ChemicalBook > CAS DataBase List > Val-Ala-PAB
Val-Ala-PAB
- Product Name
- Val-Ala-PAB
- CAS No.
- 1343476-44-7
- Chemical Name
- Val-Ala-PAB
- Synonyms
- Val-Ala-PAB-OH;(S)-2-Amino-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)-3-methylbutanamide;CS-2747;Val-Ala-PAB;H-Val-Ala-PAB;Val Ala PAB,ValAlaPAB;Val-Ala-PAB, 10 mM in DMSO;L-Alaninamide, L-valyl-N-[4-(hydroxymethyl)phenyl]-;(2S)-2-amino-N-[(1S)-1-{[4-(hydroxymethyl)phenyl]carbamoyl}ethyl]-3-methylbutanamide;(2S)-2-amino-N-[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]-3-methylbutanamide
- CBNumber
- CB13364146
- Molecular Formula
- C15H23N3O3
- Formula Weight
- 293.36
- MOL File
- 1343476-44-7.mol
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Val-Ala-PAB Property
- Melting point:
- 65-68°C
- Boiling point:
- 584.9±50.0 °C(Predicted)
- Density
- 1.191±0.06 g/cm3(Predicted)
- storage temp.
- -20°C, Inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 13.51±0.70(Predicted)
- form
- Solid
- color
- White to Off-White
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N-Bromosuccinimide Price
TRC
- Product number
- V091550
- Product name
- Val-Ala-PAB
- Packaging
- 1g
- Price
- $1210
- Updated
- 2021/12/16
TRC
- Product number
- V091550
- Product name
- Val-Ala-PAB
- Packaging
- 5g
- Price
- $4400
- Updated
- 2021/12/16
TRC
- Product number
- V091550
- Product name
- Val-Ala-PAB
- Packaging
- 25g
- Price
- $18700
- Updated
- 2021/12/16
Ambeed
- Product number
- A1492902
- Product name
- (S)-2-Amino-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)-3-methylbutanamide
- Purity
- 97%
- Packaging
- 50mg
- Price
- $163
- Updated
- 2021/12/16
Ambeed
- Product number
- A1492902
- Product name
- (S)-2-Amino-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)-3-methylbutanamide
- Purity
- 97%
- Packaging
- 100mg
- Price
- $249
- Updated
- 2021/12/16
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Val-Ala-PAB Chemical Properties,Usage,Production
Description
Val-Ala-PAB-OH is a cleavable ADC linker with a terminal hydroxyl group. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
Uses
Val-Ala-PAB is a building block in the synthesis of Tesirine (a.k.a. SG3249), a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload. Reagent in the preparation of pyrrolobenzodiazepine dimers and their antibody conjugates containing peptide linkers useful for treating proliferative including cancer.
Val-Ala-PAB Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Val-Ala-PAB manufacturers
Xian confluore Biological Technology Co., Ltd.
- Product
- Val-Ala-PAB-OH 1343476-44-7
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >95.00%
- Supply Ability
- 1g
- Release date
- 2024-03-29