Val-Ala-PAB

Product Name: Val-Ala-PAB
CAS No.: 1343476-44-7
Chemical Name: Val-Ala-PAB
Synonyms: Val-Ala-PAB-OH;(S)-2-Amino-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)-3-methylbutanamide;CS-2747;Val-Ala-PAB;H-Val-Ala-PAB;Val Ala PAB,ValAlaPAB;L-Alaninamide, L-valyl-N-[4-(hydroxymethyl)phenyl]-;(2S)-2-amino-N-[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]-3-methylbutanamide;(S)-2-Amino-N-[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-2-propyl]-3-methylbutanamide
CBNumber: CB13364146
Molecular Formula: C15H23N3O3
Formula Weight: 293.36
MOL File: 1343476-44-7.mol

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Val-Ala-PAB Property

Melting point:: 65-68°C
Boiling point:: 584.9±50.0 °C(Predicted)
Density: 1.191±0.06 g/cm3(Predicted)
storage temp.: -20°C, Inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 13.51±0.70(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: V091550
Product name: Val-Ala-PAB
Packaging: 1g
Price: $1210
Updated: 2021/12/16

TRC

Product number: V091550
Product name: Val-Ala-PAB
Packaging: 5g
Price: $4400
Updated: 2021/12/16

TRC

Product number: V091550
Product name: Val-Ala-PAB
Packaging: 25g
Price: $18700
Updated: 2021/12/16

Ambeed

Product number: A1492902
Product name: (S)-2-Amino-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)-3-methylbutanamide
Purity: 97%
Packaging: 50mg
Price: $163
Updated: 2021/12/16

Ambeed

Product number: A1492902
Product name: (S)-2-Amino-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)-3-methylbutanamide
Purity: 97%
Packaging: 100mg
Price: $249
Updated: 2021/12/16

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Val-Ala-PAB Chemical Properties,Usage,Production

Description

Val-Ala-PAB-OH is a cleavable ADC linker with a terminal hydroxyl group. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Uses

Val-Ala-PAB is a building block in the synthesis of Tesirine (a.k.a. SG3249), a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload. Reagent in the preparation of pyrrolobenzodiazepine dimers and their antibody conjugates containing peptide linkers useful for treating proliferative including cancer.

Val-Ala-PAB Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Val-Ala-PAB manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Val-Ala-PAB-OH 1343476-44-7
Price: US $0.00/g
Min. Order: 1g
Purity: >95.00%
Supply Ability: 1g
Release date: 2024-03-29

1343476-44-7, Val-Ala-PABRelated Search:

Val-Ala-PAB

CS-2747

(2S)-2-amino-N-[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]-3-methylbutanamide

L-Alaninamide, L-valyl-N-[4-(hydroxymethyl)phenyl]-

Val-Ala-PAB-OH

(S)-2-Amino-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)-3-methylbutanamide

Val Ala PAB,ValAlaPAB

H-Val-Ala-PAB

(S)-2-Amino-N-[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-2-propyl]-3-methylbutanamide

1343476-44-7

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