ChemicalBook > CAS DataBase List > Pam2CSK4
Pam2CSK4
- Product Name
- Pam2CSK4
- CAS No.
- 868247-72-7
- Chemical Name
- Pam2CSK4
- Synonyms
- Pam2CSK4;L-Lysine, S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-
- CBNumber
- CB13310330
- Molecular Formula
- C65H126N10O12S
- Formula Weight
- 1271.82
- MOL File
- 868247-72-7.mol
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Pam2CSK4 Property
- Boiling point:
- 1302.9±65.0 °C(Predicted)
- Density
- 1.091±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble to 1 mg/ml in 0.25% acetic acid
- form
- Powder
- pka
- 3.27±0.10(Predicted)
- color
- White
- Sequence
- {(2R)-2,3-Bis(1-oxohexadecyl)oxy]propyl}-Cys-Ser-Lys-Lys-Lys-Lys
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N-Bromosuccinimide Price
Tocris
- Product number
- 4637
- Product name
- Pam2CSK4
- Packaging
- 1
- Price
- $195
- Updated
- 2021/12/16
Usbiological
- Product number
- 256158
- Product name
- Pam2CSK4
- Packaging
- 1mg
- Price
- $446
- Updated
- 2021/12/16
Usbiological
- Product number
- 256159
- Product name
- Pam2CSK4
- Packaging
- 100ug
- Price
- $460
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B5665
- Product name
- Pam2CSK4
- Packaging
- 1mg
- Price
- $282
- Updated
- 2021/12/16
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Pam2CSK4 Chemical Properties,Usage,Production
Uses
Pam2CSK4, a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 also activates iNOS expression and NO production in mouse macrophages[1][2][3].
storage
-20°C
References
[1] Parra-Izquierdo I, et al. The Toll-Like Receptor 2 Ligand Pam2CSK4 Activates Platelet Nuclear Factor-κB and Bruton's Tyrosine Kinase Signaling to Promote Platelet-Endothelial Cell Interactions. Front Immunol. 2021 Aug 30;12:729951. DOI:10.3389/fimmu.2021.729951
[2] Kulsantiwong P, et al. Pam2CSK4 and Pam3CSK4 induce iNOS expression via TBK1 and MyD88 molecules in mouse macrophage cell line RAW264.7. Inflamm Res. 2017 Oct;66(10):843-853. DOI:10.1007/s00011-017-1063-1
[3] Kaur A, et al. An efficient and scalable synthesis of potent TLR2 agonistic PAM2CSK4. RSC Adv. 2018 Mar 5;8(18):9587-9596. DOI:10.1039/c8ra01387j
Pam2CSK4 Preparation Products And Raw materials
Raw materials
Preparation Products
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