ChemicalBook > CAS DataBase List > AC 186
AC 186
- Product Name
- AC 186
- CAS No.
- 1421854-16-1
- Chemical Name
- AC 186
- Synonyms
- AC 186;AC186|||AC 186;AC-186, 10 mM in DMSO;4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol;Phenol, 4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]-
- CBNumber
- CB13356112
- Molecular Formula
- C18H17F3O
- Formula Weight
- 306.32
- MOL File
- 1421854-16-1.mol
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AC 186 Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- A solid
- color
- White to off-white
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Tocris
- Product number
- 5053
- Product name
- AC186
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $227
- Updated
- 2021/12/16
Tocris
- Product number
- 5053
- Product name
- AC186
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $925
- Updated
- 2021/12/16
Usbiological
- Product number
- 254507
- Product name
- AC 186
- Packaging
- 10mg
- Price
- $489
- Updated
- 2021/12/16
TRC
- Product number
- A305300
- Product name
- AC186
- Packaging
- 5mg
- Price
- $880
- Updated
- 2021/12/16
Ambeed
- Product number
- A958678
- Product name
- 4-(4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl)phenol
- Purity
- 99%
- Packaging
- 100mg
- Price
- $1103
- Updated
- 2021/12/16
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AC 186 Chemical Properties,Usage,Production
Uses
AC 186 is a selective estrogen receptor β (ERβ) agonist moderates cognitive deficits and amyloid-β levels in a mouse model of Alzheimer’s Disease. AC 186 also shows gender specific neuroprotection in a Parkinsons disease rat model.
in vivo
AC-186 (10 mg/kg; s.c.; once) exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease[1].
| Animal Model: | Male Sprague-Dawley rats ( 225-250 g) induced through bilateral 6-hydroxydopamine lesions of the substantia nigra[1]. |
| Dosage: | 10 mg/kg |
| Administration: | s.c.; once |
| Result: | Prevented motor, cognitive, and sensorimotor gating deficits and mitigated the loss of dopamine neurons in the substantia nigra, in males, but not in females. |
IC 50
ERβ: 6 nM (EC50); ERα: 5000 nM (EC50)
storage
Store at RT
AC 186 Preparation Products And Raw materials
Raw materials
Preparation Products
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