ChemicalBook > CAS DataBase List > Palifosfamide tromethamine
Palifosfamide tromethamine
- Product Name
- Palifosfamide tromethamine
- CAS No.
- 1070409-31-2
- Chemical Name
- Palifosfamide tromethamine
- Synonyms
- IPM tromethamine;ZIO-201 tromethamine;Palifosfamide tromethamine;IPM tromethamine|||Isophosphoramide mustard tromethamine|||ZIO-201 tromethamine|||Isophosphoramide mustard tromethamine
- CBNumber
- CB13333746
- Molecular Formula
- C8H22Cl2N3O5P
- Formula Weight
- 342.15
- MOL File
- 1070409-31-2.mol
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Palifosfamide tromethamine Chemical Properties,Usage,Production
Uses
Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.
References
[1] Jones B, Komarnitsky P, Miller GT, Amedio J, Wallner BP. Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin. Anticancer Drugs. 2012;23(2):173-184. DOI:10.1097/CAD.0b013e32834d73a6
Palifosfamide tromethamine Preparation Products And Raw materials
Raw materials
Preparation Products
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