ChemicalBook > CAS DataBase List > PD-1/PD-L1 Inhibitor 3
PD-1/PD-L1 Inhibitor 3
- Product Name
- PD-1/PD-L1 Inhibitor 3
- CAS No.
- 1629654-95-0
- Chemical Name
- PD-1/PD-L1 Inhibitor 3
- Synonyms
- PD-1/PD-L1-IN 3;PD-1/PD-L1 Inhibitor 3;PD-1/PD-L1 Inhibitor 3 TFA;PD-1/PD-L1 Inhibitor 3 USP/EP/BP;Glycinamide, N-(2-mercaptoacetyl)-L-phenylalanyl-N-methyl-L-alanyl-L-asparaginyl-L-prolyl-L-histidyl-L-leucyl-N-methylglycyl-L-tryptophyl-L-seryl-L-tryptophyl-N-methyl-L-norleucyl-N-methyl-L-norleucyl-L-arginyl-L-cysteinyl-, cyclic (1→14)-thioether
- CBNumber
- CB13362748
- Molecular Formula
- C89H126N24O18S
- Formula Weight
- 1852.17
- MOL File
- 1629654-95-0.mol
More
Less
PD-1/PD-L1 Inhibitor 3 Property
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 13.14±0.70(Predicted)
More
Less
N-Bromosuccinimide Price
ApexBio Technology
- Product number
- B6191
- Product name
- PD-1/PD-L1Inhibitor3
- Packaging
- 5mg
- Price
- $1047
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC44154
- Product name
- PD-1/PD-L1-IN3
- Purity
- >98%
- Packaging
- 25mg
- Price
- $750
- Updated
- 2021/12/16
More
Less
PD-1/PD-L1 Inhibitor 3 Chemical Properties,Usage,Production
Uses
PD-1/PD-L1-IN 3, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC50s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 can be used for the research of various diseases, including cancer and infectious diseases[1].
Biological Activity
pd-1/pd-l1 inhibitor 3 is a pd-1/pd-l1 interaction inhibitor.the anti-pd-1 and anti-pd-l1 compounds have been found to show impressive antitumor effects in various malignancies, such as melanoma. the greatest clinical outcome in unselected patients has been observed in melanoma. the tumor expression of pd-l1 is suggested to be a suggestive, inadequate, and predictive of response to immune-checkpoint blockade.
in vitro
pd-1/pd-l1 inhibitor 3 has been identified to be a potent and selective small molecule inhibitor blocking the interaction of programmed cell death protein 1 (pd-1) with its ligand protein (pd-l1) and with cd80. pd-1/pd-l1 inhibitor 3 was also found to act as an immunomodulator. in addition, pd-1/pd-l1 inhibitor 3 was found to have highly efficacious binding to pd-l1 and promote the increased functional activities of t cells. therefore, pd-1/pd-l1 inhibitor 3 could be regarded as a promising therapeutic treatment of cancer and infectious diseases, such as hepatitis c [1].
target
| Target | Value |
| PD-1/PD-L1 interaction (Cell-free assay ) | 5.6 nM |
References
[1] miller michael matthew, et al. patent, pub. no.:wo/2014/151634
PD-1/PD-L1 Inhibitor 3 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
PD-1/PD-L1 Inhibitor 3 Suppliers
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 0571-89197072; 18668118770
- Fax
- 0571-89197072
- linda@peptide-china.com
- Country
- China
- ProdList
- 235
- Advantage
- 56
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8000
- Advantage
- 62
- Tel
- +86-17380623303
- Fax
- 028-62328193
- Caroline@youngshechem.com
- Country
- China
- ProdList
- 4802
- Advantage
- 58
- Tel
- 021-58111628 15800915896
- Fax
- QQ 3285589261
- sales@twochem.com
- Country
- China
- ProdList
- 1788
- Advantage
- 58
- Tel
- 0571-87213919
- Eric@peptidego.com
- Country
- China
- ProdList
- 7408
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4696
- Advantage
- 58
- Tel
- +8618531123677
- faithe@yan-xi.com
- Country
- China
- ProdList
- 5853
- Advantage
- 58
- Tel
- +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- +86-29-89586680 +86-15129568250
- 1026@dideu.com
- Country
- China
- ProdList
- 20284
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30229
- Advantage
- 58
- Tel
- 021-38015121 18438616290
- lanwu@univ-bio.com
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 13758194781 13173652190
- 522013271@qq.com
- Country
- China
- ProdList
- 2395
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 0510-85625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 14081
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 027-59101668 19945030958
- Fax
- 027-59101668
- 2881924765@qq.com
- Country
- China
- ProdList
- 7937
- Advantage
- 58
- Tel
- 15071299552
- Fax
- QQ:262933239
- 262933239@qq.com
- Country
- China
- ProdList
- 7047
- Advantage
- 58
- Tel
- 0371-65741762
- Fax
- QQ：2860768577
- sales@hasunny.com
- Country
- China
- ProdList
- 2380
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6753
- Advantage
- 58
- Tel
- 18168071971
- support@yuan-peptide.com
- Country
- China
- ProdList
- 2983
- Advantage
- 58
- Tel
- 17711399154
- 3211919385@qq.com
- Country
- China
- ProdList
- 1815
- Advantage
- 58
- Tel
- 0571-0571-88211921 19105816207
- sales4@gotopbio.com
- Country
- China
- ProdList
- 5144
- Advantage
- 58
- Tel
- 15387063101
- 2881924050@qq.com
- Country
- China
- ProdList
- 9958
- Advantage
- 58
- Tel
- 0571-87213919 17306812703
- 3007955328@qq.com
- Country
- China
- ProdList
- 6979
- Advantage
- 58
- Tel
- 0371-55013243 15324716602
- 2853979810@qq.com
- Country
- China
- ProdList
- 9898
- Advantage
- 58
- Tel
- 13770887460
- wenxi@jszkhy.com
- Country
- China
- ProdList
- 1354
- Advantage
- 58
- Tel
- 17751201929
- office@combiosz.com
- Country
- China
- ProdList
- 3000
- Advantage
- 58
- Tel
- 0571-88211951 13735575465
- sales1@gotopbio.com
- Country
- China
- ProdList
- 4880
- Advantage
- 58
- Tel
- 400-6206333 13167063860
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 48457
- Advantage
- 58
- Tel
- 17721492509; 17721492509
- 643638326@qq.com
- Country
- China
- ProdList
- 4970
- Advantage
- 58
- Tel
- 17316404525 17316404525
- 209533805@qq.com
- Country
- China
- ProdList
- 9765
- Advantage
- 58
- Tel
- 51288865780
- sales@biosynth.com
- Country
- China
- ProdList
- 6051
- Advantage
- 58
- Tel
- 400-668-6834
- info@selleck.cn
- Country
- China
- ProdList
- 6071
- Advantage
- 58
- Tel
- 17342063383
- sales@allpeptide.com
- Country
- China
- ProdList
- 5320
- Advantage
- 58
- Tel
- +86-18964595316
- Fax
- 027-65026759
- sales1@hybio.com.cn
- Country
- China
- ProdList
- 361
- Advantage
- 58
- Tel
- +86-755-89396905 +86-15013857715
- admin@nexconn.com
- Country
- China
- ProdList
- 10405
- Advantage
- 58
- Tel
- +8618327326525
- masar@topule.com
- Country
- China
- ProdList
- 8467
- Advantage
- 58
- Tel
- +86-17331933971
- Fax
- deasea125996@gmail.com
- deasea125996@gmail.com
- Country
- China
- ProdList
- 2472
- Advantage
- 58
- Tel
- +86-571-87711850
- market18@leapchem.com
- Country
- China
- ProdList
- 24727
- Advantage
- 58
- Tel
- 17765667235
- Country
- CHINA
- ProdList
- 129
- Advantage
- 58
- Tel
- 19928332050
- Country
- CHINA
- ProdList
- 161
- Advantage
- 58
- Tel
- 057186405477
- Country
- CHINA
- ProdList
- 184
- Advantage
- 58
- Tel
- 18818417021
- Country
- CHINA
- ProdList
- 127
- Advantage
- 58
- Tel
- 18028747627
- Country
- CHINA
- ProdList
- 191
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@biorbyt.com
- Country
- CHINA
- ProdList
- 6482
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6208
- Advantage
- 58
More
Less
View Lastest Price from PD-1/PD-L1 Inhibitor 3 manufacturers
Henan Bao Enluo International TradeCo.，LTD
- Product
- PD-1/PD-L1 Inhibitor 3 1629654-95-0
- Price
- US $45.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2023-05-18
Dideu Industries Group Limited
- Product
- PD-1/PD-L1 Inhibitor 3 1629654-95-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-17