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-03-13

Shaanxi Dideu Medichem Co. Ltd

Product: METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE 95201-93-7
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-04-27

Career Henan Chemical Co

Product: METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE 95201-93-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

95201-93-7, METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATERelated Search:

methyl 4-bromo-3-methylthiophene-2-carboxylate METHYL THIOPHENE-2-CARBOXYLATE 3-Hydroxythiophene-2-carboxylic acid AKOS 92282 METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE METHYL 4-BROMO-3-[(2,3,3-TRICHLOROACRYLOYL)OXY]THIOPHENE-2-CARBOXYLATE AKOS 92298 METHYL 4,5-DIBROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE METHYL 4-BROMO-3-METHOXYTHIOPHENE-2-CARBOXYLATE METHYL 4,5-DIBROMO-3-METHOXYTHIOPHENE-2-CARBOXYLATE

METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE

4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER

4-Bromo-3-hydroxy-2-(methoxycarbonyl)thiophene

methyl 3-hydroxy-4-bromo-2-thiophenecarboxylate

(4-bromo-3-oxo-2-thiophenylidene)-methoxymethanolate

2-Thiophenecarboxylic acid, 4-bromo-3-hydroxy-, methyl ester

METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE ISO 9001：2015 REACH

methyl-3-hydroxy-4-bromo thiophen-2-carboxylate

Methyl-4-bromo-3-hydroxythophene2-carboxylate

Methyl 4-bromo-3-hydroxythiophene-3-carboxylate

95201-93-7

C6H6BrO3S

Esters

Thiophenes & Benzothiophenes