Cyanine5 maleimide

Product Name: Cyanine5 maleimide
CAS No.: 1437796-65-0
Chemical Name: Cyanine5 maleimide
Synonyms: CY5-IAL;CY5 MAL;Cyanine5 maleimide;3H-Indolium, 2-[3-[1-[6-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1-propen-1-yl]-3,3-dimethyl-5-sulfo-1-(3-sulfopropyl)-, inner salt (ACI)
CBNumber: CB13344988
Molecular Formula: C38H45ClN4O3
Formula Weight: 641.25
MOL File: 1437796-65-0.mol

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Cyanine5 maleimide Property

solubility: Soluble in DMSO, DMF, DCM
form: Solid
color: Brown to dark brown
Appearance: Dark blue solid
ex/em: 640/664 nm (PBS buffer)
ε(extinction coefficient): 250000 L⋅mol−1⋅cm−1
Φ(quantum yield): 0.2
InChIKey: IATQCUIJHBSCGA-UHFFFAOYSA-N
SMILES: C(N1C(C(C)(C)C2=CC=CC=C12)=CC=CC=CC1C(C2=CC=CC=C2[N+]=1C)(C)C)CCCCC(=O)NCCN1C(C=CC1=O)=O.[Cl-]

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22552
Product name: Cy5maleimide
Purity: 96%
Packaging: 1mg
Price: $100
Updated: 2021/12/16

BroadPharm

Product number: BP-22552
Product name: Cy5maleimide
Purity: 96%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

BroadPharm

Product number: BP-22552
Product name: Cy5maleimide
Purity: 96%
Packaging: 25mg
Price: $400
Updated: 2021/12/16

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Cyanine5 maleimide Chemical Properties,Usage,Production

Description

Cy5 maleimide is a mono-reactive dye containing maleimide group, which selectively couples with thiol groups (for example, with cysteines in peptides and proteins) to yield Cy5 (an analog of Cy5) labeled conjugates. Sulfo-Cy5 maleimide version is available for the labeling of antibodies and other sensitive proteins.

Chemical Properties

Appearance: Dark blue solid
ex/em: 640/664 nm (PBS buffer)
Extinction coefficient (ε): 250000 Lmol1cm1
Quantum yield (Φ): 0.2

Uses

Cy5 maleimide is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis[1]. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance[2].

References

[1] Maeda K, et al. Cy5 maleimide labelling for sensitive detection of free thiols in native protein extracts: identification of seed proteins targeted by barley thioredoxin h isoforms. Biochem J. 2004 Mar 1;378(Pt 2):497-507. DOI:10.1042/BJ20031634
[2] Ptaszek M. Rational design of fluorophores for in vivo applications. Prog Mol Biol Transl Sci. 2013;113:59-108. DOI:10.1016/B978-0-12-386932-6.00003-X
[3] Shindy, H. A. (2017). Fundamentals in the chemistry of cyanine dyes: A review. Dyes and Pigments, 145, 505–513. doi:10.1016/j.dyepig.2017.06.029

Abs/Em Maxima

646/662 nm

Fluoresene quantum yield

0.2

Extinction Coefficient

250000

CF260

0.03

CF280

0.04

Cyanine5 maleimide Preparation Products And Raw materials

Raw materials

Preparation Products

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Cyanine5 maleimide Suppliers

China 42 United States 2 Global 44

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View Lastest Price from Cyanine5 maleimide manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Cyanine5 maleimide 1437796-65-0
Price: US $0.00/mg
Min. Order: 25mg
Purity: >99.00%
Supply Ability: 25mg
Release date: 2024-03-29

1437796-65-0, Cyanine5 maleimideRelated Search:

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Cyanine5 maleimide

CY5 MAL

CY5-IAL

3H-Indolium, 2-[3-[1-[6-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1-propen-1-yl]-3,3-dimethyl-5-sulfo-1-(3-sulfopropyl)-, inner salt (ACI)

1437796-65-0